| HAO, J., S. KURODA, K. OHYA, Sonia BARTÁKOVÁ, H. AOKI and Shohei KASUGAI. Enhanced osteoblast and osteoclast responses to a thin film sputtered hydroxyapatite coating. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE. Japan, 2011, vol. 22, No 6, p. 1489-1499. ISSN 0957-4530. Available from: https://dx.doi.org/10.1007/s10856-011-4329-0. |
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@article{965969,
author = {Hao, J. and Kuroda, S. and Ohya, K. and Bartáková, Sonia and Aoki, H. and Kasugai, Shohei},
article_location = {Japan},
article_number = {6},
doi = {http://dx.doi.org/10.1007/s10856-011-4329-0},
keywords = {implant; coating; hydroxyapatite},
language = {eng},
issn = {0957-4530},
journal = {JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE},
title = {Enhanced osteoblast and osteoclast responses to a thin film sputtered hydroxyapatite coating},
volume = {22},
year = {2011}
}
TY - JOUR
ID - 965969
AU - Hao, J. - Kuroda, S. - Ohya, K. - Bartáková, Sonia - Aoki, H. - Kasugai, Shohei
PY - 2011
TI - Enhanced osteoblast and osteoclast responses to a thin film sputtered hydroxyapatite coating
JF - JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
VL - 22
IS - 6
SP - 1489-1499
EP - 1489-1499
SN - 09574530
KW - implant
KW - coating
KW - hydroxyapatite
N2 - A sputtering technique followed by a low temperature hydrothermal treatment has been demonstrated to produce a dense-and-bioactive hydroxyapatite thin film coating. The purpose of the present study was to investigate osteoblast and osteoclast responses to the hydroxyapatite coated plates and titanium plates with similar roughness. Rat bone marrow stromal cells were cultured on these plates to induce osteoblasts. The cells showed a significantly enhanced proliferation on the hydroxyapatite surface, accompanied by increase of osteoblastic phenotypes. The co-cultured osteoclasts exhibited the significantly different cell number and morphology between the hydroxyapatite and the titanium surfaces. A series of osteoclast marker genes were more stimulated on the hydroxyapatite and thirty two percent of the hydroxyapatite surface area could be resorbed by osteoclasts. The thin film sputtered hydroxyapatite could provide a favorable surface for both osteoblast and osteoclast formation and their function, indicating its good osteoconductivity and biodegradability.
ER -
HAO, J., S. KURODA, K. OHYA, Sonia BARTÁKOVÁ, H. AOKI and Shohei KASUGAI. Enhanced osteoblast and osteoclast responses to a thin film sputtered hydroxyapatite coating. \textit{JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE}. Japan, 2011, vol.~22, No~6, p.~1489-1499. ISSN~0957-4530. Available from: https://dx.doi.org/10.1007/s10856-011-4329-0.
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