In Silico Engineering of Proteins that Recognize Small Molecules

MISHRA, Sushil Kumar, Gabriel DEMO, Jaroslav KOČA and Michaela WIMMEROVÁ. In Silico Engineering of Proteins that Recognize Small Molecules. In Prof. Pravin Kaumaya. Protein Engineering. Neuveden: InTech - Open Access Publisher, 2012, p. 307-344. ISBN 978-953-51-0037-9.

Basic information

Original name

In Silico Engineering of Proteins that Recognize Small Molecules

Name in Czech

In Silico inzenyrstvi proteinu rozpoznavajici male molekuly

Authors

MISHRA, Sushil Kumar (356 India, belonging to the institution), Gabriel DEMO (703 Slovakia, belonging to the institution), Jaroslav KOČA (203 Czech Republic, belonging to the institution) and Michaela WIMMEROVÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Neuveden, Protein Engineering, p. 307-344, 38 pp. 2012

Publisher

InTech - Open Access Publisher

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Other information

Language

English

Type of outcome

Kapitola resp. kapitoly v odborné knize

Field of Study

10600 1.6 Biological sciences

Country of publisher

Croatia

Confidentiality degree

není předmětem státního či obchodního tajemství

Publication form

printed version "print"

References:

URL URL

RIV identification code

RIV/00216224:14740/12:00057223

Organization unit

Central European Institute of Technology

ISBN

978-953-51-0037-9

Keywords (in Czech)

in silico protein struktura mutageneze docking specifita

Keywords in English

in silico protein structure mutagenesis docking specificity

Tags

ok, rivok

Tags

International impact, Reviewed

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Abstract

V originále

Protein engineering is a rapidly evolving discipline, with much research currently focused on understanding the catalysis, specificity, stability, and folding of proteins, structure-function relationships and protein design principles. Engineered proteins are now successfully being used in biotechnology and in therapeutic settings. Advances in technology and genetic and chemical techniques have enabled a competitive edge in developing improved protein and peptide based therapeutics with reduced immunogenicity, improved safety and greater effectiveness.

In Czech

Proteinove inzenyrstvi je rapidne se rozvijejici disciplinou, zamerujici se v soucasnosti k pochopeni katalyzy, specificity, stability a usporadani proteinu, strukturne-funkcnim vztahum a proteinovemu designu pouzivanemu v biotechnologiich a v terapeuticke lecbe. Pokroky v technologii a genetickych a chemickych technikach umoznili rozsireni moznosti ve vyvoji leciv zalozenych na vylepsenych proteinech a peptidech se zmensenou imunogenicitou, lepsi bezpecnosti a vetsi efektivitou.

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Links

ED1.1.00/02.0068, research and development project	Name: CEITEC - central european institute of technology
GAP207/10/0321, research and development project	Name: Enzymy metabolismu mannosidů v přípravě N-acetyl-mannosaminových struktur Investor: Czech Science Foundation
GA303/09/1168, research and development project	Name: Lektiny z lidských patogenů - struktura, funkce, inženýrství Investor: Czech Science Foundation, Lectins from human pathogens - structure, function, engineering
GD301/09/H004, research and development project	Name: Molekulární a strukturní biologie vybraných cytostatik. Od mechanistických studií k chemoterapii rakoviny Investor: Czech Science Foundation
ME08008, research and development project	Name: Návrh antibakteriálních a antivirových léků na bázi cukrů a glykomimetik Investor: Ministry of Education, Youth and Sports of the CR, Design of Carbohydrates and Glycomimetics as Antibacterial and Antiviral Drugs, Research and Development Programme KONTAKT (ME)
MSM0021622413, plan (intention)	Name: Proteiny v metabolismu a při interakci organismů s prostředím Investor: Ministry of Education, Youth and Sports of the CR, Proteins in metabolism and interaction of organisms with the environment