ŽUREK, Jiří and Michal FEDORA. Dynamics of Glial Fibrillary Acidic Protein During Traumatic Brain Injury in Children. The Journal of Trauma: Injury, Infection and Critical Care. Lippincott Williams & Wilkins, 2011, vol. 71, No 4, p. 854-859. ISSN 0022-5282. Available from: https://dx.doi.org/10.1097/TA.0b013e3182140c8c. |
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@article{969074, author = {Žurek, Jiří and Fedora, Michal}, article_number = {4}, doi = {http://dx.doi.org/10.1097/TA.0b013e3182140c8c}, keywords = {Glial fibrillary acidic protein; brain injury; outcome; children}, language = {eng}, issn = {0022-5282}, journal = {The Journal of Trauma: Injury, Infection and Critical Care}, title = {Dynamics of Glial Fibrillary Acidic Protein During Traumatic Brain Injury in Children}, volume = {71}, year = {2011} }
TY - JOUR ID - 969074 AU - Žurek, Jiří - Fedora, Michal PY - 2011 TI - Dynamics of Glial Fibrillary Acidic Protein During Traumatic Brain Injury in Children JF - The Journal of Trauma: Injury, Infection and Critical Care VL - 71 IS - 4 SP - 854-859 EP - 854-859 PB - Lippincott Williams & Wilkins SN - 00225282 KW - Glial fibrillary acidic protein KW - brain injury KW - outcome KW - children N2 - Backgrounds: Glial fibrillary acidic protein (GFAP) is a monomeric intermediate filament protein found in the astroglial cytoskeleton and is not found outside the central nervous system. It is a brain-specific protein that is released after traumatic brain injury (TBI). Methods: This prospective study enrolled 59 children who had TBI, as verified by computed tomography. Daily GFAP measurement began at admission (< 12 hours after trauma) and continued for 6 days. Blood samples were analyzed for GFAP by enzyme-linked immunosorbent assay. Outcome was assessed using the Glasgow Outcome Scale (GOS) at 6 months after injury. Results: The median serum levels of GFAP at admission were 7.47 ng/mL in patients who died, compared with 0.12 ng/mL in patients who survived (p = 0.002). GFAP levels were significantly higher in patients who had a poor outcome 6 months after injury than in those who were alive or had good outcome (p < 0.001). The area under the receiver operating characteristic curve for GFAP was 0.833 for day 0 and 0.884 for day 2. Conclusions: These results suggest that determination of serum levels of GFAP may add to the clinical assessment of the primary damage and prediction of outcome after severe TBI. ER -
ŽUREK, Jiří and Michal FEDORA. Dynamics of Glial Fibrillary Acidic Protein During Traumatic Brain Injury in Children. \textit{The Journal of Trauma: Injury, Infection and Critical Care}. Lippincott Williams \&{} Wilkins, 2011, vol.~71, No~4, p.~854-859. ISSN~0022-5282. Available from: https://dx.doi.org/10.1097/TA.0b013e3182140c8c.
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