Clinical correlations of miR-21 expression in colorectal cancer
patients and effects of its inhibition on DLD1 colon cancer
cells

J 2012

Clinical correlations of miR-21 expression in colorectal cancer patients and effects of its inhibition on DLD1 colon cancer cells

FALTEJSKOVÁ, Petra, Andrej BEŠŠE, Sabina ŠEVČÍKOVÁ, Lenka KUBICZKOVÁ, Marek SVOBODA et. al.

Basic information

Original name

Clinical correlations of miR-21 expression in colorectal cancer patients and effects of its inhibition on DLD1 colon cancer cells

Authors

FALTEJSKOVÁ, Petra (203 Czech Republic, belonging to the institution), Andrej BEŠŠE (703 Slovakia), Sabina ŠEVČÍKOVÁ (203 Czech Republic, belonging to the institution), Lenka KUBICZKOVÁ (203 Czech Republic, belonging to the institution), Marek SVOBODA (203 Czech Republic), Jan ŠMARDA (203 Czech Republic, belonging to the institution), Igor KISS (203 Czech Republic), Rostislav VYZULA (203 Czech Republic) and Ondřej SLABÝ (203 Czech Republic, guarantor, belonging to the institution)

Edition

International Journal of Colorectal Disease, New York, Springer, 2012, 0179-1958

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.238

RIV identification code

RIV/00216224:14740/12:00057342

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1007/s00384-012-1461-3

UT WoS

000310088000002

Keywords (in Czech)

miR-21; kolorektální karcinom; DLD-1; 5-FU; L-OHP; senzitivita; apoptóza; migrace

Keywords in English

miR-21; colorectal cancer; DLD-1; 5-FU; SN38; L-OHP; sensitivity; apoptosis; migration

Abstract

V originále

MicroRNA-21 (miR-21) is one of the miRNAs that are frequently and highly overexpressed in tumor tissue of colorectal cancer patients. We confirmed over-expression of miR-21 in colorectal cancer patients and its correlation with advanced disease and shorter overall survival. Our results suggest that it is increased migration activity of colon cancer cells over-expressing miR-21 that can be responsible for these effects.

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

GA301/09/1115, research and development project

Name: Úloha proteinů c-Myb a Cox-2 při tvorbě střevních nádorů

Investor: Czech Science Foundation, The role of c-Myb and Cox-2 proteins in colon carcinogenesis

Citovat

FALTEJSKOVÁ, Petra, Andrej BEŠŠE, Sabina ŠEVČÍKOVÁ, Lenka KUBICZKOVÁ, Marek SVOBODA, Jan ŠMARDA, Igor KISS, Rostislav VYZULA and Ondřej SLABÝ. Clinical correlations of miR-21 expression in colorectal cancer patients and effects of its inhibition on DLD1 colon cancer cells. International Journal of Colorectal Disease. New York: Springer, 2012, vol. 27, No 11, p. 1401-1408. ISSN 0179-1958. Available from: https://dx.doi.org/10.1007/s00384-012-1461-3.

@article{979090,
   author = {Faltejsková, Petra and Bešše, Andrej and Ševčíková, Sabina and Kubiczková, Lenka and Svoboda, Marek and Šmarda, Jan and Kiss, Igor and Vyzula, Rostislav and Slabý, Ondřej},
   article_location = {New York},
   article_number = {11},
   doi = {http://dx.doi.org/10.1007/s00384-012-1461-3},
   keywords = {miR-21; colorectal cancer; DLD-1; 5-FU; SN38; L-OHP; sensitivity; apoptosis; migration},
   language = {eng},
   issn = {0179-1958},
   journal = {International Journal of Colorectal Disease},
   title = {Clinical correlations of miR-21 expression in colorectal cancer patients and effects of its inhibition on DLD1 colon cancer cells},
   url = {http://link.springer.com/article/10.1007%2Fs00384-012-1461-3},
   volume = {27},
   year = {2012}
}

TY  - JOUR
ID  - 979090
AU  - Faltejsková, Petra - Bešše, Andrej - Ševčíková, Sabina - Kubiczková, Lenka - Svoboda, Marek - Šmarda, Jan - Kiss, Igor - Vyzula, Rostislav - Slabý, Ondřej
PY  - 2012
TI  - Clinical correlations of miR-21 expression in colorectal cancer patients and effects of its inhibition on DLD1 colon cancer cells
JF  - International Journal of Colorectal Disease
VL  - 27
IS  - 11
SP  - 1401-1408
EP  - 1401-1408
PB  - Springer
SN  - 01791958
KW  - miR-21
KW  - colorectal cancer
KW  - DLD-1
KW  - 5-FU
KW  - SN38
KW  - L-OHP
KW  - sensitivity
KW  - apoptosis
KW  - migration
UR  - http://link.springer.com/article/10.1007%2Fs00384-012-1461-3
L2  - http://link.springer.com/article/10.1007%2Fs00384-012-1461-3
N2  - MicroRNA-21 (miR-21) is one of the miRNAs that are frequently and highly overexpressed in tumor tissue of colorectal cancer patients. We confirmed over-expression of miR-21 in colorectal cancer patients and its correlation with advanced disease and shorter overall survival. Our results suggest that it is increased migration activity of colon cancer cells over-expressing miR-21 that can be responsible for these effects.
ER  -

FALTEJSKOVÁ, Petra, Andrej BEŠŠE, Sabina ŠEVČÍKOVÁ, Lenka KUBICZKOVÁ, Marek SVOBODA, Jan ŠMARDA, Igor KISS, Rostislav VYZULA and Ondřej SLABÝ. Clinical correlations of miR-21 expression in colorectal cancer patients and effects of its inhibition on DLD1 colon cancer cells. \textit{International Journal of Colorectal Disease}. New York: Springer, 2012, vol.~27, No~11, p.~1401-1408. ISSN~0179-1958. Available from: https://dx.doi.org/10.1007/s00384-012-1461-3.

Detailed Information on Publication Record