J 2011

Prognostic significance of morphological assessment of plasma cells in multiple myeloma.

AL-SAHMANI, Mohamed Abdo Saleh, Irena TRNAVSKÁ, Sabina ŠEVČÍKOVÁ, M. ANTOSOVA, L. ANTOSOVA et. al.

Basic information

Original name

Prognostic significance of morphological assessment of plasma cells in multiple myeloma.

Authors

AL-SAHMANI, Mohamed Abdo Saleh (887 Yemen, belonging to the institution), Irena TRNAVSKÁ (203 Czech Republic, belonging to the institution), Sabina ŠEVČÍKOVÁ (203 Czech Republic, belonging to the institution), M. ANTOSOVA (203 Czech Republic), L. ANTOSOVA (203 Czech Republic), J. KISSOVA (203 Czech Republic), Zdeněk ADAM (203 Czech Republic, belonging to the institution), Luděk POUR (203 Czech Republic, belonging to the institution), Pavel NĚMEC (703 Slovakia, belonging to the institution), Henrieta GREŠLIKOVÁ (703 Slovakia, belonging to the institution), Marta KREJČÍ (203 Czech Republic, belonging to the institution), Lenka ZAHRADOVÁ (203 Czech Republic, belonging to the institution), Alena BULIKOVÁ (203 Czech Republic, belonging to the institution), Miroslav PENKA (203 Czech Republic, belonging to the institution) and Roman HÁJEK (203 Czech Republic, guarantor, belonging to the institution)

Edition

Neoplasma, Bratislava, Slovenská republika, Slovak Academic Press, Ltd, 2011, 0028-2685

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

Slovakia

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.440

RIV identification code

RIV/00216224:14110/11:00050354

Organization unit

Faculty of Medicine

DOI

UT WoS

000295392600013

Keywords in English

multiple myeloma; morphology; plasma cells; cytogenetics; prognostic significance; nucleus

Tags

International impact
Změněno: 20/4/2012 15:12, Mgr. Michal Petr

Abstract

V originále

Multiple myeloma (MM) is a hematological malignancy caused by clonal proliferation of malignant plasma cells (PC). The aim of the work is to determine prognostic significance of morphological subtypes of PC in relation to overall treatment response, long-term survival and other conventional prognostic parameters. One hundred and thirty-nine newly diagnosed MM patients who underwent autologous transplantation in clinical trials conducted in one center were included. Our work brings valuable prognostic information and correlation with other prognostic factors as well as total treatment response and survival in MM patients who underwent autologous transplantation.

Links

GAP304/10/1395, research and development project
Name: Analýza klonálních progenitorů plazmatických buněk u monoklonálních gamapatií
Investor: Czech Science Foundation
LC06027, research and development project
Name: Univerzitní výzkumné centrum - Česká myelomová skupina (Acronym: LC MGUS)
Investor: Ministry of Education, Youth and Sports of the CR, University Research Centre - Czech Myeloma Group
MSM0021622434, plan (intention)
Name: Od klasických prognostických markerů ke klinicky aplikovatelným farmakogenomickým a farmakoproteomickým projektům u mnohočetného myelomu a monoklonálních gamapatií
Investor: Ministry of Education, Youth and Sports of the CR, From classic prognostic markers to clinical applications in selected pharmacogenomic and pharmacoproteomic projects in multiple myeloma and monoclonal gammapathies
NS10406, research and development project
Name: Vytvoření prognostického panelu u pacientů s monoklonální gamapatií nejasného významu s cílem zabránění transformace v maligní onemocnění.
Investor: Ministry of Health of the CR