BIENERTOVÁ VAŠKŮ, Julie, Petr BIENERT, Martin FOREJT, Josef TOMANDL, Zuzana DERFLEROVÁ BRÁZDOVÁ a Anna VAŠKŮ. Genotype X nutrient association of common polymorphisms in obesity-related genes with food preferences and time structure of energy intake. BRITISH JOURNAL OF NUTRITION. 2010, roč. 103, č. 3, s. 352-359. ISSN 0007-1145. doi:10.1017/S0007114509991887.
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Základní údaje
Originální název Genotype X nutrient association of common polymorphisms in obesity-related genes with food preferences and time structure of energy intake
Autoři BIENERTOVÁ VAŠKŮ, Julie (203 Česká republika, garant, domácí), Petr BIENERT (203 Česká republika, domácí), Martin FOREJT (203 Česká republika, domácí), Josef TOMANDL (203 Česká republika, domácí), Zuzana DERFLEROVÁ BRÁZDOVÁ (203 Česká republika, domácí) a Anna VAŠKŮ (203 Česká republika, domácí).
Vydání BRITISH JOURNAL OF NUTRITION, 2010, 0007-1145.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 30202 Endocrinology and metabolism
Stát vydavatele Velká Británie
Utajení není předmětem státního či obchodního tajemství
Impakt faktor Impact factor: 3.072
Kód RIV RIV/00216224:14110/10:00056890
Organizační jednotka Lékařská fakulta
Doi http://dx.doi.org/10.1017/S0007114509991887
UT WoS 000274689400008
Klíčová slova anglicky Adipokines; Polymorphisms; Obesity; Nutrition; Feeding behaviour
Příznaky Mezinárodní význam
Změnil Změnil: doc. RNDr. Josef Tomandl, Ph.D., učo 47. Změněno: 6. 6. 2012 08:55.
Anotace
Personal food preferences can either enhance or Suppress the development of obesity and the selection and proportion of macronutrients in the diet seem to have a heritable component. In the present study, we therefore focused on dietary composition as a specific trait related to obesity and we determined whether genetic variations in leptin (LEP), LEP receptor (LEPR), adiponectin (ADIPOQ), IL-6 and pro-opiomelanocortin (POMC) underlie specific native food preferences and obesity-related anthropometric parameters. The total of 409 individuals of Czech Caucasian origin were enrolled into the present study and 7 d food records were obtained from the study subjects along with selected anthropometric measurements. In a subset of study subjects, plasma levels of ADIPOQ, LEP and soluble LEPR were measured. Independently of the BMI of the individuals, common variations in LEP and LEPR genes were associated with specific eating patterns, mainly with respect to timing of eating. The LEP + 19A/G polymorphism served as an independent predictor for BMI, percentage of body fat and skinfold thickness and significantly affected the time structure of the daily energy intake. The POMC RsaI polymorphism was associated with percentage of body fat. The ADIPOQ 45 T/G polymorphism was associated with the thickness of the subscapular skinfold. The LEPR Gln223Arg polymorphism was associated with multiple parameters, including diastolic blood pressure, meal sizes during the day and plasma ADIPOQ levels. In a separate analysis, soluble leptin receptor (sObR) plasma levels and LEP:sObR ratio were significantly correlated with systolic blood pressure (beta = -0-66, P=0.002; beta = -1.23, P=0.02) and sObR plasma levels also served as an independent predictor for diastolic blood pressure (beta = - 0.50; P=0-04). To conclude, we report common allelic variants associated with specific feeding behaviour and obesity-related anthropometric traits. Moreover, we identified allelic variants that significantly influence the time structure of food intake during the day.
VytisknoutZobrazeno: 7. 12. 2021 22:36