SOVADINOVÁ, Iva, Pavel BABICA, Ondřej ADAMOVSKÝ, A. ALPATOVA and B. UPHAM. Epigenetická toxicita komplexních vzorků cyanobakterií - vliv ozonace a chlorace. (Epigenetic toxicity of cyanobacterial extracts: eff ects of ozonation and chlorination). Bulletin VÚRH Vodňany. 2011, vol. 47, No 4, p. 27–35. ISSN 0007-389X.
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Basic information
Original name Epigenetická toxicita komplexních vzorků cyanobakterií - vliv ozonace a chlorace.
Name (in English) Epigenetic toxicity of cyanobacterial extracts: eff ects of ozonation and chlorination
Authors SOVADINOVÁ, Iva (203 Czech Republic, belonging to the institution), Pavel BABICA (203 Czech Republic, guarantor), Ondřej ADAMOVSKÝ (203 Czech Republic, belonging to the institution), A. ALPATOVA (840 United States of America) and B. UPHAM (840 United States of America).
Edition Bulletin VÚRH Vodňany, 2011, 0007-389X.
Other information
Original language Czech
Type of outcome Article in a journal
Field of Study 30304 Public and environmental health
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14310/11:00056095
Organization unit Faculty of Science
Keywords in English cyanobacterial extract; cyanotoxins; inhibition of gap junctional intercellular communication; epigenetic toxicity; ozonation; chlorination
Tags AKR, rivok
Changed by Changed by: prof. RNDr. Luděk Bláha, Ph.D., učo 15473. Changed: 30/3/2012 10:16.
Abstract
Ačkoliv jsou známy nádorově promoční vlastnosti MC-LR a tato látka byla v extraktu sinic detekována, neovlivňoval inhibici/aktivaci GJIC/MAPK v in vitro modelu. Pozorované efekty způsobovala neznámá sloučenina cyanobakteriálního původu. Nádorově promoční aktivita sinicového extraktu byla úplně odstraněna ozonizací, což přináší důležité informace pro hledání účinných strategií pro eliminaci sinicových nádorových promoterů při přípravě pitné vody.
Abstract (in English)
A known tumor promoter, microcystin-LR, was detected in the extract by HPLC-DAD, but this cyanotoxin has been shown not to affect GJIC/MAPK in this in vitro model, thus the effects observed in our study were most likely caused by not-yet-identified chemicals of cyanobacterial origin. Although chemical identity of the responsible agents remains to be elucidated, the information on rapid elimination of the tumor promoting activity and cytotoxicity of cyanobacteria by ozone might have a particular importance for selection of the best technology for drinking water treatment from cyanobacteria-contaminated reservoirs.
Links
ED0001/01/01, research and development projectName: CETOCOEN
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