ŽUREK, Jiří and Michal FEDORA. Dynamics of Glial Fibrillary Acidic Protein During Traumatic Brain Injury in Children. The Journal of Trauma: Injury, Infection and Critical Care. Lippincott Williams & Wilkins, 2011, vol. 71, No 4, p. 854-859. ISSN 0022-5282. Available from: https://dx.doi.org/10.1097/TA.0b013e3182140c8c.
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Basic information
Original name Dynamics of Glial Fibrillary Acidic Protein During Traumatic Brain Injury in Children
Authors ŽUREK, Jiří (203 Czech Republic, guarantor, belonging to the institution) and Michal FEDORA (203 Czech Republic, belonging to the institution).
Edition The Journal of Trauma: Injury, Infection and Critical Care, Lippincott Williams & Wilkins, 2011, 0022-5282.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30200 3.2 Clinical medicine
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.478
RIV identification code RIV/00216224:14110/11:00055261
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1097/TA.0b013e3182140c8c
UT WoS 000295925700020
Keywords in English Glial fibrillary acidic protein; brain injury; outcome; children
Tags International impact
Changed by Changed by: Mgr. Michal Petr, učo 65024. Changed: 2/2/2012 09:45.
Abstract
Backgrounds: Glial fibrillary acidic protein (GFAP) is a monomeric intermediate filament protein found in the astroglial cytoskeleton and is not found outside the central nervous system. It is a brain-specific protein that is released after traumatic brain injury (TBI). Methods: This prospective study enrolled 59 children who had TBI, as verified by computed tomography. Daily GFAP measurement began at admission (< 12 hours after trauma) and continued for 6 days. Blood samples were analyzed for GFAP by enzyme-linked immunosorbent assay. Outcome was assessed using the Glasgow Outcome Scale (GOS) at 6 months after injury. Results: The median serum levels of GFAP at admission were 7.47 ng/mL in patients who died, compared with 0.12 ng/mL in patients who survived (p = 0.002). GFAP levels were significantly higher in patients who had a poor outcome 6 months after injury than in those who were alive or had good outcome (p < 0.001). The area under the receiver operating characteristic curve for GFAP was 0.833 for day 0 and 0.884 for day 2. Conclusions: These results suggest that determination of serum levels of GFAP may add to the clinical assessment of the primary damage and prediction of outcome after severe TBI.
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