J 2012

Phosphoinositide 3-kinase inhibition enables retinoic acid-induced neurogenesis in monolayer culture of embryonic stem cells.

KOTASOVÁ, Hana, Iva VESELÁ, Jan KUČERA, Zbyněk HOUDEK, Jiřina PROCHÁZKOVÁ et. al.

Basic information

Original name

Phosphoinositide 3-kinase inhibition enables retinoic acid-induced neurogenesis in monolayer culture of embryonic stem cells.

Authors

KOTASOVÁ, Hana (203 Czech Republic, guarantor, belonging to the institution), Iva VESELÁ (203 Czech Republic, belonging to the institution), Jan KUČERA (203 Czech Republic, belonging to the institution), Zbyněk HOUDEK (203 Czech Republic), Jiřina PROCHÁZKOVÁ (203 Czech Republic, belonging to the institution), Milena KRÁLÍČKOVÁ (203 Czech Republic) and Jiří PACHERNÍK (203 Czech Republic, belonging to the institution)

Edition

J Cell Biochem, Wiley-Liss, Inc. 2012, 0730-2312

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30105 Physiology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.062

RIV identification code

RIV/00216224:14310/12:00057219

Organization unit

Faculty of Science

DOI

UT WoS

000298843200022

Keywords in English

Embryonic stem cell;retionic acid;neurogenesis;differentiation

Tags

Tags

International impact, Reviewed
Změněno: 22/4/2013 13:55, Ing. Andrea Mikešková

Abstract

V originále

Retinoic acid is able to induce the differentiation of embryonic stem cells into neuronal lineages. The mechanism of this effect is unknown but it has been evidenced to be dependent on the formation of floating spheroids called embryoid bodies. Results presented here show that the inhibition of phosphoinositide 3-kinase signaling predetermines mouse embryonic stem cells to retinoic acid induced neurogenesis in monolayer culture with no need of embryoid bodies formation.

Links

GA301/08/0717, research and development project
Name: Regulace diferenciace ES buněk prostřednictvím receptoru gp130
Investor: Czech Science Foundation, Gp130 receptor-mediated differentiation of ES cells
GD204/09/H058, research and development project
Name: Mezibuněčná signalizace ve vývoji organismu a vzniku onemocnění
Investor: Czech Science Foundation, Intercellular signalling in development and disease
MSM0021622430, plan (intention)
Name: Funkční a molekulární charakteristiky nádorových a normálních kmenových buněk - identifikace cílů pro nová terapeutika a terapeutické strategie
Investor: Ministry of Education, Youth and Sports of the CR, Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies