Identification and functional screening of microRNAs highly
deregulated in colorectal cancer

J 2012

Identification and functional screening of microRNAs highly deregulated in colorectal cancer

FALTEJSKOVÁ, Petra; Marek SVOBODA; Klára ŠRŮTOVÁ; Jitka MLČOCHOVÁ; Andrej BEŠŠE et al.

Základní údaje

Originální název

Identification and functional screening of microRNAs highly deregulated in colorectal cancer

Název česky

Identifikace a funkční screening miRNA vysoce deregulovaných u CRC

Autoři

Vydání

Journal of Cellular and Molecular Medicine, Malden, USA, WILEY-BLACKWELL, 2012, 1582-1838

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL, URL

Impakt faktor

Impact factor: 4.753

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14740/12:00059697

Organizační jednotka

Středoevropský technologický institut

DOI

https://doi.org/10.1111/j.1582-4934.2012.01579.x

UT WoS

000310555200010

Klíčová slova česky

apoptóza; kolorektální karcinom; expresní profilování; mikroRNA; migrace

Klíčová slova anglicky

apoptosis; colorectal cancer; expression profilin; microRNA; migration

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 21. 11. 2013 10:26, Olga Křížová

Anotace

V originále

The aim of this study was to determine an expression profile of 667 miRNAs in CRC patients and paired non-tumoral tissues. We have identified 42 differentially expressed miRNAs and we have chosen 5 of them for further validation on an independent cohort of 125 CRC patients and in vitro analyses. Our results indicate that miR-378, miR-375, miR-422a and miR-215 play an important role in CRC as tumor suppressors, whereas miR-135b functions as an oncogene and all these miRNAs significantly contribute to the CRC pathogenesis.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

Citovat

FALTEJSKOVÁ, Petra; Marek SVOBODA; Klára ŠRŮTOVÁ; Jitka MLČOCHOVÁ; Andrej BEŠŠE; Jana NEKVINDOVÁ; Lenka RADOVÁ; Pavel FABIAN; Kateřina SLABÁ; Igor KISS; Rostislav VYZULA a Ondřej SLABÝ. Identification and functional screening of microRNAs highly deregulated in colorectal cancer. Journal of Cellular and Molecular Medicine. Malden, USA: WILEY-BLACKWELL, 2012, roč. 16, č. 11, s. 2655-2666. ISSN 1582-1838. Dostupné z: https://doi.org/10.1111/j.1582-4934.2012.01579.x.

@article{979332,
   author = {Faltejsková, Petra and Svoboda, Marek and Šrůtová, Klára and Mlčochová, Jitka and Bešše, Andrej and Nekvindová, Jana and Radová, Lenka and Fabian, Pavel and Slabá, Kateřina and Kiss, Igor and Vyzula, Rostislav and Slabý, Ondřej},
   article_location = {Malden, USA},
   article_number = {11},
   doi = {https://doi.org/10.1111/j.1582-4934.2012.01579.x},
   keywords = {apoptosis; colorectal cancer; expression profilin; microRNA; migration},
   language = {eng},
   issn = {1582-1838},
   journal = {Journal of Cellular and Molecular Medicine},
   title = {Identification and functional screening of microRNAs highly deregulated in colorectal cancer},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/22469014},
   volume = {16},
   year = {2012}
}

TY  - JOUR
ID  - 979332
AU  - Faltejsková, Petra - Svoboda, Marek - Šrůtová, Klára - Mlčochová, Jitka - Bešše, Andrej - Nekvindová, Jana - Radová, Lenka - Fabian, Pavel - Slabá, Kateřina - Kiss, Igor - Vyzula, Rostislav - Slabý, Ondřej
PY  - 2012
TI  - Identification and functional screening of microRNAs highly deregulated in colorectal cancer
JF  - Journal of Cellular and Molecular Medicine
VL  - 16
IS  - 11
SP  - 2655-2666
EP  - 2655-2666
PB  - WILEY-BLACKWELL
SN  - 15821838
KW  - apoptosis
KW  - colorectal cancer
KW  - expression profilin
KW  - microRNA
KW  - migration
UR  - http://www.ncbi.nlm.nih.gov/pubmed/22469014
L2  - http://onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2012.01579.x/pdf
N2  - The aim of this study was to determine an expression profile of 667 miRNAs in CRC patients and paired non-tumoral tissues. We have identified 42 differentially expressed miRNAs and we have chosen 5 of them for further validation on an independent cohort of 125 CRC patients and in vitro analyses. Our results indicate that miR-378, miR-375, miR-422a and miR-215 play an important role in CRC as tumor suppressors, whereas miR-135b functions as an oncogene and all these miRNAs significantly contribute to the CRC pathogenesis.
ER  -

FALTEJSKOVÁ, Petra; Marek SVOBODA; Klára ŠRŮTOVÁ; Jitka MLČOCHOVÁ; Andrej BEŠŠE; Jana NEKVINDOVÁ; Lenka RADOVÁ; Pavel FABIAN; Kateřina SLABÁ; Igor KISS; Rostislav VYZULA a Ondřej SLABÝ. Identification and functional screening of microRNAs highly deregulated in colorectal cancer. \textit{Journal of Cellular and Molecular Medicine}. Malden, USA: WILEY-BLACKWELL, 2012, roč.~16, č.~11, s.~2655-2666. ISSN~1582-1838. Dostupné z: https://doi.org/10.1111/j.1582-4934.2012.01579.x.

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