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@inbook{969117,
author = {Muthu Raja, Karthick Raja and Hájek, Roman},
address = {Rijeka},
booktitle = {Multiple Myeloma - An Overview},
editor = {Ajay Gupta},
keywords = {Multiple Myeloma; Tumor Cells; Immune System; Regulatory Cells},
howpublished = {tištěná verze "print"},
language = {eng},
location = {Rijeka},
isbn = {978-953-307-768-0},
pages = {33-60},
publisher = {InTech},
title = {Regulatory Cells and Multiple Myeloma},
url = {http://www.intechopen.com/articles/show/title/regulatory-cells-and-multiple-myeloma},
year = {2012}
}
TY - CHAP
ID - 969117
AU - Muthu Raja, Karthick Raja - Hájek, Roman
PY - 2012
TI - Regulatory Cells and Multiple Myeloma
VL - Oncology
PB - InTech
CY - Rijeka
SN - 9789533077680
KW - Multiple Myeloma
KW - Tumor Cells
KW - Immune System
KW - Regulatory Cells
UR - http://www.intechopen.com/articles/show/title/regulatory-cells-and-multiple-myeloma
N2 - Large evidence is available in hematological malignancies and solid tumors for elevated level of various regulatory and suppressor cells which impede anti-tumor responses. Therefore, targeting the regulatory cells could be a useful strategy to enhance the anti-tumor immunity. Approaches of depletion or inhibition of regulatory cells showed countable benefits in pre-clinical and clinical studies of some cancers including renal cell carcinoma, metastatic melanoma and colorectal carcinoma. Targeting regulatory T cells in a non-specific approach might cause detrimental autoimmune toxicities which is the key issue. Further studies are necessary to identify tumor associated regulatory cells which will enhance the depletion of specific regulatory cells but not the global population of regulatory cells.
ER -
MUTHU RAJA, Karthick Raja and Roman HÁJEK. Regulatory Cells and Multiple Myeloma. In Ajay Gupta. \textit{Multiple Myeloma - An Overview}. Rijeka: InTech, 2012, p.~33-60. Oncology. ISBN~978-953-307-768-0.
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