Genomic analysis of resistance/susceptibility to melanoma in
Old Kladruber greying horses

J 2012

Genomic analysis of resistance/susceptibility to melanoma in Old Kladruber greying horses

FUTAS, J., L. VYCHODILOVA, B. HOFMANOVA, M. VRANOVA, L. PUTNOVA et. al.

Basic information

Original name

Genomic analysis of resistance/susceptibility to melanoma in Old Kladruber greying horses

Authors

FUTAS, J. (203 Czech Republic, guarantor), L. VYCHODILOVA (203 Czech Republic), B. HOFMANOVA (203 Czech Republic), M. VRANOVA (203 Czech Republic), L. PUTNOVA (203 Czech Republic), Jan MUŽÍK (203 Czech Republic, belonging to the institution), M. VYSKOCIL (203 Czech Republic), I. VRTKOVA (203 Czech Republic), Ladislav DUŠEK (203 Czech Republic, belonging to the institution), I. MAJZLIK (203 Czech Republic) and P. HORIN (203 Czech Republic)

Edition

Tissue Antigens, 2012, 0001-2815

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

Genetics and molecular biology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.753

RIV identification code

RIV/00216224:14110/12:00059784

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1111/j.1399-0039.2011.01827.x

UT WoS

000300978800003

Keywords in English

association analysis; greying horse; melanoma; microsatellites; single nucleotide polymorphisms

Abstract

V originále

Melanoma is a common disease occurring in many horse breeds. As in all tumors its nature is complex, and specific genes were shown to be involved in the mechanisms of disease in humans as well as in various animal species (1). Grey horses, regardless of the breed, show high incidence of dermal melanomas. A mutation within the syntaxin 17 gene responsible for greying in horses was shown to be associated with occurrence of melanoma in grey horses but the association observed did not explain completely the variation observed (2). Other factors influencing the formation of melanoma thus must be involved. In this context, immunity-related genes can be considered as functional candidate genes. Old Kladruber grey horses were selected as a model for analyzing associations between microsatellite and candidate gene polymorphic markers and the presence of melanoma. Genetic diversity of this old, small, isolated and partially inbred population was characterized previously.

Citovat

FUTAS, J., L. VYCHODILOVA, B. HOFMANOVA, M. VRANOVA, L. PUTNOVA, Jan MUŽÍK, M. VYSKOCIL, I. VRTKOVA, Ladislav DUŠEK, I. MAJZLIK and P. HORIN. Genomic analysis of resistance/susceptibility to melanoma in Old Kladruber greying horses. Tissue Antigens. 2012, vol. 79, No 4, p. 247-248. ISSN 0001-2815. Available from: https://dx.doi.org/10.1111/j.1399-0039.2011.01827.x.

@article{980519,
   author = {Futas, J. and Vychodilova, L. and Hofmanova, B. and Vranova, M. and Putnova, L. and Mužík, Jan and Vyskocil, M. and Vrtkova, I. and Dušek, Ladislav and Majzlik, I. and Horin, P.},
   article_number = {4},
   doi = {http://dx.doi.org/10.1111/j.1399-0039.2011.01827.x},
   keywords = {association analysis; greying horse; melanoma; microsatellites; single nucleotide polymorphisms},
   language = {eng},
   issn = {0001-2815},
   journal = {Tissue Antigens},
   title = {Genomic analysis of resistance/susceptibility to melanoma in Old Kladruber greying horses},
   volume = {79},
   year = {2012}
}

TY  - JOUR
ID  - 980519
AU  - Futas, J. - Vychodilova, L. - Hofmanova, B. - Vranova, M. - Putnova, L. - Mužík, Jan - Vyskocil, M. - Vrtkova, I. - Dušek, Ladislav - Majzlik, I. - Horin, P.
PY  - 2012
TI  - Genomic analysis of resistance/susceptibility to melanoma in Old Kladruber greying horses
JF  - Tissue Antigens
VL  - 79
IS  - 4
SP  - 247-248
EP  - 247-248
SN  - 00012815
KW  - association analysis
KW  - greying horse
KW  - melanoma
KW  - microsatellites
KW  - single nucleotide polymorphisms
N2  - Melanoma is a common disease occurring in many horse breeds. As in all tumors its nature is complex, and specific genes were shown to be involved in the mechanisms of disease in humans as well as in various animal species (1). Grey horses, regardless of the breed, show high incidence of dermal melanomas. A mutation within the syntaxin 17 gene responsible for greying in horses was shown to be associated with occurrence of melanoma in grey horses but the association observed did not explain completely the variation observed (2). Other factors influencing the formation of melanoma thus must be involved. In this context, immunity-related genes can be considered as functional candidate genes. Old Kladruber grey horses were selected as a model for analyzing associations between microsatellite and candidate gene polymorphic markers and the presence of melanoma. Genetic diversity of this old, small, isolated and partially inbred population was characterized previously.
ER  -

FUTAS, J., L. VYCHODILOVA, B. HOFMANOVA, M. VRANOVA, L. PUTNOVA, Jan MUŽÍK, M. VYSKOCIL, I. VRTKOVA, Ladislav DUŠEK, I. MAJZLIK and P. HORIN. Genomic analysis of resistance/susceptibility to melanoma in Old Kladruber greying horses. \textit{Tissue Antigens}. 2012, vol.~79, No~4, p.~247-248. ISSN~0001-2815. Available from: https://dx.doi.org/10.1111/j.1399-0039.2011.01827.x.

Detailed Information on Publication Record