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@article{969147,
author = {'t Mannetje, A. and Bencko, V. and Brennan, P. and Zaridze, D. and SzeszeniaandDabrowska, N. and Rudnai, P. and Lissowska, J. and Fabianova, E. and Cassidy, A. and Mates, D. and Foretová, Lenka and Janout, Vladimír and Fevotte, J. and Fletcher, T. and Boffetta, P.},
article_location = {Netherlands},
article_number = {12},
doi = {http://dx.doi.org/10.1007/s10552-011-9843-3},
keywords = {Lung neoplasms; Occupational exposure; Metals; Case-control study; Confounding},
language = {eng},
issn = {0957-5243},
journal = {Cancer causes and control},
title = {Occupational exposure to metal compounds and lung cancer. Results from a multi-center case-control study in Central/Eastern Europe and UK},
volume = {22},
year = {2011}
}
TY - JOUR
ID - 969147
AU - 't Mannetje, A. - Bencko, V. - Brennan, P. - Zaridze, D. - Szeszenia-Dabrowska, N. - Rudnai, P. - Lissowska, J. - Fabianova, E. - Cassidy, A. - Mates, D. - Foretová, Lenka - Janout, Vladimír - Fevotte, J. - Fletcher, T. - Boffetta, P.
PY - 2011
TI - Occupational exposure to metal compounds and lung cancer. Results from a multi-center case-control study in Central/Eastern Europe and UK
JF - Cancer causes and control
VL - 22
IS - 12
SP - 1669-1680
EP - 1669-1680
PB - Kluwer Academic Publishers
SN - 09575243
KW - Lung neoplasms
KW - Occupational exposure
KW - Metals
KW - Case-control study
KW - Confounding
N2 - To study the association between occupational exposure to metals including chromium, cadmium, nickel, and arsenic compounds, within a population-based study design, while adjusting for confounding factors. Methods A population-based lung cancer case-control study in Central/Eastern Europe and UK was conducted in 1998-2003, including 2,853 cases and 3,104 controls. Exposure to 70 occupational agents was assessed by local expert-teams for all subjects. Odds ratios (OR) for exposure to dust and fumes/mist of chromium, nickel, cadmium, arsenic, as well as inorganic pigment dust and inorganic acid mist, were adjusting for smoking, age, center, sex, and exposure to other occupational agents including the metals under study. Results Exposure to arsenic (prevalence = 1.4%) was associated with an increased lung cancer risk ((OR) 1.65, 95% confidence interval (95% CI): 1.05-2.58). For chromium dust (prevalence = 4.8%, OR: 1.25, 95% CI: 0.95-1.65), a linear upward trend for duration and cumulative exposure was observed. A weak association was observed for exposure to cadmium fumes (prevalence = 1.8%, OR: 1.19, 95% CI: 0.77-1.82), which was strongest for the highest category of cumulative exposure (OR: 2.04, 95% CI: 1.07-3.90). No increased risk was observed for inorganic acid mist, inorganic pigment dust, or nickel, after adjustment for other metals. An independent effect of nickel cannot be excluded, due to its collinearity with chromium exposure. Conclusions Occupational exposure to metals is an important risk factor for lung cancer. Although the strongest risk was observed for arsenic, exposure to chromium dust was most important in terms of attributable risk due to its high prevalence.
ER -
'T MANNETJE, A., V. BENCKO, P. BRENNAN, D. ZARIDZE, N. SZESZENIA-DABROWSKA, P. RUDNAI, J. LISSOWSKA, E. FABIANOVA, A. CASSIDY, D. MATES, Lenka FORETOVÁ, Vladimír JANOUT, J. FEVOTTE, T. FLETCHER a P. BOFFETTA. Occupational exposure to metal compounds and lung cancer. Results from a multi-center case-control study in Central/Eastern Europe and UK. \textit{Cancer causes and control}. Netherlands: Kluwer Academic Publishers, 2011, roč.~22, č.~12, s.~1669-1680. ISSN~0957-5243. Dostupné z: https://dx.doi.org/10.1007/s10552-011-9843-3.
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