J 2011

Mild cognitive impairment exists in Parkinson's disease

REKTOROVÁ, Irena

Basic information

Original name

Mild cognitive impairment exists in Parkinson's disease

Authors

REKTOROVÁ, Irena (203 Czech Republic, guarantor, belonging to the institution)

Edition

Journal of Neural Transmission, 2011, 0300-9564

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

Austria

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.730

RIV identification code

RIV/00216224:14110/11:00055888

Organization unit

Faculty of Medicine

DOI

UT WoS

000293244800008

Keywords in English

Brain imaging; Executive; Memory; Mild cognitive impairment; Parkinsons disease

Tags

International impact
Změněno: 1/3/2012 11:20, Mgr. Michal Petr

Abstract

V originále

Cognitive impairment exists in Parkinsons disease (PD) as a transitional state between cognitively intact and demented PD patients. It seems to be a risk factor for the development of dementia in PD, but the precise criteria and unfavorable cognitive profile of mild cognitive impairment in PD (MCI-PD) have not yet been established. The concept may turn to be different from that in Alzheimers disease since we search for those already diagnosed PD patients who are at risk of developing dementia. In addition, clinical variables specific for PD also play role. Importantly, MCI possesses a metabolic basis in PD. Various biomarkers particularly including neuropsychological testing and the brain imaging hold promise in identification of MCI-PD patients with unfavorable prognoses. Well-designed longitudinal studies in MCI-PD cohorts are needed to assess the sensitivity and specificity of the PD-MCI designation as far as dementia development is concerned.

Links

MSM0021622404, plan (intention)
Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS
Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.