| PERNICOVÁ, Zuzana, Eva SLÁBÁKOVÁ, Gvantsa KHARAISHVILI, Jan BOUCHAL, Milan KRÁL, Zuzana KUNICKÁ, Miroslav MACHALA, Alois KOZUBÍK and Karel SOUČEK. Androgen Depletion Induces Senescence in Prostate Cancer Cells through Down-regulation of Skp2. Neoplasia. Neoplasia Press, 2011, vol. 13, No 6, p. 526-536. ISSN 1522-8002. Available from: https://dx.doi.org/10.1593/neo.11182. |
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@article{966014,
author = {Pernicová, Zuzana and Slábáková, Eva and Kharaishvili, Gvantsa and Bouchal, Jan and Král, Milan and Kunická, Zuzana and Machala, Miroslav and Kozubík, Alois and Souček, Karel},
article_number = {6},
doi = {http://dx.doi.org/10.1593/neo.11182},
keywords = {CELLULAR SENESCENCE; IN-VIVO; DEPRIVATION THERAPY; SECRETORY PHENOTYPE; EPITHELIAL-CELLS; TUMORIGENESIS; FIBROBLASTS; EXPRESSION; GROWTH; PROLIFERATION},
language = {eng},
issn = {1522-8002},
journal = {Neoplasia},
title = {Androgen Depletion Induces Senescence in Prostate Cancer Cells through Down-regulation of Skp2},
url = {http://www.neoplasia.com/pdf/manuscript/v13i06/neo11182.pdf},
volume = {13},
year = {2011}
}
TY - JOUR
ID - 966014
AU - Pernicová, Zuzana - Slábáková, Eva - Kharaishvili, Gvantsa - Bouchal, Jan - Král, Milan - Kunická, Zuzana - Machala, Miroslav - Kozubík, Alois - Souček, Karel
PY - 2011
TI - Androgen Depletion Induces Senescence in Prostate Cancer Cells through Down-regulation of Skp2
JF - Neoplasia
VL - 13
IS - 6
SP - 526-536
EP - 526-536
PB - Neoplasia Press
SN - 15228002
KW - CELLULAR SENESCENCE
KW - IN-VIVO
KW - DEPRIVATION THERAPY
KW - SECRETORY PHENOTYPE
KW - EPITHELIAL-CELLS
KW - TUMORIGENESIS
KW - FIBROBLASTS
KW - EXPRESSION
KW - GROWTH
KW - PROLIFERATION
UR - http://www.neoplasia.com/pdf/manuscript/v13i06/neo11182.pdf
L2 - http://www.neoplasia.com/pdf/manuscript/v13i06/neo11182.pdf
N2 - Although the induction of senescence in cancer cells is a potent mechanism of tumor suppression, senescent cells remain metabolically active and may secrete a broad spectrum of factors that promote tumorigenicity in neighboring malignant cells.We propose that ADT may contribute to the development of androgen-independent prostate cancer through modulation of the tissue microenvironment by senescent cells.
ER -
PERNICOVÁ, Zuzana, Eva SLÁBÁKOVÁ, Gvantsa KHARAISHVILI, Jan BOUCHAL, Milan KRÁL, Zuzana KUNICKÁ, Miroslav MACHALA, Alois KOZUBÍK and Karel SOUČEK. Androgen Depletion Induces Senescence in Prostate Cancer Cells through Down-regulation of Skp2. \textit{Neoplasia}. Neoplasia Press, 2011, vol.~13, No~6, p.~526-536. ISSN~1522-8002. Available from: https://dx.doi.org/10.1593/neo.11182.
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