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@article{976687,
author = {Sochor, Jiří and Hynek, David and Krejcova, Ludmila and Fabrik, Ivo and Krizkova, Sona and Gumulec, Jaromír and Adam, Vojtěch and Babula, Petr and Trnková, Libuše and Stiborova, Marie and Hubalek, Jaromír and Masařík, Michal and Binková, Hana and Eckschlager, Tomáš and Kizek, René},
article_number = {3},
keywords = {electrochemical detection; cancer; voltammetry; catalytic signal; oral cancer; marker; metastases},
language = {eng},
issn = {1452-3981},
journal = {International Journal of Electrochemical Science},
title = {Study of Metallothionein Role in Spinocellular Carcinoma Tissues of Head and Neck Tumours using Brdicka Reaction},
volume = {7},
year = {2012}
}
TY - JOUR
ID - 976687
AU - Sochor, Jiří - Hynek, David - Krejcova, Ludmila - Fabrik, Ivo - Krizkova, Sona - Gumulec, Jaromír - Adam, Vojtěch - Babula, Petr - Trnková, Libuše - Stiborova, Marie - Hubalek, Jaromír - Masařík, Michal - Binková, Hana - Eckschlager, Tomáš - Kizek, René
PY - 2012
TI - Study of Metallothionein Role in Spinocellular Carcinoma Tissues of Head and Neck Tumours using Brdicka Reaction
JF - International Journal of Electrochemical Science
VL - 7
IS - 3
SP - 2136-2152
EP - 2136-2152
SN - 14523981
KW - electrochemical detection
KW - cancer
KW - voltammetry
KW - catalytic signal
KW - oral cancer
KW - marker
KW - metastases
N2 - Malignant tumours of head and neck localisation represent serious health problem. All over the world, there is about 650 000 of patients who fall ill with head and neck carcinoma per year. Treatment of this malignity is based especially on the well-timed surgery intervention and radiotherapy. Therefore, alternative ways of diagnostics, which would replace commonly used biopsy in combination with computed tomography, are intensely searched. Attention is devoted especially to molecules, whose levels are changed in body due to malignant process and malignant disease progression. The main objective of this study consisted in determination of metallothionein (/MT)/ levels in tumour tissues of patients suffering from head and neck tumours using differential pulse voltammetry Brdicka reaction. Fifty-five samples of tumour tissue (45 % laryngeal, 40 % oropharyngeal, 9 % hypopharyngeal and 6 % oral cavity cancer) were included in this study. After describing of differences in differential pulse voltammograms of individual tumour localisations, content of MT were determined in the above mentioned localisations. The highest MT level was determined in the tissues of oral tumours followed by hypopharynx and larynx. The relatively lowest MT level was determined in tumours of oropharynx. MT level related to the size of primary tumour focus oscillates with the increasing tumour size. Notwithstanding this fact, the increasing tendency with tumour disease progression is observable. Similar tendency was determined for MT level related to the metastatic activity of tumours, where MT level increased with tumour spreading into local lymph nodes. Our results supported findings on the possible connection of MT and tumour progression.
ER -
SOCHOR, Jiří, David HYNEK, Ludmila KREJCOVA, Ivo FABRIK, Sona KRIZKOVA, Jaromír GUMULEC, Vojtěch ADAM, Petr BABULA, Libuše TRNKOVÁ, Marie STIBOROVA, Jaromír HUBALEK, Michal MASAŘÍK, Hana BINKOVÁ, Tomáš ECKSCHLAGER and René KIZEK. Study of Metallothionein Role in Spinocellular Carcinoma Tissues of Head and Neck Tumours using Brdicka Reaction. \textit{International Journal of Electrochemical Science}. 2012, vol.~7, No~3, p.~2136-2152. ISSN~1452-3981.
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