Detailed Information on Publication Record
2012
Regulatory Cells and Multiple Myeloma
MUTHU RAJA, Karthick Raja and Roman HÁJEKBasic information
Original name
Regulatory Cells and Multiple Myeloma
Authors
MUTHU RAJA, Karthick Raja (356 India, guarantor, belonging to the institution) and Roman HÁJEK (203 Czech Republic, belonging to the institution)
Edition
Rijeka, Multiple Myeloma - An Overview, p. 33-60, 28 pp. Oncology, 2012
Publisher
InTech
Other information
Language
English
Type of outcome
Kapitola resp. kapitoly v odborné knize
Field of Study
30200 3.2 Clinical medicine
Country of publisher
Croatia
Confidentiality degree
není předmětem státního či obchodního tajemství
Publication form
printed version "print"
References:
RIV identification code
RIV/00216224:14110/12:00057252
Organization unit
Faculty of Medicine
ISBN
978-953-307-768-0
Keywords in English
Multiple Myeloma; Tumor Cells; Immune System; Regulatory Cells
Změněno: 12/4/2013 17:49, Ing. Mgr. Věra Pospíšilíková
Abstract
V originále
Large evidence is available in hematological malignancies and solid tumors for elevated level of various regulatory and suppressor cells which impede anti-tumor responses. Therefore, targeting the regulatory cells could be a useful strategy to enhance the anti-tumor immunity. Approaches of depletion or inhibition of regulatory cells showed countable benefits in pre-clinical and clinical studies of some cancers including renal cell carcinoma, metastatic melanoma and colorectal carcinoma. Targeting regulatory T cells in a non-specific approach might cause detrimental autoimmune toxicities which is the key issue. Further studies are necessary to identify tumor associated regulatory cells which will enhance the depletion of specific regulatory cells but not the global population of regulatory cells.
Links
| GAP304/10/1395, research and development project |
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| LC06027, research and development project |
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| MSM0021622434, plan (intention) |
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| NS10406, research and development project |
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