PROCHÁZKOVÁ, Jiřina, Lukáš KUBALA, Hana KOTASOVÁ, Iva GUDERNOVÁ, Zuzana ŠRÁMKOVÁ, Michaela PEKAROVÁ, Balazs SARKADI and Jiří PACHERNÍK. ABC transporters affect the detection of intracellular oxidants by fluorescent probes. Free Radical Res. 2011, vol. 45, No 7, p. 779-787. ISSN 1071-5762. Available from: https://dx.doi.org/10.3109/10715762.2011.579120.
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Basic information
Original name ABC transporters affect the detection of intracellular oxidants by fluorescent probes.
Authors PROCHÁZKOVÁ, Jiřina (203 Czech Republic, guarantor, belonging to the institution), Lukáš KUBALA (203 Czech Republic, belonging to the institution), Hana KOTASOVÁ (203 Czech Republic, belonging to the institution), Iva GUDERNOVÁ (203 Czech Republic, belonging to the institution), Zuzana ŠRÁMKOVÁ (703 Slovakia, belonging to the institution), Michaela PEKAROVÁ (703 Slovakia, belonging to the institution), Balazs SARKADI (348 Hungary) and Jiří PACHERNÍK (203 Czech Republic, belonging to the institution).
Edition Free Radical Res. 2011, 1071-5762.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30105 Physiology
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.878
RIV identification code RIV/00216224:14310/11:00050241
Organization unit Faculty of Science
Doi http://dx.doi.org/10.3109/10715762.2011.579120
UT WoS 000291222100004
Keywords in English Fluorescence; redox status; mitochondria; reactive oxygen species (ROS)
Tags AKR, rivok
Changed by Changed by: Ing. Andrea Mikešková, učo 137293. Changed: 20/4/2012 11:41.
Abstract
Intracellular production of reactive oxygen species (ROS) plays an important role in the control of cell physiology. For the assessment of intracellular ROS production, a plethora of fluorescent probes is commonly used. Interestingly, chemical structures of these probes imply they could be substrates of plasma membrane efflux pumps, called ABC transporters. This study tested whether the determination of intracellular ROS production and mitochondrial membrane potential by selected fluorescent probes is modulated by the expression and activity of ABC transporters.
Links
GA301/08/0717, research and development projectName: Regulace diferenciace ES buněk prostřednictvím receptoru gp130
Investor: Czech Science Foundation, Gp130 receptor-mediated differentiation of ES cells
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