Mild cognitive impairment exists in Parkinson's disease

REKTOROVÁ, Irena. Mild cognitive impairment exists in Parkinson's disease. Journal of Neural Transmission. 2011, vol. 118, No 8, p. 1179-1183. ISSN 0300-9564. Available from: https://dx.doi.org/10.1007/s00702-011-0674-x.

Basic information

• Original name: Mild cognitive impairment exists in Parkinson's disease
• Authors: REKTOROVÁ, Irena (203 Czech Republic, guarantor, belonging to the institution).
• Edition: Journal of Neural Transmission, 2011, 0300-9564.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30000 3. Medical and Health Sciences
• Country of publisher: Austria
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 2.730
• RIV identification code: RIV/00216224:14110/11:00055888
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1007/s00702-011-0674-x
• UT WoS: 000293244800008
• Keywords in English: Brain imaging; Executive; Memory; Mild cognitive impairment; Parkinsons disease
• Tags: International impact

Abstract

Cognitive impairment exists in Parkinsons disease (PD) as a transitional state between cognitively intact and demented PD patients. It seems to be a risk factor for the development of dementia in PD, but the precise criteria and unfavorable cognitive profile of mild cognitive impairment in PD (MCI-PD) have not yet been established. The concept may turn to be different from that in Alzheimers disease since we search for those already diagnosed PD patients who are at risk of developing dementia. In addition, clinical variables specific for PD also play role. Importantly, MCI possesses a metabolic basis in PD. Various biomarkers particularly including neuropsychological testing and the brain imaging hold promise in identification of MCI-PD patients with unfavorable prognoses. Well-designed longitudinal studies in MCI-PD cohorts are needed to assess the sensitivity and specificity of the PD-MCI designation as far as dementia development is concerned.

Links

• MSM0021622404, plan (intention): Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.