CAMPA, Daniele, Katja BUTTERBACH, Susan L SLAGER, Christine F SKIBOLA, Silvia DE SANJOSE, Yolanda BENAVENTE, Nikolaus BECKER, Lenka FORETOVÁ, Marc MAYNADIE, Pierluigi COCCO, Anthony STAINES, Rudolf KAAKS, Paolo BOFFETTA, Paul BRENNAN, Lucia CONDE, Paige M BRACCI, Neil E CAPORASO, Sara S STROM, Nicola J CAMP, James R CERHAN, Federico CANZIAN a Alexandra NIETERS. A comprehensive study of polymorphisms in the ABCB1, ABCC2, ABCG2, NR1I2 genes and lymphoma risk. International journal of cancer. United States: Wiley-Liss, roč. 131, č. 4, s. 803-812. ISSN 0020-7136. doi:10.1002/ijc.26436. 2012.
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Základní údaje
Originální název A comprehensive study of polymorphisms in the ABCB1, ABCC2, ABCG2, NR1I2 genes and lymphoma risk
Autoři CAMPA, Daniele, Katja BUTTERBACH, Susan L SLAGER, Christine F SKIBOLA, Silvia DE SANJOSE, Yolanda BENAVENTE, Nikolaus BECKER, Lenka FORETOVÁ, Marc MAYNADIE, Pierluigi COCCO, Anthony STAINES, Rudolf KAAKS, Paolo BOFFETTA, Paul BRENNAN, Lucia CONDE, Paige M BRACCI, Neil E CAPORASO, Sara S STROM, Nicola J CAMP, James R CERHAN, Federico CANZIAN a Alexandra NIETERS.
Vydání International journal of cancer, United States, Wiley-Liss, 2012, 0020-7136.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 30200 3.2 Clinical medicine
Stát vydavatele Spojené státy
Utajení není předmětem státního či obchodního tajemství
Impakt faktor Impact factor: 6.198
Organizační jednotka Lékařská fakulta
Doi http://dx.doi.org/10.1002/ijc.26436
UT WoS 000305451300031
Klíčová slova anglicky lymphoma; multidrug resistance 1; multidrug resistance protein 2; breast cancer resistance protein; pregnane x receptor
Příznaky Mezinárodní význam
Změnil Změnila: Soňa Böhmová, učo 232884. Změněno: 23. 4. 2014 14:29.
Anotace
Owing to their role in controlling the efflux of toxic compounds, transporters are central players in the process of detoxification and elimination of xenobiotics, which in turn is related to cancer risk. Among these transporters, ATP-binding cassette B1/multidrug resistance 1 (ABCB1/MDR1), ABCC2/multidrug resistance protein 2 (MRP2) and ABCG2/breast cancer resistance protein (BCRP) affect susceptibility to many hematopoietic malignancies. The maintenance of regulated expression of these transporters is governed through the activation of intracellular xenosensors like the nuclear receptor 1I2/pregnane X receptor (NR1I2/PXR). SNPs in genes encoding these regulators have also been implicated in the risk of several cancers. Using a tagging approach, we tested the hypothesis that common polymorphisms in the transporter genes ABCB1, ABCC2, ABCG2 and the regulator gene NR1I2 could be implicated in lymphoma risk. We selected 68 SNPs in the four genes, and we genotyped them in 1,481 lymphoma cases and 1,491 controls of the European casecontrol study (EpiLymph) using the Illumina GoldenGate (TM) assay technology. Carriers of the SNP rs6857600 minor allele in ABCG2 was associated with a decrease in risk of B-cell lymphoma (B-NHL) overall (p < 0.001). Furthermore, a decreased risk of chronic lymphocytic leukemia (CLL) was associated with the ABCG2 rs2231142 variant (p = 0.0004), which could be replicated in an independent population. These results suggest a role for this gene in B-NHL susceptibility, especially for CLL.
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