| SZTURZ, Petr, Zdeněk ŘEHÁK, Renata KOUKALOVÁ, Zdeněk ADAM, Marta KREJČÍ, Luděk POUR, Lenka ZAHRADOVÁ, Jiří VANÍČEK, Tomáš NEBESKÝ, Roman HÁJEK and Jiří MAYER. Measuring diffuse metabolic activity on FDG-PET/CT: new method for evaluating Langerhans cell histiocytosis activity in pulmonary parenchyma. Nuclear Medicine and Biology. 2012, vol. 39, No 3, p. 429-436. ISSN 0969-8051. Available from: https://dx.doi.org/10.1016/j.nucmedbio.2011.10.002. |
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@article{980946,
author = {Szturz, Petr and Řehák, Zdeněk and Koukalová, Renata and Adam, Zdeněk and Krejčí, Marta and Pour, Luděk and Zahradová, Lenka and Vaníček, Jiří and Nebeský, Tomáš and Hájek, Roman and Mayer, Jiří},
article_number = {3},
doi = {http://dx.doi.org/10.1016/j.nucmedbio.2011.10.002},
keywords = {Langerhans cell histiocytosis; Interstitial lung disease; Positron emission tomography; Pulmonary function tests; High-resolution computed tomography (HRCT)},
language = {eng},
issn = {0969-8051},
journal = {Nuclear Medicine and Biology},
title = {Measuring diffuse metabolic activity on FDG-PET/CT: new method for evaluating Langerhans cell histiocytosis activity in pulmonary parenchyma},
volume = {39},
year = {2012}
}
TY - JOUR
ID - 980946
AU - Szturz, Petr - Řehák, Zdeněk - Koukalová, Renata - Adam, Zdeněk - Krejčí, Marta - Pour, Luděk - Zahradová, Lenka - Vaníček, Jiří - Nebeský, Tomáš - Hájek, Roman - Mayer, Jiří
PY - 2012
TI - Measuring diffuse metabolic activity on FDG-PET/CT: new method for evaluating Langerhans cell histiocytosis activity in pulmonary parenchyma
JF - Nuclear Medicine and Biology
VL - 39
IS - 3
SP - 429-436
EP - 429-436
SN - 09698051
KW - Langerhans cell histiocytosis
KW - Interstitial lung disease
KW - Positron emission tomography
KW - Pulmonary function tests
KW - High-resolution computed tomography (HRCT)
N2 - Pulmonary Langerhans cell histiocytosis (PLCH) is a rare cause of interstitial lung disease characterized by formation of nodules in the active phase of the disease that evolve into nonactive cystic lesions later on. To evaluate PLCH activity in patients, we developed a new method for measuring diffuse metabolic activity on fluorine-18-fluorodeoxyglucose positron emission tomography/ computed tomography (FDG-PET/CT) using a lung-to-liver activity ratio. Material and Methods: We retrospectively studied a series of 4 FDG-PET and 23 FDG-PET/CT scans from 7 patients with PLCH and analyzed a sample of 100 randomly chosen FDG-PET/CT studies free from any known lung or hepatic diseases. Maximum standardized uptake value (SUVmax) in a spherical volume (6–8 cm in diameter) in the right lung was put into relation with SUVmax in a spherical volume (9–10 cm in diameter) in the reference liver parenchyma to set up the SUVmaxPULMO/SUVmaxHEPAR index. The index values were compared to the disease course in each patient. Results: In patients with PLCH, a close correlation between the index value and the disease course was found in all seven subjects, where the increasing index values indicated disease activity, while decreasing index values were observed after therapy administration. In the group of 100 healthy control subjects, we found index values lower than 0.3 in 80% and lower than 0.4 in 96%. Conclusion: Measuring SUVmaxPULMO/SUVmaxHEPAR values and their time-trend monitoring represent simple, noninvasive screening tools allowing an early diagnosis and treatment response follow-up assessment in patients with PLCH.
ER -
SZTURZ, Petr, Zdeněk ŘEHÁK, Renata KOUKALOVÁ, Zdeněk ADAM, Marta KREJČÍ, Luděk POUR, Lenka ZAHRADOVÁ, Jiří VANÍČEK, Tomáš NEBESKÝ, Roman HÁJEK and Jiří MAYER. Measuring diffuse metabolic activity on FDG-PET/CT: new method for evaluating Langerhans cell histiocytosis activity in pulmonary parenchyma. \textit{Nuclear Medicine and Biology}. 2012, vol.~39, No~3, p.~429-436. ISSN~0969-8051. Available from: https://dx.doi.org/10.1016/j.nucmedbio.2011.10.002.
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