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@article{966039,
author = {Koren, Zohar and Trifonov, Eduard},
article_location = {New York},
article_number = {2},
doi = {http://dx.doi.org/10.1007/s00239-010-9425-0},
keywords = {Codon usage; Evolutionary play-ground; Fast adaptation; First exons; Genome inflation; Homopeptides; Selfish DNA; Tandem repeats; Triplet code; Triplet expansion disorders},
language = {eng},
issn = {0022-2844},
journal = {Journal of molecular evolution.},
title = {Role of Everlasting Triplet Expansions in Protein Evolution},
volume = {72},
year = {2011}
}
TY - JOUR
ID - 966039
AU - Koren, Zohar - Trifonov, Eduard
PY - 2011
TI - Role of Everlasting Triplet Expansions in Protein Evolution
JF - Journal of molecular evolution.
VL - 72
IS - 2
SP - 232-239
EP - 232-239
PB - Springer
SN - 00222844
KW - Codon usage
KW - Evolutionary play-ground
KW - Fast adaptation
KW - First exons
KW - Genome inflation
KW - Homopeptides
KW - Selfish DNA
KW - Tandem repeats
KW - Triplet code
KW - Triplet expansion disorders
N2 - Analysis of occurrence of simple amino acid repeats in large ensemble of prokaryotic and eukaryotic sequences reveals that nearly all amino acids found in the repeats belong to those which have in their codon repertoires aggressively expanding triplets, all of three known pathologically expanding classes GCU (GCU, CUG, UGC, AGC, GCA, CAG), GCC (GCC, CCG, CGC, GGC, GCG, CGG), and AAG (AAG, AGA, GAA, CTT, TTC, TCT).The spontaneous expansions continued to occur all the way during evolution, leaving their footprints in the protein-coding sequences as still visible simple amino acid repeats, as preferred triplets encoding the repeats, and as preferred codons in the codon usage tables.
ER -
KOREN, Zohar and Eduard TRIFONOV. Role of Everlasting Triplet Expansions in Protein Evolution. \textit{Journal of molecular evolution.}. New York: Springer, 2011, vol.~72, No~2, p.~232-239. ISSN~0022-2844. Available from: https://dx.doi.org/10.1007/s00239-010-9425-0.
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