| CHEN, D., T. TRUONG, V. GABORIEAU, G. BYRNES, A. CHABRIER, Shu-chun CHUANG, A. OLSHAN, M. WEISSLER, J. LUO, M. ROMKES, S. BUCH, T. NUKUI, S. FRANCESCHI, R. HERRERO, R. TALAMINI, K. KELSEY, B. CHRISTENSEN, M. MCCLEAN, M. LACKO, J. MANNI, W. PETERS, J. LUBINSKI, J. TRUBICKA, M. LENER, J. MUSCAT, P. LAZARUS, Q. WEI, E. STURGIS, Zuo-Feng ZHANG, Shen-Chih CHANG, R. WANG, S. SCHWARTZ, Chu CHEN, S. BENHAMOU, P. LAGIOU, I. HOLCATOV, L. RICHIARDI, K. KJAERHEIM, A. AGUDO, X. CASTELLSAGUE, T. MACFARLANE, L. BARZAN, Ch. CANOVA, N. THAKKER, D. CONWAY, A. ZNAOR, C. HEALY, W. AHRENS, D. ZARIDZE, N. SZESZENIA-DABROWSKA, J. LISSOWSKA, E. FABIANOVA, A. BUCUR, V. BENCKO, Lenka FORETOVÁ, V. JANOUT, M. CURADO, S. KOIFMAN, A. MENEZES, V. WUENSCH-FILHO, J. ELUF-NETO, L. FERNANDEZ, S. BOCCIA, M. HASHIBE, R. HAYES, P. BOFFETTA, P. BRENNAN a J. MCKAY. A sex-specific association between a 15q25 variant and upper aerodigestive tract cancers. Cancer epidemiology, biomarkers and prevention. United States: American Association for Cancer Research, roč. 20, č. 4, s. 658-664. ISSN 1055-9965. doi:10.1158/1055-9965.EPI-10-1008. 2011. |
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@article{969163,
author = {Chen, D. and Truong, T. and Gaborieau, V. and Byrnes, G. and Chabrier, A. and Chuang, Shuandchun and Olshan, A. and Weissler, M. and Luo, J. and Romkes, M. and Buch, S. and Nukui, T. and Franceschi, S. and Herrero, R. and Talamini, R. and Kelsey, K. and Christensen, B. and McClean, M. and Lacko, M. and Manni, J. and Peters, W. and Lubinski, J. and Trubicka, J. and Lener, M. and Muscat, J. and Lazarus, P. and Wei, Q. and Sturgis, E. and Zhang, ZuoandFeng and Chang, ShenandChih and Wang, R. and Schwartz, S. and Chen, Chu and Benhamou, S. and Lagiou, P. and Holcatov, I. and Richiardi, L. and Kjaerheim, K. and Agudo, A. and Castellsague, X. and Macfarlane, T. and Barzan, L. and Canova, Ch. and Thakker, N. and Conway, D. and Znaor, A. and Healy, C. and Ahrens, W. and Zaridze, D. and SzeszeniaandDabrowska, N. and Lissowska, J. and Fabianova, E. and Bucur, A. and Bencko, V. and Foretová, Lenka and Janout, V. and Curado, M. and Koifman, S. and Menezes, A. and WuenschandFilho, V. and ElufandNeto, J. and Fernandez, L. and Boccia, S. and Hashibe, M. and Hayes, R. and Boffetta, P. and Brennan, P. and McKay, J.},
article_location = {United States},
article_number = {4},
doi = {http://dx.doi.org/10.1158/1055-9965.EPI-10-1008},
keywords = {NICOTINIC ACETYLCHOLINE-RECEPTORS; LUNG-CANCER; SUSCEPTIBILITY LOCUS; RISK; DEPENDENCE; EXPRESSION; GENES; AGE},
language = {eng},
issn = {1055-9965},
journal = {Cancer epidemiology, biomarkers and prevention},
title = {A sex-specific association between a 15q25 variant and upper aerodigestive tract cancers},
volume = {20},
year = {2011}
}
TY - JOUR
ID - 969163
AU - Chen, D. - Truong, T. - Gaborieau, V. - Byrnes, G. - Chabrier, A. - Chuang, Shu-chun - Olshan, A. - Weissler, M. - Luo, J. - Romkes, M. - Buch, S. - Nukui, T. - Franceschi, S. - Herrero, R. - Talamini, R. - Kelsey, K. - Christensen, B. - McClean, M. - Lacko, M. - Manni, J. - Peters, W. - Lubinski, J. - Trubicka, J. - Lener, M. - Muscat, J. - Lazarus, P. - Wei, Q. - Sturgis, E. - Zhang, Zuo-Feng - Chang, Shen-Chih - Wang, R. - Schwartz, S. - Chen, Chu - Benhamou, S. - Lagiou, P. - Holcatov, I. - Richiardi, L. - Kjaerheim, K. - Agudo, A. - Castellsague, X. - Macfarlane, T. - Barzan, L. - Canova, Ch. - Thakker, N. - Conway, D. - Znaor, A. - Healy, C. - Ahrens, W. - Zaridze, D. - Szeszenia-Dabrowska, N. - Lissowska, J. - Fabianova, E. - Bucur, A. - Bencko, V. - Foretová, Lenka - Janout, V. - Curado, M. - Koifman, S. - Menezes, A. - Wuensch-Filho, V. - Eluf-Neto, J. - Fernandez, L. - Boccia, S. - Hashibe, M. - Hayes, R. - Boffetta, P. - Brennan, P. - McKay, J.
PY - 2011
TI - A sex-specific association between a 15q25 variant and upper aerodigestive tract cancers
JF - Cancer epidemiology, biomarkers and prevention
VL - 20
IS - 4
SP - 658-664
EP - 658-664
PB - American Association for Cancer Research
SN - 10559965
KW - NICOTINIC ACETYLCHOLINE-RECEPTORS
KW - LUNG-CANCER
KW - SUSCEPTIBILITY LOCUS
KW - RISK
KW - DEPENDENCE
KW - EXPRESSION
KW - GENES
KW - AGE
N2 - Sequence variants located at 15q25 have been associated with lung cancer and propensity to smoke. We recently reported an association between rs16969968 and risk of upper aerodigestive tract (UADT) cancers (oral cavity, oropharynx, hypopharynx, larynx, and esophagus) in women (OR = 1.24, P = 0.003) with little effect in men (OR = 1.04, P = 0.35). Methods: In a coordinated genotyping study within the International Head and Neck Cancer Epidemiology (INHANCE) consortium, we have sought to replicate these findings in an additional 4,604 cases and 6,239 controls from 10 independent UADT cancer case-control studies. Results: rs16969968 was again associated with UADT cancers in women (OR = 1.21, 95% CI = 1.08-1.36, P = 0.001) and a similar lack of observed effect in men [OR = 1.02, 95% CI = 0.95-1.09, P = 0.66; P-heterogeneity (P(het)) = 0.01]. In a pooled analysis of the original and current studies, totaling 8,572 UADT cancer cases and 11,558 controls, the association was observed among females (OR = 1.22, 95% CI = 1.12-1.34, P = 7 x 10(-6)) but not males (OR = 1.02, 95% CI = 0.97-1.08, P = 0.35; P(het) = 6 x 10(-4)). There was little evidence for a sex difference in the association between this variant and cigarettes smoked per day, with male and female rs16969968 variant carriers smoking approximately the same amount more in the 11,991 ever smokers in the pooled analysis of the 14 studies (P(het) = 0.86). Conclusions: This study has confirmed a sex difference in the association between the 15q25 variant rs16969968 and UADT cancers.
ER -
CHEN, D., T. TRUONG, V. GABORIEAU, G. BYRNES, A. CHABRIER, Shu-chun CHUANG, A. OLSHAN, M. WEISSLER, J. LUO, M. ROMKES, S. BUCH, T. NUKUI, S. FRANCESCHI, R. HERRERO, R. TALAMINI, K. KELSEY, B. CHRISTENSEN, M. MCCLEAN, M. LACKO, J. MANNI, W. PETERS, J. LUBINSKI, J. TRUBICKA, M. LENER, J. MUSCAT, P. LAZARUS, Q. WEI, E. STURGIS, Zuo-Feng ZHANG, Shen-Chih CHANG, R. WANG, S. SCHWARTZ, Chu CHEN, S. BENHAMOU, P. LAGIOU, I. HOLCATOV, L. RICHIARDI, K. KJAERHEIM, A. AGUDO, X. CASTELLSAGUE, T. MACFARLANE, L. BARZAN, Ch. CANOVA, N. THAKKER, D. CONWAY, A. ZNAOR, C. HEALY, W. AHRENS, D. ZARIDZE, N. SZESZENIA-DABROWSKA, J. LISSOWSKA, E. FABIANOVA, A. BUCUR, V. BENCKO, Lenka FORETOVÁ, V. JANOUT, M. CURADO, S. KOIFMAN, A. MENEZES, V. WUENSCH-FILHO, J. ELUF-NETO, L. FERNANDEZ, S. BOCCIA, M. HASHIBE, R. HAYES, P. BOFFETTA, P. BRENNAN a J. MCKAY. A sex-specific association between a 15q25 variant and upper aerodigestive tract cancers. \textit{Cancer epidemiology, biomarkers and prevention}. United States: American Association for Cancer Research, roč.~20, č.~4, s.~658-664. ISSN~1055-9965. doi:10.1158/1055-9965.EPI-10-1008. 2011.
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