| ČEJKOVÁ, Darina, Marie ZOBANÍKOVÁ, Lei CHEN, Petra POSPÍŠILOVÁ, Michal STROUHAL, Xiang QIN, Lenka MIKALOVÁ, Stephen J. NORRIS, Donna M. MUZNY, Richard A. GIBBS, Lucinda L. FULTON, Erica SODERGREN, George M. WEINSTOCK and David ŠMAJS. Whole Genome Sequences of Three Treponema pallidum ssp. pertenue Strains: Yaws and Syphilis Treponemes Differ in Less than 0.2% of the Genome Sequence. Online. PLoS Neglected Tropical Diseases. San Francisco: Public Library of Science, 2012, vol. 6, No 1, p. "nestrankovano", 14 pp. ISSN 1935-2727. Available from: https://dx.doi.org/10.1371/journal.pntd.0001471. [citováno 2024-04-23] |
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@article{976503,
author = {Čejková, Darina and Zobaníková, Marie and Chen, Lei and Pospíšilová, Petra and Strouhal, Michal and Qin, Xiang and Mikalová, Lenka and Norris, Stephen J. and Muzny, Donna M. and Gibbs, Richard A. and Fulton, Lucinda L. and Sodergren, Erica and Weinstock, George M. and Šmajs, David},
article_location = {San Francisco},
article_number = {1},
doi = {http://dx.doi.org/10.1371/journal.pntd.0001471},
keywords = {Treponema pallidum; Syphilis; Genome; Yaws},
language = {eng},
issn = {1935-2727},
journal = {PLoS Neglected Tropical Diseases},
title = {Whole Genome Sequences of Three Treponema pallidum ssp. pertenue Strains: Yaws and Syphilis Treponemes Differ in Less than 0.2% of the Genome Sequence},
url = {http://www.plosntds.org/article/info%3Adoi%2F10.1371%2Fjournal.pntd.0001471},
volume = {6},
year = {2012}
}
TY - JOUR
ID - 976503
AU - Čejková, Darina - Zobaníková, Marie - Chen, Lei - Pospíšilová, Petra - Strouhal, Michal - Qin, Xiang - Mikalová, Lenka - Norris, Stephen J. - Muzny, Donna M. - Gibbs, Richard A. - Fulton, Lucinda L. - Sodergren, Erica - Weinstock, George M. - Šmajs, David
PY - 2012
TI - Whole Genome Sequences of Three Treponema pallidum ssp. pertenue Strains: Yaws and Syphilis Treponemes Differ in Less than 0.2% of the Genome Sequence
JF - PLoS Neglected Tropical Diseases
VL - 6
IS - 1
SP - "nestrankovano"
EP - "nestrankovano"
PB - Public Library of Science
SN - 19352727
KW - Treponema pallidum
KW - Syphilis
KW - Genome
KW - Yaws
UR - http://www.plosntds.org/article/info%3Adoi%2F10.1371%2Fjournal.pntd.0001471
L2 - http://www.plosntds.org/article/info%3Adoi%2F10.1371%2Fjournal.pntd.0001471
N2 - Spirochete Treponema pallidum ssp. pertenue (TPE) is the causative agent of yaws while strains of Treponema pallidum ssp. pallidum (TPA) cause syphilis. Both yaws and syphilis are distinguished on the basis of epidemiological characteristics and clinical symptoms. Neither treponeme can reproduce outside the host organism, which precludes the use of standard molecular biology techniques used to study cultivable pathogens. In this study, we determined high quality whole genome sequences of TPE strains and compared them to known genetic information for T. pallidum ssp. pallidum strains. The genome structure was identical in all three TPE strains and also between TPA and TPE strains. The TPE genome length ranged between 1,139,330 bp and 1,139,744 bp. The overall sequence identity between TPA and TPE genomes was 99.8%, indicating that the two pathogens are extremely closely related. A set of 34 TPE genes (3.5%) encoded proteins containing six or more amino acid replacements or other major sequence changes. These genes more often belonged to the group of genes with predicted virulence and unknown functions suggesting their involvement in infection differences between yaws and syphilis.
ER -
ČEJKOVÁ, Darina, Marie ZOBANÍKOVÁ, Lei CHEN, Petra POSPÍŠILOVÁ, Michal STROUHAL, Xiang QIN, Lenka MIKALOVÁ, Stephen J. NORRIS, Donna M. MUZNY, Richard A. GIBBS, Lucinda L. FULTON, Erica SODERGREN, George M. WEINSTOCK and David ŠMAJS. Whole Genome Sequences of Three Treponema pallidum ssp. pertenue Strains: Yaws and Syphilis Treponemes Differ in Less than 0.2\%{} of the Genome Sequence. Online. \textit{PLoS Neglected Tropical Diseases}. San Francisco: Public Library of Science, 2012, vol.~6, No~1, p.~''nestrankovano'', 14 pp. ISSN~1935-2727. Available from: https://dx.doi.org/10.1371/journal.pntd.0001471. [citováno 2024-04-23]
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