KNOPFOVÁ, Lucia, Petr BENEŠ, Lucie PEKARČÍKOVÁ, Markéta HERMANOVÁ, Michal MASAŘÍK, Zuzana PERNICOVÁ, Karel SOUČEK and Jan ŠMARDA. c-Myb regulates matrix metalloproteinases 1/9, and cathepsin D: implications for matrix-dependent breast cancer cell invasion and metastasis. Molecular Cancer. BioMed Central Ltd, 2012, vol. 11, MARCH, p. 15-29. ISSN 1476-4598. Available from: https://dx.doi.org/10.1186/1476-4598-11-15. |
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@article{977034, author = {Knopfová, Lucia and Beneš, Petr and Pekarčíková, Lucie and Hermanová, Markéta and Masařík, Michal and Pernicová, Zuzana and Souček, Karel and Šmarda, Jan}, article_number = {MARCH}, doi = {http://dx.doi.org/10.1186/1476-4598-11-15}, keywords = {c-Myb; Metastasis; Breast cancer; Matrix metalloproteinase; Cathepsin D; Extracellular matrix}, language = {eng}, issn = {1476-4598}, journal = {Molecular Cancer}, title = {c-Myb regulates matrix metalloproteinases 1/9, and cathepsin D: implications for matrix-dependent breast cancer cell invasion and metastasis}, volume = {11}, year = {2012} }
TY - JOUR ID - 977034 AU - Knopfová, Lucia - Beneš, Petr - Pekarčíková, Lucie - Hermanová, Markéta - Masařík, Michal - Pernicová, Zuzana - Souček, Karel - Šmarda, Jan PY - 2012 TI - c-Myb regulates matrix metalloproteinases 1/9, and cathepsin D: implications for matrix-dependent breast cancer cell invasion and metastasis JF - Molecular Cancer VL - 11 IS - MARCH SP - 15-29 EP - 15-29 PB - BioMed Central Ltd SN - 14764598 KW - c-Myb KW - Metastasis KW - Breast cancer KW - Matrix metalloproteinase KW - Cathepsin D KW - Extracellular matrix N2 - The aim of this study was to investigate the role of c-Myb in the metastatic spread of breast tumors. We ectopically expressed c-Myb in human MDA-MB-231 and mouse 4T1 mammary cancer cells to find that c-Myb enhanced migration and ability of these cells to invade Matrigel but not the collagen I matrix in vitro. c-Myb strongly increased the expression/activity of cathepsin D and matrix metalloproteinase (MMP) 9 and significantly downregulated MMP1. The gene coding for cathepsin D was found to act as the c-Myb-responsive gene and downstream effector of the migration-promoting function of c-Myb. Finally, we demonstrated that c-Myb delayed the growth of mammary tumors in BALB/c mice and affected the metastatic potential of breast cancer cells in an organ-specific manner. This study identified c-Myb as a matrix-dependent regulator of invasive behavior of breast cancer cells. ER -
KNOPFOVÁ, Lucia, Petr BENEŠ, Lucie PEKARČÍKOVÁ, Markéta HERMANOVÁ, Michal MASAŘÍK, Zuzana PERNICOVÁ, Karel SOUČEK and Jan ŠMARDA. c-Myb regulates matrix metalloproteinases 1/9, and cathepsin D: implications for matrix-dependent breast cancer cell invasion and metastasis. \textit{Molecular Cancer}. BioMed Central Ltd, 2012, vol.~11, MARCH, p.~15-29. ISSN~1476-4598. Available from: https://dx.doi.org/10.1186/1476-4598-11-15.
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