Study of Metallothionein Role in Spinocellular Carcinoma
Tissues of Head and Neck Tumours using Brdicka Reaction

J 2012

Study of Metallothionein Role in Spinocellular Carcinoma Tissues of Head and Neck Tumours using Brdicka Reaction

SOCHOR, Jiří, David HYNEK, Ludmila KREJCOVA, Ivo FABRIK, Sona KRIZKOVA et. al.

Basic information

Original name

Study of Metallothionein Role in Spinocellular Carcinoma Tissues of Head and Neck Tumours using Brdicka Reaction

Authors

SOCHOR, Jiří (203 Czech Republic, guarantor), David HYNEK (203 Czech Republic), Ludmila KREJCOVA (203 Czech Republic), Ivo FABRIK (203 Czech Republic), Sona KRIZKOVA (203 Czech Republic), Jaromír GUMULEC (203 Czech Republic, belonging to the institution), Vojtěch ADAM (203 Czech Republic), Petr BABULA (203 Czech Republic), Libuše TRNKOVÁ (203 Czech Republic, belonging to the institution), Marie STIBOROVA (203 Czech Republic), Jaromír HUBALEK (203 Czech Republic), Michal MASAŘÍK (203 Czech Republic, belonging to the institution), Hana BINKOVÁ (203 Czech Republic, belonging to the institution), Tomáš ECKSCHLAGER (203 Czech Republic) and René KIZEK (203 Czech Republic)

Edition

International Journal of Electrochemical Science, 2012, 1452-3981

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10405 Electrochemistry

Country of publisher

Serbia

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.729 in 2011

RIV identification code

RIV/00216224:14110/12:00059525

Organization unit

Faculty of Medicine

UT WoS

000302730300032

Keywords in English

electrochemical detection; cancer; voltammetry; catalytic signal; oral cancer; marker; metastases

Abstract

V originále

Malignant tumours of head and neck localisation represent serious health problem. All over the world, there is about 650 000 of patients who fall ill with head and neck carcinoma per year. Treatment of this malignity is based especially on the well-timed surgery intervention and radiotherapy. Therefore, alternative ways of diagnostics, which would replace commonly used biopsy in combination with computed tomography, are intensely searched. Attention is devoted especially to molecules, whose levels are changed in body due to malignant process and malignant disease progression. The main objective of this study consisted in determination of metallothionein (/MT)/ levels in tumour tissues of patients suffering from head and neck tumours using differential pulse voltammetry Brdicka reaction. Fifty-five samples of tumour tissue (45 % laryngeal, 40 % oropharyngeal, 9 % hypopharyngeal and 6 % oral cavity cancer) were included in this study. After describing of differences in differential pulse voltammograms of individual tumour localisations, content of MT were determined in the above mentioned localisations. The highest MT level was determined in the tissues of oral tumours followed by hypopharynx and larynx. The relatively lowest MT level was determined in tumours of oropharynx. MT level related to the size of primary tumour focus oscillates with the increasing tumour size. Notwithstanding this fact, the increasing tendency with tumour disease progression is observable. Similar tendency was determined for MT level related to the metastatic activity of tumours, where MT level increased with tumour spreading into local lymph nodes. Our results supported findings on the possible connection of MT and tumour progression.

Citovat

SOCHOR, Jiří, David HYNEK, Ludmila KREJCOVA, Ivo FABRIK, Sona KRIZKOVA, Jaromír GUMULEC, Vojtěch ADAM, Petr BABULA, Libuše TRNKOVÁ, Marie STIBOROVA, Jaromír HUBALEK, Michal MASAŘÍK, Hana BINKOVÁ, Tomáš ECKSCHLAGER and René KIZEK. Study of Metallothionein Role in Spinocellular Carcinoma Tissues of Head and Neck Tumours using Brdicka Reaction. International Journal of Electrochemical Science. 2012, vol. 7, No 3, p. 2136-2152. ISSN 1452-3981.

@article{976687,
   author = {Sochor, Jiří and Hynek, David and Krejcova, Ludmila and Fabrik, Ivo and Krizkova, Sona and Gumulec, Jaromír and Adam, Vojtěch and Babula, Petr and Trnková, Libuše and Stiborova, Marie and Hubalek, Jaromír and Masařík, Michal and Binková, Hana and Eckschlager, Tomáš and Kizek, René},
   article_number = {3},
   keywords = {electrochemical detection; cancer; voltammetry; catalytic signal; oral cancer; marker; metastases},
   language = {eng},
   issn = {1452-3981},
   journal = {International Journal of Electrochemical Science},
   title = {Study of Metallothionein Role in Spinocellular Carcinoma Tissues of Head and Neck Tumours using Brdicka Reaction},
   volume = {7},
   year = {2012}
}

TY  - JOUR
ID  - 976687
AU  - Sochor, Jiří - Hynek, David - Krejcova, Ludmila - Fabrik, Ivo - Krizkova, Sona - Gumulec, Jaromír - Adam, Vojtěch - Babula, Petr - Trnková, Libuše - Stiborova, Marie - Hubalek, Jaromír - Masařík, Michal - Binková, Hana - Eckschlager, Tomáš - Kizek, René
PY  - 2012
TI  - Study of Metallothionein Role in Spinocellular Carcinoma Tissues of Head and Neck Tumours using Brdicka Reaction
JF  - International Journal of Electrochemical Science
VL  - 7
IS  - 3
SP  - 2136-2152
EP  - 2136-2152
SN  - 14523981
KW  - electrochemical detection
KW  - cancer
KW  - voltammetry
KW  - catalytic signal
KW  - oral cancer
KW  - marker
KW  - metastases
N2  - Malignant tumours of head and neck localisation represent serious health problem. All over the world, there is about 650 000 of patients who fall ill with head and neck carcinoma per year. Treatment of this malignity is based especially on the well-timed surgery intervention and radiotherapy. Therefore, alternative ways of diagnostics, which would replace commonly used biopsy in combination with computed tomography, are intensely searched. Attention is devoted especially to molecules, whose levels are changed in body due to malignant process and malignant disease progression. The main objective of this study consisted in determination of metallothionein (/MT)/ levels in tumour tissues of patients suffering from head and neck tumours using differential pulse voltammetry Brdicka reaction. Fifty-five samples of tumour tissue (45 % laryngeal, 40 % oropharyngeal, 9 % hypopharyngeal and 6 % oral cavity cancer) were included in this study. After describing of differences in differential pulse voltammograms of individual tumour localisations, content of MT were determined in the above mentioned localisations. The highest MT level was determined in the tissues of oral tumours followed by hypopharynx and larynx. The relatively lowest MT level was determined in tumours of oropharynx. MT level related to the size of primary tumour focus oscillates with the increasing tumour size. Notwithstanding this fact, the increasing tendency with tumour disease progression is observable. Similar tendency was determined for MT level related to the metastatic activity of tumours, where MT level increased with tumour spreading into local lymph nodes. Our results supported findings on the possible connection of MT and tumour progression.
ER  -

SOCHOR, Jiří, David HYNEK, Ludmila KREJCOVA, Ivo FABRIK, Sona KRIZKOVA, Jaromír GUMULEC, Vojtěch ADAM, Petr BABULA, Libuše TRNKOVÁ, Marie STIBOROVA, Jaromír HUBALEK, Michal MASAŘÍK, Hana BINKOVÁ, Tomáš ECKSCHLAGER and René KIZEK. Study of Metallothionein Role in Spinocellular Carcinoma Tissues of Head and Neck Tumours using Brdicka Reaction. \textit{International Journal of Electrochemical Science}. 2012, vol.~7, No~3, p.~2136-2152. ISSN~1452-3981.

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