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@article{966039, author = {Koren, Zohar and Trifonov, Eduard}, article_location = {New York}, article_number = {2}, doi = {http://dx.doi.org/10.1007/s00239-010-9425-0}, keywords = {Codon usage; Evolutionary play-ground; Fast adaptation; First exons; Genome inflation; Homopeptides; Selfish DNA; Tandem repeats; Triplet code; Triplet expansion disorders}, language = {eng}, issn = {0022-2844}, journal = {Journal of molecular evolution.}, title = {Role of Everlasting Triplet Expansions in Protein Evolution}, volume = {72}, year = {2011} }
TY - JOUR ID - 966039 AU - Koren, Zohar - Trifonov, Eduard PY - 2011 TI - Role of Everlasting Triplet Expansions in Protein Evolution JF - Journal of molecular evolution. VL - 72 IS - 2 SP - 232-239 EP - 232-239 PB - Springer SN - 00222844 KW - Codon usage KW - Evolutionary play-ground KW - Fast adaptation KW - First exons KW - Genome inflation KW - Homopeptides KW - Selfish DNA KW - Tandem repeats KW - Triplet code KW - Triplet expansion disorders N2 - Analysis of occurrence of simple amino acid repeats in large ensemble of prokaryotic and eukaryotic sequences reveals that nearly all amino acids found in the repeats belong to those which have in their codon repertoires aggressively expanding triplets, all of three known pathologically expanding classes GCU (GCU, CUG, UGC, AGC, GCA, CAG), GCC (GCC, CCG, CGC, GGC, GCG, CGG), and AAG (AAG, AGA, GAA, CTT, TTC, TCT).The spontaneous expansions continued to occur all the way during evolution, leaving their footprints in the protein-coding sequences as still visible simple amino acid repeats, as preferred triplets encoding the repeats, and as preferred codons in the codon usage tables. ER -
KOREN, Zohar and Eduard TRIFONOV. Role of Everlasting Triplet Expansions in Protein Evolution. \textit{Journal of molecular evolution.}. New York: Springer, 2011, vol.~72, No~2, p.~232-239. ISSN~0022-2844. Available from: https://dx.doi.org/10.1007/s00239-010-9425-0.
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