Detailed Information on Publication Record
2011
High resolution positioning of intron ends on the nucleosomes
HAPALA, Jan and Eduard TRIFONOVBasic information
Original name
High resolution positioning of intron ends on the nucleosomes
Authors
HAPALA, Jan (203 Czech Republic, belonging to the institution) and Eduard TRIFONOV (376 Israel, guarantor, belonging to the institution)
Edition
Gene, Elsevier, 2011, 0378-1119
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
Genetics and molecular biology
Country of publisher
Netherlands
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 2.341
RIV identification code
RIV/00216224:14740/11:00054899
Organization unit
Central European Institute of Technology
UT WoS
000296415900002
Keywords in English
AG-ends of introns; Gene splicing; GT-ends of introns; Nucleosome mapping; Protection of splice junctions; Rotational positioning
Tags
International impact, Reviewed
Změněno: 13/4/2012 08:52, Olga Křížová
Abstract
V originále
High resolution sequence-directed nucleosome mapping is applied to 36,000 sequences containing splice junctions, from five different species.Moreover, the orientation of guanine residues at the GT- and AG-ends of introns within the nucleosomes is such that the guanines are positioned nearest to the surface of histone octamers, 3 and 4 bases upstream from the local DNA pseudo-dyads passing through minor grooves oriented outwards. Since the guanine residues are the most vulnerable to spontaneous damage within the cell (primarily, depurination and oxidation) such positioning of the splice junctions minimizes the damage that is caused by free radicals and highly reactive metabolites.
Links
| MSM0021622415, plan (intention) |
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| SIGA 792, interní kód MU |
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