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@article{969149, author = {Campa, Daniele and Butterbach, Katja and Slager, Susan L and Skibola, Christine F and de Sanjose, Silvia and Benavente, Yolanda and Becker, Nikolaus and Foretová, Lenka and Maynadie, Marc and Cocco, Pierluigi and Staines, Anthony and Kaaks, Rudolf and Boffetta, Paolo and Brennan, Paul and Conde, Lucia and Bracci, Paige M and Caporaso, Neil E and Strom, Sara S and Camp, Nicola J and Cerhan, James R and Canzian, Federico and Nieters, Alexandra}, article_location = {United States}, article_number = {4}, doi = {http://dx.doi.org/10.1002/ijc.26436}, keywords = {lymphoma; multidrug resistance 1; multidrug resistance protein 2; breast cancer resistance protein; pregnane x receptor}, language = {eng}, issn = {0020-7136}, journal = {International journal of cancer}, title = {A comprehensive study of polymorphisms in the ABCB1, ABCC2, ABCG2, NR1I2 genes and lymphoma risk}, volume = {131}, year = {2012} }
TY - JOUR ID - 969149 AU - Campa, Daniele - Butterbach, Katja - Slager, Susan L - Skibola, Christine F - de Sanjose, Silvia - Benavente, Yolanda - Becker, Nikolaus - Foretová, Lenka - Maynadie, Marc - Cocco, Pierluigi - Staines, Anthony - Kaaks, Rudolf - Boffetta, Paolo - Brennan, Paul - Conde, Lucia - Bracci, Paige M - Caporaso, Neil E - Strom, Sara S - Camp, Nicola J - Cerhan, James R - Canzian, Federico - Nieters, Alexandra PY - 2012 TI - A comprehensive study of polymorphisms in the ABCB1, ABCC2, ABCG2, NR1I2 genes and lymphoma risk JF - International journal of cancer VL - 131 IS - 4 SP - 803-812 EP - 803-812 PB - Wiley-Liss SN - 00207136 KW - lymphoma KW - multidrug resistance 1 KW - multidrug resistance protein 2 KW - breast cancer resistance protein KW - pregnane x receptor N2 - Owing to their role in controlling the efflux of toxic compounds, transporters are central players in the process of detoxification and elimination of xenobiotics, which in turn is related to cancer risk. Among these transporters, ATP-binding cassette B1/multidrug resistance 1 (ABCB1/MDR1), ABCC2/multidrug resistance protein 2 (MRP2) and ABCG2/breast cancer resistance protein (BCRP) affect susceptibility to many hematopoietic malignancies. The maintenance of regulated expression of these transporters is governed through the activation of intracellular xenosensors like the nuclear receptor 1I2/pregnane X receptor (NR1I2/PXR). SNPs in genes encoding these regulators have also been implicated in the risk of several cancers. Using a tagging approach, we tested the hypothesis that common polymorphisms in the transporter genes ABCB1, ABCC2, ABCG2 and the regulator gene NR1I2 could be implicated in lymphoma risk. We selected 68 SNPs in the four genes, and we genotyped them in 1,481 lymphoma cases and 1,491 controls of the European casecontrol study (EpiLymph) using the Illumina GoldenGate (TM) assay technology. Carriers of the SNP rs6857600 minor allele in ABCG2 was associated with a decrease in risk of B-cell lymphoma (B-NHL) overall (p < 0.001). Furthermore, a decreased risk of chronic lymphocytic leukemia (CLL) was associated with the ABCG2 rs2231142 variant (p = 0.0004), which could be replicated in an independent population. These results suggest a role for this gene in B-NHL susceptibility, especially for CLL. ER -
CAMPA, Daniele, Katja BUTTERBACH, Susan L SLAGER, Christine F SKIBOLA, Silvia DE SANJOSE, Yolanda BENAVENTE, Nikolaus BECKER, Lenka FORETOVÁ, Marc MAYNADIE, Pierluigi COCCO, Anthony STAINES, Rudolf KAAKS, Paolo BOFFETTA, Paul BRENNAN, Lucia CONDE, Paige M BRACCI, Neil E CAPORASO, Sara S STROM, Nicola J CAMP, James R CERHAN, Federico CANZIAN a Alexandra NIETERS. A comprehensive study of polymorphisms in the ABCB1, ABCC2, ABCG2, NR1I2 genes and lymphoma risk. \textit{International journal of cancer}. United States: Wiley-Liss, roč.~131, č.~4, s.~803-812. ISSN~0020-7136. doi:10.1002/ijc.26436. 2012.
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