Další formáty:
BibTeX
LaTeX
RIS
@proceedings{969488,
author = {Ševčíková, Sabina and Kryukov, Fedor and Dementyeva, Elena Vladimirovna and Kubiczková, Lenka and Němec, Pavel and Adam, Zdeněk and Hájek, Roman},
booktitle = {53rd ASH Annual Meeting and Exposition},
keywords = {multiple myeloma; B cell; centrosom},
language = {eng},
title = {Centrosomal Disruption As Early Event in Myeloma Development},
year = {2011}
}
TY - CONF
ID - 969488
AU - Ševčíková, Sabina - Kryukov, Fedor - Dementyeva, Elena Vladimirovna - Kubiczková, Lenka - Němec, Pavel - Adam, Zdeněk - Hájek, Roman
PY - 2011
TI - Centrosomal Disruption As Early Event in Myeloma Development
KW - multiple myeloma
KW - B cell
KW - centrosom
N2 - Multiple myeloma (MM) is a malignancy of differentiated B-lymphocytes characterized by accumulation of clonal plasma cells (PCs) in the bone marrow. Genome of malignant PCs is extremely unstable and characterized by complex combination of structural and numerical abnormalities. The basis of genomic instability underlying MM is still unclear. Centrosome amplification (CA) is present in about a third of MM cases and may represent a mechanism leading to genomic instability in myeloma. We have previously shown that CA is present in pre-plasma cells stages of B-cell development. Aims: The objective of our study was to evaluate changes in expression of chosen key genes involved in centrosome duplication process in both B and PCs, including their possible changes during MM progression.
ER -
ŠEVČÍKOVÁ, Sabina, Fedor KRYUKOV, Elena Vladimirovna DEMENTYEVA, Lenka KUBICZKOVÁ, Pavel NĚMEC, Zdeněk ADAM a Roman HÁJEK. Centrosomal Disruption As Early Event in Myeloma Development. In \textit{53rd ASH Annual Meeting and Exposition}. 2011.
|
