CRHÁK KHAITOVÁ, Lucie, Miloslava FOJTOVÁ, Kateřina KŘÍŽOVÁ, Jana LUNEROVÁ, Jaroslav FULNEČEK, Anna DEPICKER and Aleš KOVAŘÍK. Paramutation of tobacco transgenes by small RNA-mediated transcriptional gene silencing. Epigenetics. Austin: Landes Bioscience, 2011, vol. 6, No 5, p. 650-660. ISSN 1559-2294. Available from: https://dx.doi.org/10.4161/epi.6.5.15764.
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Basic information
Original name Paramutation of tobacco transgenes by small RNA-mediated transcriptional gene silencing
Authors CRHÁK KHAITOVÁ, Lucie (203 Czech Republic, guarantor), Miloslava FOJTOVÁ (203 Czech Republic, belonging to the institution), Kateřina KŘÍŽOVÁ (203 Czech Republic), Jana LUNEROVÁ (203 Czech Republic), Jaroslav FULNEČEK (203 Czech Republic), Anna DEPICKER (56 Belgium) and Aleš KOVAŘÍK (203 Czech Republic).
Edition Epigenetics, Austin, Landes Bioscience, 2011, 1559-2294.
Other information
Original language English
Type of outcome Article in a journal
Field of Study Genetics and molecular biology
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 4.318
RIV identification code RIV/00216224:14740/11:00054886
Organization unit Central European Institute of Technology
Doi http://dx.doi.org/10.4161/epi.6.5.15764
UT WoS 000290203600015
Keywords in English transcriptional gene silencing; transgene epialleles; DNA methylation; small RNA
Tags ok, rivok
Tags International impact, Reviewed
Changed by Changed by: Olga Křížová, učo 56639. Changed: 13/4/2012 00:44.
Abstract
It has been well established that trans-acting small RNAs guide promoter methylation leading to its inactivation and gene silencing at the transcriptional level (TGS).These features contrast with a non-methylated single copy transgenic locus that required several generations of contact with RNA silencing molecules to become imprinted in a stable epiallele.
Links
MSM0021622415, plan (intention)Name: Molekulární podstata buněčných a tkáňových regulací
Investor: Ministry of Education, Youth and Sports of the CR, Molecular basis of cell and tissue regulations
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