The Role of the Inferior Frontal Gyri in Cognitive Processing of Patients with Parkinson's Disease: A Pilot rTMS Study

SROVNALOVÁ, Hana, Radek MAREČEK and Irena REKTOROVÁ. The Role of the Inferior Frontal Gyri in Cognitive Processing of Patients with Parkinson's Disease: A Pilot rTMS Study. MOVEMENT DISORDERS. 2011, vol. 26, No 8, p. 1545-1548. ISSN 0885-3185. Available from: https://dx.doi.org/10.1002/mds.23663.

Basic information

• Original name: The Role of the Inferior Frontal Gyri in Cognitive Processing of Patients with Parkinson's Disease: A Pilot rTMS Study
• Authors: SROVNALOVÁ, Hana (203 Czech Republic, guarantor, belonging to the institution), Radek MAREČEK (203 Czech Republic, belonging to the institution) and Irena REKTOROVÁ (203 Czech Republic, belonging to the institution).
• Edition: MOVEMENT DISORDERS, 2011, 0885-3185.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30000 3. Medical and Health Sciences
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 4.505
• RIV identification code: RIV/00216224:14110/11:00055887
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1002/mds.23663
• UT WoS: 000293334800030
• Keywords in English: Parkinsons disease; repetitive transcranial magnetic stimulation; cognitive; Stroop Test; Frontal Assessment Battery; inferior frontal gyrus
• Tags: International impact

Abstract

We studied whether 1 session of high-frequency repetitive transcranial magnetic stimulation (rTMS) applied sequentially over both the left and right inferior frontal gyri (IFG) would enhance performance in tests evaluating the ability to inhibit habitual responses (Stroop test, ST; Frontal Assessment Battery, FAB) in patients with Parkinson's disease (PD). Methods: Ten nondemented PD patients (6 men, 4 women; age, 66 +/- 6 years; disease duration, 5.4 +/- 2.45 years) entered the randomized, sham stimulation-controlled study with a crossover design. The ST and the FAB were performed prior to and immediately after an appropriate rTMS session. Results: The active but not sham rTMS induced significant improvement in all ST subtests (word, color, color-word). Conversely, the calculated Stroop interference and the FAB scores remained unchanged. Conclusions: In PD patients, rTMS of the IFG increased the speed of cognitive processing in both the congruent and incongruent conditions of the ST.

Links

• MSM0021622404, plan (intention): Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.