Detailed Information on Publication Record
2011
Role of Everlasting Triplet Expansions in Protein Evolution
KOREN, Zohar and Eduard TRIFONOVBasic information
Original name
Role of Everlasting Triplet Expansions in Protein Evolution
Authors
KOREN, Zohar (376 Israel) and Eduard TRIFONOV (376 Israel, guarantor, belonging to the institution)
Edition
Journal of molecular evolution. New York, Springer, 2011, 0022-2844
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
Genetics and molecular biology
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 2.274
RIV identification code
RIV/00216224:14740/11:00054893
Organization unit
Central European Institute of Technology
UT WoS
000288808400011
Keywords in English
Codon usage; Evolutionary play-ground; Fast adaptation; First exons; Genome inflation; Homopeptides; Selfish DNA; Tandem repeats; Triplet code; Triplet expansion disorders
Tags
International impact, Reviewed
Změněno: 25/3/2012 07:59, Olga Křížová
Abstract
V originále
Analysis of occurrence of simple amino acid repeats in large ensemble of prokaryotic and eukaryotic sequences reveals that nearly all amino acids found in the repeats belong to those which have in their codon repertoires aggressively expanding triplets, all of three known pathologically expanding classes GCU (GCU, CUG, UGC, AGC, GCA, CAG), GCC (GCC, CCG, CGC, GGC, GCG, CGG), and AAG (AAG, AGA, GAA, CTT, TTC, TCT).The spontaneous expansions continued to occur all the way during evolution, leaving their footprints in the protein-coding sequences as still visible simple amino acid repeats, as preferred triplets encoding the repeats, and as preferred codons in the codon usage tables.
Links
| MSM0021622415, plan (intention) |
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