Další formáty:
BibTeX
LaTeX
RIS
@article{966062, author = {Hapala, Jan and Trifonov, Eduard}, article_number = {1}, doi = {http://dx.doi.org/10.1016/j.gene.2011.08.022}, keywords = {AG-ends of introns; Gene splicing; GT-ends of introns; Nucleosome mapping; Protection of splice junctions; Rotational positioning}, language = {eng}, issn = {0378-1119}, journal = {Gene}, title = {High resolution positioning of intron ends on the nucleosomes}, volume = {489}, year = {2011} }
TY - JOUR ID - 966062 AU - Hapala, Jan - Trifonov, Eduard PY - 2011 TI - High resolution positioning of intron ends on the nucleosomes JF - Gene VL - 489 IS - 1 SP - 6-10 EP - 6-10 PB - Elsevier SN - 03781119 KW - AG-ends of introns KW - Gene splicing KW - GT-ends of introns KW - Nucleosome mapping KW - Protection of splice junctions KW - Rotational positioning N2 - High resolution sequence-directed nucleosome mapping is applied to 36,000 sequences containing splice junctions, from five different species.Moreover, the orientation of guanine residues at the GT- and AG-ends of introns within the nucleosomes is such that the guanines are positioned nearest to the surface of histone octamers, 3 and 4 bases upstream from the local DNA pseudo-dyads passing through minor grooves oriented outwards. Since the guanine residues are the most vulnerable to spontaneous damage within the cell (primarily, depurination and oxidation) such positioning of the splice junctions minimizes the damage that is caused by free radicals and highly reactive metabolites. ER -
HAPALA, Jan a Eduard TRIFONOV. High resolution positioning of intron ends on the nucleosomes. \textit{Gene}. Elsevier, 2011, roč.~489, č.~1, s.~6-10. ISSN~0378-1119. Dostupné z: https://dx.doi.org/10.1016/j.gene.2011.08.022.
|