J 2012

The logarithm of the triglyceride/HDL-cholesterol ratio is related to the history of cardiovascular disease in patients with familial hypercholesterolemia

SOŠKA, Vladimír, Jiří JARKOVSKÝ, Barbora RAVČUKOVÁ, Lukáš TICHÝ, Lenka FAJKUSOVÁ et. al.

Basic information

Original name

The logarithm of the triglyceride/HDL-cholesterol ratio is related to the history of cardiovascular disease in patients with familial hypercholesterolemia

Authors

SOŠKA, Vladimír (203 Czech Republic, guarantor, belonging to the institution), Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution), Barbora RAVČUKOVÁ (203 Czech Republic), Lukáš TICHÝ (203 Czech Republic), Lenka FAJKUSOVÁ (203 Czech Republic, belonging to the institution) and Tomáš FREIBERGER (203 Czech Republic, belonging to the institution)

Edition

Clinical Biochemistry, 2012, 0009-9120

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10600 1.6 Biological sciences

Country of publisher

Canada

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.450

RIV identification code

RIV/00216224:14110/12:00059220

Organization unit

Faculty of Medicine

UT WoS

000299364800020

Keywords in English

Cardiovascular risk; Triglycerides/HDL-cholesterol ratio; Atherogenic index of plasma; Lipoprotein particle size

Tags

International impact, Reviewed
Změněno: 22/4/2013 13:44, Soňa Böhmová

Abstract

V originále

The aim of this study was to determine whether the atherogenic index of plasma (AIP=log [triglycerides/HDL-cholesterol]) differs in heterozygous familial hypercholesterolemia (FH) patients with and without a history of cardiovascular disease (CVD). Design and methods: A total of 555 FH patients with known mutations in the LDL receptor or the apolipoprotein B gene, of whom 53 had a history of CVD (CVD+ group), were retrospectively analyzed. Results: Compared to patients without CVD (CVD- group), CVD+ patients showed significantly higher fasting LDL-cholesterol, triglycerides and AIP as well as lower HDL-cholesterol. After both adjustment for age and diabetes and using analysis based on age and sex matched groups, only the increase in triglycerides and AIP in the CVD+ vs. the CVD- group remained significant. Conclusion: The results of the present study indicate that AIP, which reflects the presence of atherogenic small LDL and small HDL particles, may be connected to the risk of CVD in FH patients.

Links

CZ.1.05/1.1.00/02.0068, interní kód MU
Name: CEITEC - středoevropský technologický institut (Acronym: CEITEC)
Investor: Ministry of Education, Youth and Sports of the CR, CEITEC - Central European Institute of Technology, 1.1 European Centres of Excellence
ED1.1.00/02.0068, research and development project
Name: CEITEC - central european institute of technology
MSM0021622415, plan (intention)
Name: Molekulární podstata buněčných a tkáňových regulací
Investor: Ministry of Education, Youth and Sports of the CR, Molecular basis of cell and tissue regulations
2B08060, research and development project
Name: Vývoj diagnostiky a léčby závažných onemocnění srdce a cév pomocí genomických a epigenomických přístupů (Acronym: EPICARD)
Investor: Ministry of Education, Youth and Sports of the CR, Development of diagnostics and treatment of serious heart and vascular diseases using genomic and proteomic approaches