Androgen Depletion Induces Senescence in Prostate Cancer Cells
through Down-regulation of Skp2

J 2011

Androgen Depletion Induces Senescence in Prostate Cancer Cells through Down-regulation of Skp2

PERNICOVÁ, Zuzana, Eva SLÁBÁKOVÁ, Gvantsa KHARAISHVILI, Jan BOUCHAL, Milan KRÁL et. al.

Basic information

Original name

Androgen Depletion Induces Senescence in Prostate Cancer Cells through Down-regulation of Skp2

Authors

PERNICOVÁ, Zuzana (203 Czech Republic, guarantor), Eva SLÁBÁKOVÁ (203 Czech Republic), Gvantsa KHARAISHVILI (203 Czech Republic), Jan BOUCHAL (203 Czech Republic), Milan KRÁL (203 Czech Republic), Zuzana KUNICKÁ (203 Czech Republic, belonging to the institution), Miroslav MACHALA (203 Czech Republic), Alois KOZUBÍK (203 Czech Republic, belonging to the institution) and Karel SOUČEK (203 Czech Republic)

Edition

Neoplasia, Neoplasia Press, 2011, 1522-8002

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

Genetics and molecular biology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.946

RIV identification code

RIV/00216224:14740/11:00054887

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1593/neo.11182

UT WoS

000295448800004

Keywords in English

CELLULAR SENESCENCE; IN-VIVO; DEPRIVATION THERAPY; SECRETORY PHENOTYPE; EPITHELIAL-CELLS; TUMORIGENESIS; FIBROBLASTS; EXPRESSION; GROWTH; PROLIFERATION

Abstract

V originále

Although the induction of senescence in cancer cells is a potent mechanism of tumor suppression, senescent cells remain metabolically active and may secrete a broad spectrum of factors that promote tumorigenicity in neighboring malignant cells.We propose that ADT may contribute to the development of androgen-independent prostate cancer through modulation of the tissue microenvironment by senescent cells.

Links

MSM0021622415, plan (intention)

Name: Molekulární podstata buněčných a tkáňových regulací

Investor: Ministry of Education, Youth and Sports of the CR, Molecular basis of cell and tissue regulations

MSM0021622430, plan (intention)

Name: Funkční a molekulární charakteristiky nádorových a normálních kmenových buněk - identifikace cílů pro nová terapeutika a terapeutické strategie

Investor: Ministry of Education, Youth and Sports of the CR, Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies

Citovat

PERNICOVÁ, Zuzana, Eva SLÁBÁKOVÁ, Gvantsa KHARAISHVILI, Jan BOUCHAL, Milan KRÁL, Zuzana KUNICKÁ, Miroslav MACHALA, Alois KOZUBÍK and Karel SOUČEK. Androgen Depletion Induces Senescence in Prostate Cancer Cells through Down-regulation of Skp2. Neoplasia. Neoplasia Press, 2011, vol. 13, No 6, p. 526-536. ISSN 1522-8002. Available from: https://dx.doi.org/10.1593/neo.11182.

@article{966014,
   author = {Pernicová, Zuzana and Slábáková, Eva and Kharaishvili, Gvantsa and Bouchal, Jan and Král, Milan and Kunická, Zuzana and Machala, Miroslav and Kozubík, Alois and Souček, Karel},
   article_number = {6},
   doi = {http://dx.doi.org/10.1593/neo.11182},
   keywords = {CELLULAR SENESCENCE; IN-VIVO; DEPRIVATION THERAPY; SECRETORY PHENOTYPE; EPITHELIAL-CELLS; TUMORIGENESIS; FIBROBLASTS; EXPRESSION; GROWTH; PROLIFERATION},
   language = {eng},
   issn = {1522-8002},
   journal = {Neoplasia},
   title = {Androgen Depletion Induces Senescence in Prostate Cancer Cells through Down-regulation of Skp2},
   url = {http://www.neoplasia.com/pdf/manuscript/v13i06/neo11182.pdf},
   volume = {13},
   year = {2011}
}

TY  - JOUR
ID  - 966014
AU  - Pernicová, Zuzana - Slábáková, Eva - Kharaishvili, Gvantsa - Bouchal, Jan - Král, Milan - Kunická, Zuzana - Machala, Miroslav - Kozubík, Alois - Souček, Karel
PY  - 2011
TI  - Androgen Depletion Induces Senescence in Prostate Cancer Cells through Down-regulation of Skp2
JF  - Neoplasia
VL  - 13
IS  - 6
SP  - 526-536
EP  - 526-536
PB  - Neoplasia Press
SN  - 15228002
KW  - CELLULAR SENESCENCE
KW  - IN-VIVO
KW  - DEPRIVATION THERAPY
KW  - SECRETORY PHENOTYPE
KW  - EPITHELIAL-CELLS
KW  - TUMORIGENESIS
KW  - FIBROBLASTS
KW  - EXPRESSION
KW  - GROWTH
KW  - PROLIFERATION
UR  - http://www.neoplasia.com/pdf/manuscript/v13i06/neo11182.pdf
L2  - http://www.neoplasia.com/pdf/manuscript/v13i06/neo11182.pdf
N2  - Although the induction of senescence in cancer cells is a potent mechanism of tumor suppression, senescent cells remain metabolically active and may secrete a broad spectrum of factors that promote tumorigenicity in neighboring malignant cells.We propose that ADT may contribute to the development of androgen-independent prostate cancer through modulation of the tissue microenvironment by senescent cells.
ER  -

PERNICOVÁ, Zuzana, Eva SLÁBÁKOVÁ, Gvantsa KHARAISHVILI, Jan BOUCHAL, Milan KRÁL, Zuzana KUNICKÁ, Miroslav MACHALA, Alois KOZUBÍK and Karel SOUČEK. Androgen Depletion Induces Senescence in Prostate Cancer Cells through Down-regulation of Skp2. \textit{Neoplasia}. Neoplasia Press, 2011, vol.~13, No~6, p.~526-536. ISSN~1522-8002. Available from: https://dx.doi.org/10.1593/neo.11182.

Detailed Information on Publication Record