ONDRUŠ, Šimon, M. STRAKA and Jaroslava BAJEROVÁ. Tricalcium Phosphate Mixed with Autologous Bone Marrow in the Treatment of Benign Cystic Bone Lesions in Children. Acta Chirurgiae Orthopaedicae et Traumatologiae Čechoslovaca. 2011, vol. 78, No 6, p. 544-550. ISSN 0001-5415.
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Basic information
Original name Tricalcium Phosphate Mixed with Autologous Bone Marrow in the Treatment of Benign Cystic Bone Lesions in Children
Authors ONDRUŠ, Šimon (203 Czech Republic, guarantor, belonging to the institution), M. STRAKA (203 Czech Republic) and Jaroslava BAJEROVÁ (203 Czech Republic, belonging to the institution).
Edition Acta Chirurgiae Orthopaedicae et Traumatologiae Čechoslovaca, 2011, 0001-5415.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30000 3. Medical and Health Sciences
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.628 in 2009
RIV identification code RIV/00216224:14110/11:00055478
Organization unit Faculty of Medicine
UT WoS 000298771400009
Keywords in English benign cystic lesion; bone; tricalcium phosphate; child
Tags International impact
Changed by Changed by: Mgr. Michal Petr, učo 65024. Changed: 9/2/2012 10:30.
Abstract
The prospective study included two groups, each consisting of 10 patients, treated for benign cystic bone lesions at the Department of Paediatric Surgery, Orthopaedics and Trauma Surgery from July 1, 2008 to June 30, 2010. The bone cysts involved non-ossifying fibroma, enchodroma, fibrous dysplasia, aneurysmal bone cyst and juvenile bone cyst. One group was treated using ChronOS(TM) Beta-Tricalcium Phosphate (Synthes GmbH, Switzerland) granules mixed with autologous bone marrow harvested during surgery (BM group). The other (CH group) received treatment with ChronOS granules alone. Relevant clinical data were obtained from all 20 patients treated for one of the bone cyst forms mentioned above. The patients were followed up till the end of 2010. RESULTS TOP application was a one-step procedure in both groups. In the BM group, bone regeneration ad integrum (Neer 1) was achieved, with only an occasional very small residue of the cyst seen on radiographs (Neer 2). None of the patients reported any problems, not even at 6 months after surgery. In the CH group, two patients required further surgical treatment because of insufficient bone healing (Neer 3) and two other patients reported pain persisting at the site of the lesion at 6 months post-operatively. In these patients TOP was used to fill a defect after excochleation of an aneurysmal bone cyst or fibrous dysplasia. The rest of the patients showed satisfactory healing. DISCUSSION The main objective of the use of synthetic biocompatible materials in surgical treatment of benign bone cysts requiring filling of the lesion is to reduce the post-operative stress of paediatric patients as much as possible. Although our first results were not statistically significant to give unambiguous support to our hypothesis that lesions would heal better with the use of synthetic tricalcium phosphate mixed with autologous bone marrow, there is plenty of evidence that further development of cell technologies will result in a more exact definition of bone substitute materials in both their components, i.e., well-defined cells and non-biological scaffolds close in structure to inorganic compounds of bone, i.e., biodegradable osteoinductive materials. CONCLUSIONS The patients with benign bone lesions treated by TOP mixed with autologous bone marrow showed neither recurrent disease nor complications. The group treated with TOP alone had recurrent lesions in two and persisting pain also in two patients. Other complications were not recorded.
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