J 2011

Methylation of plant telomeric DNA: what do the results say?

MAJEROVÁ, Eva, Miloslava FOJTOVÁ, Terezie MANDÁKOVÁ and Jiří FAJKUS

Basic information

Original name

Methylation of plant telomeric DNA: what do the results say?

Authors

MAJEROVÁ, Eva (203 Czech Republic, belonging to the institution), Miloslava FOJTOVÁ (203 Czech Republic, belonging to the institution), Terezie MANDÁKOVÁ (203 Czech Republic, belonging to the institution) and Jiří FAJKUS (203 Czech Republic, guarantor, belonging to the institution)

Edition

Plant Molecular Biology, Springer, 2011, 0167-4412

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

Genetics and molecular biology

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 4.150

RIV identification code

RIV/00216224:14740/11:00049500

Organization unit

Central European Institute of Technology

DOI

UT WoS

000299051300002

Keywords in English

Nicotiana tabacum; Cell culture Telomere; Hypomethylating agents; Zebularine; DNA methylation

Tags

Tags

International impact, Reviewed
Změněno: 14/6/2016 10:59, Mgr. Eva Špillingová

Abstract

V originále

Recently, we reported (Majerova et al. 2011) that hypomethylating drugs efficiently decrease methylation of telomeric DNA and activate telomerase without affecting telomere lengths in tobacco. The key issue of the Letter to Editor written by Vaquero-Sedas and Vega-Palas (2011) is, whether our results demonstrating methylation and druginduced hypomethylation of tobacco telomeric DNA repeats do correspond to the status of terminal telomeric sequences, or rather to internal telomeric sequences (ITSs) which might exist in tobacco genome as it is the case in Arabidopsis thaliana, the model organism which Vaquero- Sedas and Vega-Palas have been working with. They are referring to their recent article (Vaquero-Sedas et al. 2010) in which they conclude that ITSs in A. thaliana are heterochromatic, while telomeres are euchromatic. We are pleased that our paper has initiated this debate and take the opportunity to go through the key points of the Letter of Vaquero-Sedas and Vega-Palas

Links

GA204/08/1530, research and development project
Name: Objasnění úlohy proteinu HMGB1 v udržování genomové stability
Investor: Czech Science Foundation, Understanding of HMGB1 protein involvement in maintaining genome stability
IAA500040801, research and development project
Name: Telomery a telomerázy: posun od molekulárně-biologického ke strukturně-biologickému přístupu.
Investor: Academy of Sciences of the Czech Republic, Telomeres and telomerase: transition from molecular to structural biology approach
LC06035, research and development project
Name: Centrum biofyzikální chemie, bioelektrochemie a bioanalýzy. Nové nástroje pro genomiku, proteomiku a biomedicínu.
Investor: Ministry of Education, Youth and Sports of the CR, Centre of Biophysical Chemistry, Bioelectrochemistry and Bioanalysis. New Tools for Genomics, Proteomics and Biomedicine
MSM0021622415, plan (intention)
Name: Molekulární podstata buněčných a tkáňových regulací
Investor: Ministry of Education, Youth and Sports of the CR, Molecular basis of cell and tissue regulations