| STARŠÍCHOVÁ, Andrea, Lukáš KUBALA, Eva LINCOVÁ, Zuzana PERNICOVÁ, Alois KOZUBÍK a Karel SOUČEK. Dynamic Monitoring of Cellular Remodeling Induced by the Transforming Growth Factor-beta 1. BIOLOGICAL PROCEDURES ONLINE. NEW YORK: SPRINGER, roč. 11, č. 1, s. 316-324. ISSN 1480-9222. doi:10.1007/s12575-009-9017-9. 2009. |
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@article{974977,
author = {Staršíchová, Andrea and Kubala, Lukáš and Lincová, Eva and Pernicová, Zuzana and Kozubík, Alois and Souček, Karel},
article_location = {NEW YORK},
article_number = {1},
doi = {http://dx.doi.org/10.1007/s12575-009-9017-9},
keywords = {real-time cell analysis; cell plasticity; epithelial-mesenchymal transition; transforming growth factor-beta 1; F-actin; cytoskeleton remodeling},
language = {eng},
issn = {1480-9222},
journal = {BIOLOGICAL PROCEDURES ONLINE},
title = {Dynamic Monitoring of Cellular Remodeling Induced by the Transforming Growth Factor-beta 1},
volume = {11},
year = {2009}
}
TY - JOUR
ID - 974977
AU - Staršíchová, Andrea - Kubala, Lukáš - Lincová, Eva - Pernicová, Zuzana - Kozubík, Alois - Souček, Karel
PY - 2009
TI - Dynamic Monitoring of Cellular Remodeling Induced by the Transforming Growth Factor-beta 1
JF - BIOLOGICAL PROCEDURES ONLINE
VL - 11
IS - 1
SP - 316-324
EP - 316-324
PB - SPRINGER
SN - 14809222
KW - real-time cell analysis
KW - cell plasticity
KW - epithelial-mesenchymal transition
KW - transforming growth factor-beta 1
KW - F-actin
KW - cytoskeleton remodeling
N2 - The plasticity of differentiated adult cells could have a great therapeutic potential, but at the same time, it is characteristic of progression of serious pathological states such as cancer and fibrosis. In this study, we report on the application of a real-time noninvasive system for dynamic monitoring of cellular plasticity. Analysis of the cell impedance profile recorded as cell index using a real-time cell analyzer revealed its significant increase after the treatment of prostate epithelial cells with the transforming growth factor-beta 1. Changes in the cell index profile were paralleled with cytoskeleton rebuilding and induction of epithelial-mesenchymal transition and negatively correlated with cell proliferation. This novel application of such approach demonstrated a great potential of the impedance-based system for noninvasive and real-time monitoring of cellular fate.
ER -
STARŠÍCHOVÁ, Andrea, Lukáš KUBALA, Eva LINCOVÁ, Zuzana PERNICOVÁ, Alois KOZUBÍK a Karel SOUČEK. Dynamic Monitoring of Cellular Remodeling Induced by the Transforming Growth Factor-beta 1. \textit{BIOLOGICAL PROCEDURES ONLINE}. NEW YORK: SPRINGER, roč.~11, č.~1, s.~316-324. ISSN~1480-9222. doi:10.1007/s12575-009-9017-9. 2009.
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