The effects of methamphetamine self-administration on
behavioural sensitization in the olfactory bulbectomy rat model
of depression

J 2012

The effects of methamphetamine self-administration on behavioural sensitization in the olfactory bulbectomy rat model of depression

KUČEROVÁ, Jana, Jana PISTOVČÁKOVÁ, Dagmar VRŠKOVÁ, Ladislav DUŠEK, Alexandra ŠULCOVÁ et. al.

Basic information

Original name

The effects of methamphetamine self-administration on behavioural sensitization in the olfactory bulbectomy rat model of depression

Name in Czech

Vliv operantní autoaplikace metamfetaminu na behaviorální senzitiaci v potkaním modelu deprese navozené olfaktorickou bulbektomií

Authors

KUČEROVÁ, Jana (203 Czech Republic, guarantor, belonging to the institution), Jana PISTOVČÁKOVÁ (203 Czech Republic, belonging to the institution), Dagmar VRŠKOVÁ (203 Czech Republic), Ladislav DUŠEK (203 Czech Republic, belonging to the institution) and Alexandra ŠULCOVÁ (203 Czech Republic, belonging to the institution)

Edition

The International Journal of Neuropsychopharmacology, New York, Cambridge University Press, 2012, 1461-1457

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.641

RIV identification code

RIV/00216224:14740/12:00059286

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1017/S1461145711001684

UT WoS

000309740200011

Keywords (in Czech)

metamfetamin; operantní autoaplikace; olfaktorická bulbektomie; deprese; potkan Wistar

Keywords in English

methamphetamine; IV Self-administration; olfactory bulbectomy model; depression; Wistar rats

Abstract

V originále

Depression is frequently comorbid with a drug addiction and may seriously complicate its treatment. Currently, there is no routinely used animal model to investigate this comorbidity. In this study the effect of repeated administration of methamphetamine on i.v. drug self-administration in an olfactory bulbectomy model of depression in rats was investigated in order to propose and validate a rat model of comorbid depression and addiction. Male Wistar rats were either olfactory-bulbectomized (OBX) or sham-operated. They subsequently underwent a methamphetamine sensitization regime, which consisted of daily i.p. injections of methamphetamine for a 14-d period; controls received Sal injections at the same frequency. The i.v. self-administration of methamphetamine (0.08 mg/kg in one infusion) paradigm on a fixed ratio schedule of reinforcement was performed using operant chambers. A significant decrease of the drug intake was recorded in sham-operated animals pretreated with methamphetamine when compared to the unpretreated group. This was not apparent in the OBX groups. Both groups of OBX animals exhibited a higher intake of methamphetamine compared to the corresponding sham-operated groups, thus confirming the hypothesis of higher drug intake in depressive conditions in this rodent model. The procedure of behavioural sensitization to methamphetamine decreased the number of self-administered drug doses per session in the sham-operated rats. It is hypothesized that this phenomenon resulted from increasing efficacy of the drug after behavioural sensitization caused by repeated methamphetamine intermittent administration.

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

MSM0021622404, plan (intention)

Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.

Files attached

Kucerova_11.pdf

Request the author's version of the file

Citovat

KUČEROVÁ, Jana, Jana PISTOVČÁKOVÁ, Dagmar VRŠKOVÁ, Ladislav DUŠEK and Alexandra ŠULCOVÁ. The effects of methamphetamine self-administration on behavioural sensitization in the olfactory bulbectomy rat model of depression. The International Journal of Neuropsychopharmacology. New York: Cambridge University Press, 2012, vol. 15, No 10, p. 1503-1511. ISSN 1461-1457. Available from: https://dx.doi.org/10.1017/S1461145711001684.

@article{970059,
   author = {Kučerová, Jana and Pistovčáková, Jana and Vršková, Dagmar and Dušek, Ladislav and Šulcová, Alexandra},
   article_location = {New York},
   article_number = {10},
   doi = {http://dx.doi.org/10.1017/S1461145711001684},
   keywords = {methamphetamine; IV Self-administration; olfactory bulbectomy model; depression; Wistar rats},
   language = {eng},
   issn = {1461-1457},
   journal = {The International Journal of Neuropsychopharmacology},
   title = {The effects of methamphetamine self-administration on behavioural sensitization in the olfactory bulbectomy rat model of depression},
   url = {http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8704767},
   volume = {15},
   year = {2012}
}

TY  - JOUR
ID  - 970059
AU  - Kučerová, Jana - Pistovčáková, Jana - Vršková, Dagmar - Dušek, Ladislav - Šulcová, Alexandra
PY  - 2012
TI  - The effects of methamphetamine self-administration on behavioural sensitization in the olfactory bulbectomy rat model of depression
JF  - The International Journal of Neuropsychopharmacology
VL  - 15
IS  - 10
SP  - 1503-1511
EP  - 1503-1511
PB  - Cambridge University Press
SN  - 14611457
KW  - methamphetamine
KW  - IV Self-administration
KW  - olfactory bulbectomy model
KW  - depression
KW  - Wistar rats
UR  - http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8704767
L2  - http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8704767
N2  - Depression is frequently comorbid with a drug addiction and may seriously complicate its treatment. Currently, there is no routinely used animal model to investigate this comorbidity. In this study the effect of repeated administration of methamphetamine on i.v. drug self-administration in an olfactory bulbectomy model of depression in rats was investigated in order to propose and validate a rat model of comorbid depression and addiction. Male Wistar rats were either olfactory-bulbectomized (OBX) or sham-operated. They subsequently underwent a methamphetamine sensitization regime, which consisted of daily i.p. injections of methamphetamine for a 14-d period; controls received Sal injections at the same frequency. The i.v. self-administration of methamphetamine (0.08 mg/kg in one infusion) paradigm on a fixed ratio schedule of reinforcement was performed using operant chambers. A significant decrease of the drug intake was recorded in sham-operated animals pretreated with methamphetamine when compared to the unpretreated group. This was not apparent in the OBX groups. Both groups of OBX animals exhibited a higher intake of methamphetamine compared to the corresponding sham-operated groups, thus confirming the hypothesis of higher drug intake in depressive conditions in this rodent model. The procedure of behavioural sensitization to methamphetamine decreased the number of self-administered drug doses per session in the sham-operated rats. It is hypothesized that this phenomenon resulted from increasing efficacy of the drug after behavioural sensitization caused by repeated methamphetamine intermittent administration.
ER  -

KUČEROVÁ, Jana, Jana PISTOVČÁKOVÁ, Dagmar VRŠKOVÁ, Ladislav DUŠEK and Alexandra ŠULCOVÁ. The effects of methamphetamine self-administration on behavioural sensitization in the olfactory bulbectomy rat model of depression. \textit{The International Journal of Neuropsychopharmacology}. New York: Cambridge University Press, 2012, vol.~15, No~10, p.~1503-1511. ISSN~1461-1457. Available from: https://dx.doi.org/10.1017/S1461145711001684.

Detailed Information on Publication Record