In Silico Engineering of Proteins that Recognize Small Molecules

MISHRA, Sushil Kumar, Gabriel DEMO, Jaroslav KOČA and Michaela WIMMEROVÁ. In Silico Engineering of Proteins that Recognize Small Molecules. In Prof. Pravin Kaumaya. Protein Engineering. Neuveden: InTech - Open Access Publisher, 2012, p. 307-344. ISBN 978-953-51-0037-9.

Basic information

• Original name: In Silico Engineering of Proteins that Recognize Small Molecules
• Name in Czech: In Silico inzenyrstvi proteinu rozpoznavajici male molekuly
• Authors: MISHRA, Sushil Kumar (356 India, belonging to the institution), Gabriel DEMO (703 Slovakia, belonging to the institution), Jaroslav KOČA (203 Czech Republic, belonging to the institution) and Michaela WIMMEROVÁ (203 Czech Republic, guarantor, belonging to the institution).
• Edition: Neuveden, Protein Engineering, p. 307-344, 38 pp. 2012.
• Publisher: InTech - Open Access Publisher

Other information

• Original language: English
• Type of outcome: Chapter(s) of a specialized book
• Field of Study: 10600 1.6 Biological sciences
• Country of publisher: Croatia
• Confidentiality degree: is not subject to a state or trade secret
• Publication form: printed version "print"
• WWW: URL URL
• RIV identification code: RIV/00216224:14740/12:00057223
• Organization unit: Central European Institute of Technology
• ISBN: 978-953-51-0037-9
• Keywords (in Czech): in silico protein struktura mutageneze docking specifita
• Keywords in English: in silico protein structure mutagenesis docking specificity
• Tags: ok, rivok
• Tags: International impact, Reviewed

Abstract

Protein engineering is a rapidly evolving discipline, with much research currently focused on understanding the catalysis, specificity, stability, and folding of proteins, structure-function relationships and protein design principles. Engineered proteins are now successfully being used in biotechnology and in therapeutic settings. Advances in technology and genetic and chemical techniques have enabled a competitive edge in developing improved protein and peptide based therapeutics with reduced immunogenicity, improved safety and greater effectiveness.

Abstract (in Czech)

Proteinove inzenyrstvi je rapidne se rozvijejici disciplinou, zamerujici se v soucasnosti k pochopeni katalyzy, specificity, stability a usporadani proteinu, strukturne-funkcnim vztahum a proteinovemu designu pouzivanemu v biotechnologiich a v terapeuticke lecbe. Pokroky v technologii a genetickych a chemickych technikach umoznili rozsireni moznosti ve vyvoji leciv zalozenych na vylepsenych proteinech a peptidech se zmensenou imunogenicitou, lepsi bezpecnosti a vetsi efektivitou.

Links

• ED1.1.00/02.0068, research and development project: Name: CEITEC - central european institute of technology
• GAP207/10/0321, research and development project: Name: Enzymy metabolismu mannosidů v přípravě N-acetyl-mannosaminových struktur

Investor: Czech Science Foundation

• GA303/09/1168, research and development project: Name: Lektiny z lidských patogenů - struktura, funkce, inženýrství

Investor: Czech Science Foundation, Lectins from human pathogens - structure, function, engineering

• GD301/09/H004, research and development project: Name: Molekulární a strukturní biologie vybraných cytostatik. Od mechanistických studií k chemoterapii rakoviny

Investor: Czech Science Foundation

• ME08008, research and development project: Name: Návrh antibakteriálních a antivirových léků na bázi cukrů a glykomimetik

Investor: Ministry of Education, Youth and Sports of the CR, Design of Carbohydrates and Glycomimetics as Antibacterial and Antiviral Drugs, Research and Development Programme KONTAKT (ME)

• MSM0021622413, plan (intention): Name: Proteiny v metabolismu a při interakci organismů s prostředím

Investor: Ministry of Education, Youth and Sports of the CR, Proteins in metabolism and interaction of organisms with the environment