Clinical significance of the plasminogen activator system in
relation to grade of tumor and treatment response in colorectal
carcinoma patients

J 2011

Clinical significance of the plasminogen activator system in relation to grade of tumor and treatment response in colorectal carcinoma patients

HALÁMKOVÁ, Jana, Igor KISS, Zdeněk PAVLOVSKÝ, Jiří TOMÁŠEK, Jiří JARKOVSKÝ et. al.

Basic information

Original name

Clinical significance of the plasminogen activator system in relation to grade of tumor and treatment response in colorectal carcinoma patients

Authors

HALÁMKOVÁ, Jana (203 Czech Republic, guarantor, belonging to the institution), Igor KISS (203 Czech Republic, belonging to the institution), Zdeněk PAVLOVSKÝ (203 Czech Republic, belonging to the institution), Jiří TOMÁŠEK (203 Czech Republic, belonging to the institution), Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution), Zbyněk ČECH (203 Czech Republic, belonging to the institution), Štěpán TUČEK (203 Czech Republic, belonging to the institution), L. HANÁKOVÁ (203 Czech Republic), Mojmír MOULIS (203 Czech Republic, belonging to the institution), J. ZAVŘELOVÁ (203 Czech Republic), M. MAN (203 Czech Republic), Petr BENDA (203 Czech Republic, belonging to the institution), Oldřich ROBEK (203 Czech Republic, belonging to the institution), Zdeněk KALA (203 Czech Republic, belonging to the institution) and Miroslav PENKA (203 Czech Republic, belonging to the institution)

Edition

Neoplasma, 2011, 0028-2685

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

Slovakia

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.440

RIV identification code

RIV/00216224:14110/11:00055096

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.4149/neo_2011_05_377

UT WoS

000295309700003

Keywords in English

colorectal cancer; plasminogen activator system; grade; treatment response

Abstract

V originále

Urokinase (uPA) plays an essential role in the activation of plasminogen to plasmin, and together with its receptor (uPAR), tissue activator (tPA) and urokinase inhibitors (PAI 1, PAI 2, PAI 3 and protease nexin) forms the plasminogen activator system (PAS), a component of metastatic cascade importantly contributing to the invasive growth and angiogenesis of malignant tumours. In our project we examined the expression of uPA, uPAR, PAI 1 and PAI 2 in tumor tissue and we also studied the plasma levels of PAI 1 before and after the initiation of therapy in patients with colorectal carcinoma in relationship to grade of tumor and the treatment response. In our prospective evaluation we included 80 patients treated for adenocarcinoma of the colon and rectum. Analysis of collected data revealed statistically significant evidence of a relationship between the level of PAI 1 in plasma before treatment and grade of the tumor, which increases with tumor grade (p=0.025). We demonstrated that there exists a statistically significant relationship between the expression of PAI 2 and uPAR (p=0.031) and grade of tumor. We also confirmed a statistically significant relationship between soluble levels of PAI 1 before treatment and therapeutic response (p=0.021). In our group of patients the expression of uPA, uPAR, PAI 1 and 2 in tumor tissue in relation to response to treatment was also assessed. Our results suggest that the greater expression of these parameters in tumor tissue is linked to a worse response to therapy. In conclusion, PAS factors help as a prognostic indicators and could also act as a predictive factor in colorectal carcinoma.

Citovat

HALÁMKOVÁ, Jana, Igor KISS, Zdeněk PAVLOVSKÝ, Jiří TOMÁŠEK, Jiří JARKOVSKÝ, Zbyněk ČECH, Štěpán TUČEK, L. HANÁKOVÁ, Mojmír MOULIS, J. ZAVŘELOVÁ, M. MAN, Petr BENDA, Oldřich ROBEK, Zdeněk KALA and Miroslav PENKA. Clinical significance of the plasminogen activator system in relation to grade of tumor and treatment response in colorectal carcinoma patients. Neoplasma. 2011, vol. 58, No 5, p. 377-385. ISSN 0028-2685. Available from: https://dx.doi.org/10.4149/neo_2011_05_377.

@article{967811,
   author = {Halámková, Jana and Kiss, Igor and Pavlovský, Zdeněk and Tomášek, Jiří and Jarkovský, Jiří and Čech, Zbyněk and Tuček, Štěpán and Hanáková, L. and Moulis, Mojmír and Zavřelová, J. and Man, M. and Benda, Petr and Robek, Oldřich and Kala, Zdeněk and Penka, Miroslav},
   article_number = {5},
   doi = {http://dx.doi.org/10.4149/neo_2011_05_377},
   keywords = {colorectal cancer; plasminogen activator system; grade; treatment response},
   language = {eng},
   issn = {0028-2685},
   journal = {Neoplasma},
   title = {Clinical significance of the plasminogen activator system in relation to grade of tumor and treatment response in colorectal carcinoma patients},
   volume = {58},
   year = {2011}
}

TY  - JOUR
ID  - 967811
AU  - Halámková, Jana - Kiss, Igor - Pavlovský, Zdeněk - Tomášek, Jiří - Jarkovský, Jiří - Čech, Zbyněk - Tuček, Štěpán - Hanáková, L. - Moulis, Mojmír - Zavřelová, J. - Man, M. - Benda, Petr - Robek, Oldřich - Kala, Zdeněk - Penka, Miroslav
PY  - 2011
TI  - Clinical significance of the plasminogen activator system in relation to grade of tumor and treatment response in colorectal carcinoma patients
JF  - Neoplasma
VL  - 58
IS  - 5
SP  - 377-385
EP  - 377-385
SN  - 00282685
KW  - colorectal cancer
KW  - plasminogen activator system
KW  - grade
KW  - treatment response
N2  - Urokinase (uPA) plays an essential role in the activation of plasminogen to plasmin, and together with its receptor (uPAR), tissue activator (tPA) and urokinase inhibitors (PAI 1, PAI 2, PAI 3 and protease nexin) forms the plasminogen activator system (PAS), a component of metastatic cascade importantly contributing to the invasive growth and angiogenesis of malignant tumours. In our project we examined the expression of uPA, uPAR, PAI 1 and PAI 2 in tumor tissue and we also studied the plasma levels of PAI 1 before and after the initiation of therapy in patients with colorectal carcinoma in relationship to grade of tumor and the treatment response. In our prospective evaluation we included 80 patients treated for adenocarcinoma of the colon and rectum. Analysis of collected data revealed statistically significant evidence of a relationship between the level of PAI 1 in plasma before treatment and grade of the tumor, which increases with tumor grade (p=0.025). We demonstrated that there exists a statistically significant relationship between the expression of PAI 2 and uPAR (p=0.031) and grade of tumor. We also confirmed a statistically significant relationship between soluble levels of PAI 1 before treatment and therapeutic response (p=0.021). In our group of patients the expression of uPA, uPAR, PAI 1 and 2 in tumor tissue in relation to response to treatment was also assessed. Our results suggest that the greater expression of these parameters in tumor tissue is linked to a worse response to therapy. In conclusion, PAS factors help as a prognostic indicators and could also act as a predictive factor in colorectal carcinoma.
ER  -

HALÁMKOVÁ, Jana, Igor KISS, Zdeněk PAVLOVSKÝ, Jiří TOMÁŠEK, Jiří JARKOVSKÝ, Zbyněk ČECH, Štěpán TUČEK, L. HANÁKOVÁ, Mojmír MOULIS, J. ZAVŘELOVÁ, M. MAN, Petr BENDA, Oldřich ROBEK, Zdeněk KALA and Miroslav PENKA. Clinical significance of the plasminogen activator system in relation to grade of tumor and treatment response in colorectal carcinoma patients. \textit{Neoplasma}. 2011, vol.~58, No~5, p.~377-385. ISSN~0028-2685. Available from: https://dx.doi.org/10.4149/neo\_{}2011\_{}05\_{}377.

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