KRUPKOVÁ, Olga, Jindřiška HAMMEROVÁ, Tereza VACLOVÁ and Stjepan ULDRIJAN. P38 MAPK - a Potential Target for Metastatic Melanoma Therapy? In European Multidisciplinary Cancer Congress on Integrating Basic and Translational Science, Surgery, Radiotherapy, Medical oncology, Advocacy and Care. 2011. ISSN 0959-8049.
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Basic information
Original name P38 MAPK - a Potential Target for Metastatic Melanoma Therapy?
Authors KRUPKOVÁ, Olga (203 Czech Republic, guarantor, belonging to the institution), Jindřiška HAMMEROVÁ (203 Czech Republic, belonging to the institution), Tereza VACLOVÁ (203 Czech Republic) and Stjepan ULDRIJAN (203 Czech Republic, belonging to the institution).
Edition European Multidisciplinary Cancer Congress on Integrating Basic and Translational Science, Surgery, Radiotherapy, Medical oncology, Advocacy and Care, 2011.
Other information
Original language English
Type of outcome Conference abstract
Field of Study 30000 3. Medical and Health Sciences
Country of publisher Sweden
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 5.536
RIV identification code RIV/00216224:14110/11:00056996
Organization unit Faculty of Medicine
ISSN 0959-8049
UT WoS 000295752800366
Keywords in English melanoma p38 MAPK targeted therapy autophagy
Changed by Changed by: Mgr. Olga Krupková, učo 175588. Changed: 14/12/2011 17:00.
Abstract
We have shown previously, that a small molecular inhibitor of p38 MAPK SB202190 (SB) selectively induces autophagy in MM cell lines, but not in other cell types we tested. We have demonstrated that SB-induced autophagy promotes cell survival and combining SB with autophagy inhibitors can lead to a significant decrease of MM cell viability.
Links
NS10236, research and development projectName: Terapeutický potenciál inhibice vybraných signálních drah v buňkách maligního melanomu
Investor: Ministry of Health of the CR
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