| PESCH, Beate, Benjamin KENDZIA, Per GUSTAVSSON, Karl-Heinz JOECKEL, Georg JOHNEN, Hermann POHLABELN, Ann OLSSON, Wolfgang AHRENS, Isabelle Mercedes GROSS, Irene BRUESKE, Heinz-Erich WICHMANN, Franco MERLETTI, Lorenzo RICHIARDI, Lorenzo SIMONATO, Cristina FORTES, Jack SIEMIATYCKI, Marie-Elise PARENT, Dario CONSONNI, Maria Teresa LANDI, Neil CAPORASO, David ZARIDZE, Adrian CASSIDY, Neonila SZESZENIA-DABROWSKA, Peter RUDNAI, Jolanta LISSOWSKA, Isabelle STUECKER, Eleonora FABIANOVA, Rodica Stanescu DUMITRU, Vladimír BENCKO, Lenka FORETOVÁ, Vladimír JANOUT, Charles M RUDIN, Paul BRENNAN, Paolo BOFFETTA, Kurt STRAIF and Thomas BRUENING. Cigarette smoking and lung cancerurelative risk estimates for the major histological types from a pooled analysis of case-control studies. International journal of cancer. United States: Wiley-Liss, 2012, vol. 131, No 5, p. 1210-1219. ISSN 0020-7136. Available from: https://dx.doi.org/10.1002/ijc.27339. |
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@article{969145,
author = {Pesch, Beate and Kendzia, Benjamin and Gustavsson, Per and Joeckel, KarlandHeinz and Johnen, Georg and Pohlabeln, Hermann and Olsson, Ann and Ahrens, Wolfgang and Gross, Isabelle Mercedes and Brueske, Irene and Wichmann, HeinzandErich and Merletti, Franco and Richiardi, Lorenzo and Simonato, Lorenzo and Fortes, Cristina and Siemiatycki, Jack and Parent, MarieandElise and Consonni, Dario and Landi, Maria Teresa and Caporaso, Neil and Zaridze, David and Cassidy, Adrian and SzeszeniaandDabrowska, Neonila and Rudnai, Peter and Lissowska, Jolanta and Stuecker, Isabelle and Fabianova, Eleonora and Dumitru, Rodica Stanescu and Bencko, Vladimír and Foretová, Lenka and Janout, Vladimír and Rudin, Charles M and Brennan, Paul and Boffetta, Paolo and Straif, Kurt and Bruening, Thomas},
article_location = {United States},
article_number = {5},
doi = {http://dx.doi.org/10.1002/ijc.27339},
keywords = {cigarette smoking; lung cancer; relative risk characterization; tobacco smoke; stem cells},
language = {eng},
issn = {0020-7136},
journal = {International journal of cancer},
title = {Cigarette smoking and lung cancerurelative risk estimates for the major histological types from a pooled analysis of case-control studies},
volume = {131},
year = {2012}
}
TY - JOUR
ID - 969145
AU - Pesch, Beate - Kendzia, Benjamin - Gustavsson, Per - Joeckel, Karl-Heinz - Johnen, Georg - Pohlabeln, Hermann - Olsson, Ann - Ahrens, Wolfgang - Gross, Isabelle Mercedes - Brueske, Irene - Wichmann, Heinz-Erich - Merletti, Franco - Richiardi, Lorenzo - Simonato, Lorenzo - Fortes, Cristina - Siemiatycki, Jack - Parent, Marie-Elise - Consonni, Dario - Landi, Maria Teresa - Caporaso, Neil - Zaridze, David - Cassidy, Adrian - Szeszenia-Dabrowska, Neonila - Rudnai, Peter - Lissowska, Jolanta - Stuecker, Isabelle - Fabianova, Eleonora - Dumitru, Rodica Stanescu - Bencko, Vladimír - Foretová, Lenka - Janout, Vladimír - Rudin, Charles M - Brennan, Paul - Boffetta, Paolo - Straif, Kurt - Bruening, Thomas
PY - 2012
TI - Cigarette smoking and lung cancerurelative risk estimates for the major histological types from a pooled analysis of case-control studies
JF - International journal of cancer
VL - 131
IS - 5
SP - 1210-1219
EP - 1210-1219
PB - Wiley-Liss
SN - 00207136
KW - cigarette smoking
KW - lung cancer
KW - relative risk characterization
KW - tobacco smoke
KW - stem cells
N2 - Lung cancer is mainly caused by smoking, but the quantitative relations between smoking and histologic subtypes of lung cancer remain inconclusive. By using one of the largest lung cancer datasets ever assembled, we explored the impact of smoking on risks of the major cell types of lung cancer. This pooled analysis included 13,169 cases and 16,010 controls from Europe and Canada. Studies with population controls comprised 66.5% of the subjects. Adenocarcinoma (AdCa) was the most prevalent subtype in never smokers and in women. Squamous cell carcinoma (SqCC) predominated in male smokers. Age-adjusted odds ratios (ORs) were estimated with logistic regression. ORs were elevated for all metrics of exposure to cigarette smoke and were higher for SqCC and small cell lung cancer (SCLC) than for AdCa. Current male smokers with an average daily dose of >30 cigarettes had ORs of 103.5 (95% confidence interval (CI): 74.8143.2) for SqCC, 111.3 (95% CI: 69.8177.5) for SCLC and 21.9 (95% CI: 16.629.0) for AdCa. In women, the corresponding ORs were 62.7 (95% CI: 31.5124.6), 108.6 (95% CI: 50.7232.8) and 16.8 (95% CI: 9.230.6), respectively. Although ORs started to decline soon after quitting, they did not fully return to the baseline risk of never smokers even 35 years after cessation. The major result that smoking exerted a steeper risk gradient on SqCC and SCLC than on AdCa is in line with previous population data and biological understanding of lung cancer development.
ER -
PESCH, Beate, Benjamin KENDZIA, Per GUSTAVSSON, Karl-Heinz JOECKEL, Georg JOHNEN, Hermann POHLABELN, Ann OLSSON, Wolfgang AHRENS, Isabelle Mercedes GROSS, Irene BRUESKE, Heinz-Erich WICHMANN, Franco MERLETTI, Lorenzo RICHIARDI, Lorenzo SIMONATO, Cristina FORTES, Jack SIEMIATYCKI, Marie-Elise PARENT, Dario CONSONNI, Maria Teresa LANDI, Neil CAPORASO, David ZARIDZE, Adrian CASSIDY, Neonila SZESZENIA-DABROWSKA, Peter RUDNAI, Jolanta LISSOWSKA, Isabelle STUECKER, Eleonora FABIANOVA, Rodica Stanescu DUMITRU, Vladimír BENCKO, Lenka FORETOVÁ, Vladimír JANOUT, Charles M RUDIN, Paul BRENNAN, Paolo BOFFETTA, Kurt STRAIF and Thomas BRUENING. Cigarette smoking and lung cancerurelative risk estimates for the major histological types from a pooled analysis of case-control studies. \textit{International journal of cancer}. United States: Wiley-Liss, 2012, vol.~131, No~5, p.~1210-1219. ISSN~0020-7136. Available from: https://dx.doi.org/10.1002/ijc.27339.
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