Soluble BAFF Levels Inversely Correlate with Peripheral B Cell
Numbers and the Expression of BAFF Receptors

J 2012

Soluble BAFF Levels Inversely Correlate with Peripheral B Cell Numbers and the Expression of BAFF Receptors

KREUZALER, Matthias, Melanie RAUCH, Ulrich SALZER, Jennifer BIRMELIN, Marta RIZZI et. al.

Basic information

Original name

Soluble BAFF Levels Inversely Correlate with Peripheral B Cell Numbers and the Expression of BAFF Receptors

Authors

KREUZALER, Matthias (756 Switzerland, guarantor), Melanie RAUCH (756 Switzerland), Ulrich SALZER (276 Germany), Jennifer BIRMELIN (826 United Kingdom of Great Britain and Northern Ireland), Marta RIZZI (276 Germany), Bodo GRIMBACHER (826 United Kingdom of Great Britain and Northern Ireland), Alessandro PLEBANI (380 Italy), Vassilios LOUGARIS (380 Italy), Isabella QUINTI (380 Italy), Vojtěch THON (203 Czech Republic, belonging to the institution), Jiří LITZMAN (203 Czech Republic, belonging to the institution), Michael SCHLESIER (276 Germany), Klaus WARNATZ (276 Germany), Jens THIEL (276 Germany), Antonius G. ROLINK (756 Switzerland) and Hermann EIBEL (276 Germany)

Edition

The Journal of Immunology, 2012, 0022-1767

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30300 3.3 Health sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.520

RIV identification code

RIV/00216224:14110/12:00059246

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.4049/jimmunol.1102321

UT WoS

000298628400057

Keywords in English

chronic lymphocytic leukemia; Creactive protein; common variable immunodeficiency; primary antibody deficiency; systemic lupus erythematosus

Abstract

V originále

The TNF family member protein BAFF/BLyS is essential for B cell survival and plays an important role in regulating class switch recombination as well as in the selection of autoreactive B cells. In humans, increased concentrations of soluble BAFF are found in different pathological conditions, which may be as diverse as autoimmune diseases, B cell malignancies, and primary Ab deficiencies (PAD). Because the mechanisms that regulate BAFF levels are not well understood, we newly developed a set of mAbs against human BAFF to study the parameters that determine the concentrations of soluble BAFF in circulation. Patients with PAD, including severe functional B cell defects such as BTK, BAFF-R, or TACI deficiency, were found to have higher BAFF levels than asplenic individuals, patients after anti-CD20 B cell depletion, chronic lymphocytic leukemia patients, or healthy donors. In a comparable manner, mice constitutively expressing human BAFF were found to have higher concentrations of BAFF in the absence than in the presence of B cells. Therefore, our data strongly suggest that BAFF steady-state concentrations mainly depend on the number of B cells as well as on the expression of BAFF-binding receptors. Because most patients with PAD have high levels of circulating BAFF, the increase in BAFF concentrations cannot compensate defects in B cell development and function.

Links

7E08062, research and development project

Name: Pathophysiology and Natural Course of Primary Antibody Deficiency (PAD) Syndromes

Investor: Ministry of Education, Youth and Sports of the CR, Pathophysiology and Natural Course of Primary Antibody Deficiency (PAD) Syndromes

Citovat

KREUZALER, Matthias, Melanie RAUCH, Ulrich SALZER, Jennifer BIRMELIN, Marta RIZZI, Bodo GRIMBACHER, Alessandro PLEBANI, Vassilios LOUGARIS, Isabella QUINTI, Vojtěch THON, Jiří LITZMAN, Michael SCHLESIER, Klaus WARNATZ, Jens THIEL, Antonius G. ROLINK and Hermann EIBEL. Soluble BAFF Levels Inversely Correlate with Peripheral B Cell Numbers and the Expression of BAFF Receptors. The Journal of Immunology. 2012, vol. 188, No 1, p. 497-503. ISSN 0022-1767. Available from: https://dx.doi.org/10.4049/jimmunol.1102321.

@article{968038,
   author = {Kreuzaler, Matthias and Rauch, Melanie and Salzer, Ulrich and Birmelin, Jennifer and Rizzi, Marta and Grimbacher, Bodo and Plebani, Alessandro and Lougaris, Vassilios and Quinti, Isabella and Thon, Vojtěch and Litzman, Jiří and Schlesier, Michael and Warnatz, Klaus and Thiel, Jens and Rolink, Antonius G. and Eibel, Hermann},
   article_number = {1},
   doi = {http://dx.doi.org/10.4049/jimmunol.1102321},
   keywords = {chronic lymphocytic leukemia; Creactive protein; common variable immunodeficiency; primary antibody deficiency; systemic lupus erythematosus},
   language = {eng},
   issn = {0022-1767},
   journal = {The Journal of Immunology},
   title = {Soluble BAFF Levels Inversely Correlate with Peripheral B Cell Numbers and the Expression of BAFF Receptors},
   url = {http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1102321},
   volume = {188},
   year = {2012}
}

TY  - JOUR
ID  - 968038
AU  - Kreuzaler, Matthias - Rauch, Melanie - Salzer, Ulrich - Birmelin, Jennifer - Rizzi, Marta - Grimbacher, Bodo - Plebani, Alessandro - Lougaris, Vassilios - Quinti, Isabella - Thon, Vojtěch - Litzman, Jiří - Schlesier, Michael - Warnatz, Klaus - Thiel, Jens - Rolink, Antonius G. - Eibel, Hermann
PY  - 2012
TI  - Soluble BAFF Levels Inversely Correlate with Peripheral B Cell Numbers and the Expression of BAFF Receptors
JF  - The Journal of Immunology
VL  - 188
IS  - 1
SP  - 497-503
EP  - 497-503
SN  - 00221767
KW  - chronic lymphocytic leukemia
KW  - Creactive protein
KW  - common variable immunodeficiency
KW  - primary antibody deficiency
KW  - systemic lupus erythematosus
UR  - http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1102321
N2  - The TNF family member protein BAFF/BLyS is essential for B cell survival and plays an important role in regulating class switch recombination as well as in the selection of autoreactive B cells. In humans, increased concentrations of soluble BAFF are found in different pathological conditions, which may be as diverse as autoimmune diseases, B cell malignancies, and primary Ab deficiencies (PAD). Because the mechanisms that regulate BAFF levels are not well understood, we newly developed a set of mAbs against human BAFF to study the parameters that determine the concentrations of soluble BAFF in circulation. Patients with PAD, including severe functional B cell defects such as BTK, BAFF-R, or TACI deficiency, were found to have higher BAFF levels than asplenic individuals, patients after anti-CD20 B cell depletion, chronic lymphocytic leukemia patients, or healthy donors. In a comparable manner, mice constitutively expressing human BAFF were found to have higher concentrations of BAFF in the absence than in the presence of B cells. Therefore, our data strongly suggest that BAFF steady-state concentrations mainly depend on the number of B cells as well as on the expression of BAFF-binding receptors. Because most patients with PAD have high levels of circulating BAFF, the increase in BAFF concentrations cannot compensate defects in B cell development and function.
ER  -

KREUZALER, Matthias, Melanie RAUCH, Ulrich SALZER, Jennifer BIRMELIN, Marta RIZZI, Bodo GRIMBACHER, Alessandro PLEBANI, Vassilios LOUGARIS, Isabella QUINTI, Vojtěch THON, Jiří LITZMAN, Michael SCHLESIER, Klaus WARNATZ, Jens THIEL, Antonius G. ROLINK and Hermann EIBEL. Soluble BAFF Levels Inversely Correlate with Peripheral B Cell Numbers and the Expression of BAFF Receptors. \textit{The Journal of Immunology}. 2012, vol.~188, No~1, p.~497-503. ISSN~0022-1767. Available from: https://dx.doi.org/10.4049/jimmunol.1102321.

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