Determinants of Invasively Measured Aortic Pulse Pressure and
its Relationship with B-type Natriuretic Peptides in Stable
Patients with Preserved Left Ventricular Systolic Function

J 2012

Determinants of Invasively Measured Aortic Pulse Pressure and its Relationship with B-type Natriuretic Peptides in Stable Patients with Preserved Left Ventricular Systolic Function

JARKOVSKÝ, Jiří, Jiří PAŘENICA, Roman MIKLÍK, Monika PÁVKOVÁ GOLDBERGOVÁ, Petr KALA et. al.

Basic information

Original name

Determinants of Invasively Measured Aortic Pulse Pressure and its Relationship with B-type Natriuretic Peptides in Stable Patients with Preserved Left Ventricular Systolic Function

Authors

JARKOVSKÝ, Jiří (203 Czech Republic, guarantor, belonging to the institution), Jiří PAŘENICA (203 Czech Republic, belonging to the institution), Roman MIKLÍK (203 Czech Republic, belonging to the institution), Monika PÁVKOVÁ GOLDBERGOVÁ (203 Czech Republic, belonging to the institution), Petr KALA (203 Czech Republic, belonging to the institution), Lenka MALÁSKOVÁ (203 Czech Republic), Zdeňka ČERMÁKOVÁ (203 Czech Republic), Martin POLOCZEK (203 Czech Republic, belonging to the institution), Miroslav VYTISKA (703 Slovakia), Lenka KUBKOVÁ (203 Czech Republic, belonging to the institution), Kateřina HELÁNOVÁ (203 Czech Republic, belonging to the institution), I. PARENICOVA (203 Czech Republic), Simona LITTNEROVÁ (203 Czech Republic, belonging to the institution), L. DOSTALOVA (203 Czech Republic), P. KUBENA (203 Czech Republic), Anna VAŠKŮ (203 Czech Republic, belonging to the institution) and Jindřich ŠPINAR (203 Czech Republic, belonging to the institution)

Edition

EUROPEAN JOURNAL OF CARDIOVASCULAR MEDICINE, 2012, 2042-4884

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/12:00059819

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.5083/ejcm.20424884.67

Keywords in English

aortic pulse pressure; natriuretic peptides; marker

Změněno: 9/4/2013 13:50, Ing. Mgr. Věra Pospíšilíková

Abstract

V originále

Wide aortic pulse pressure (PP) and levels of natriuretic peptides were repeatedly demonstrated as predictors of cardiovascular morbidity and mortality even in a population without a history of heart disease. The aim of the work was to find determinants of invasively measured aortic pulse pressure and B-type natriuretic peptide (BNP), and a relationship of both markers in stable patients undergoing diagnostic coronary angiography with preserved left ventricle systolic function. Population and methods: A total of 386 stable patients with left ventricle ejection fraction > 50%, without acute myocardial infarction, aortic or mitral valve disease were enrolled. Invasive intra-aortic blood pressure was measured using a fluid-filled catheter in the ascending aorta. Samples of venous blood for analysis of the BNP level were drawn before coronary angiography. Results: We found a positive correlation between aortic systolic blood pressure (SBP) and PP (Pearson’s correlation coefficient = 0.44, p<0.001). Positive relationships were determined among aortic PP and gender, age, BNP, glycaemia, high-density lipoprotein (HDL) cholesterol, hypertension and diabetes mellitus. Negative relationships were found among aortic PP and height, weight and ischemic heart disease, but only gender and age were detected as independent factors in multivariate model. Positive correlation of BNP with age, aortic PP, Left ventricular end diastolic pressure (LVEDP), hypertension, smoking and a negative correlation with creatinine, total cholesterol and ischemic heart disease were shown; only age, creatinine, cholesterol and non- smoker status were independent predictors of BNP value in multivariate model. Conclusion: We found independent determinants of two important predictive markers of cardio-vascular morbidity and mortality – BNP and PP - in group of stable patients.

Links

NS10206, research and development project

Name: Asociace polymorfismů v genech pro metaloproteinázy, jejich inhibitory, ACE a ACE2 s centrálním pulsním tlakem u kardiovaskulárních pacientů

Investor: Ministry of Health of the CR

Citovat

JARKOVSKÝ, Jiří, Jiří PAŘENICA, Roman MIKLÍK, Monika PÁVKOVÁ GOLDBERGOVÁ, Petr KALA, Lenka MALÁSKOVÁ, Zdeňka ČERMÁKOVÁ, Martin POLOCZEK, Miroslav VYTISKA, Lenka KUBKOVÁ, Kateřina HELÁNOVÁ, I. PARENICOVA, Simona LITTNEROVÁ, L. DOSTALOVA, P. KUBENA, Anna VAŠKŮ and Jindřich ŠPINAR. Determinants of Invasively Measured Aortic Pulse Pressure and its Relationship with B-type Natriuretic Peptides in Stable Patients with Preserved Left Ventricular Systolic Function. EUROPEAN JOURNAL OF CARDIOVASCULAR MEDICINE. 2012, vol. 11, No 1, p. 32-40. ISSN 2042-4884. Available from: https://dx.doi.org/10.5083/ejcm.20424884.67.

@article{980955,
   author = {Jarkovský, Jiří and Pařenica, Jiří and Miklík, Roman and Pávková Goldbergová, Monika and Kala, Petr and Malásková, Lenka and Čermáková, Zdeňka and Poloczek, Martin and Vytiska, Miroslav and Kubková, Lenka and Helánová, Kateřina and Parenicova, I. and Littnerová, Simona and Dostalova, L. and Kubena, P. and Vašků, Anna and Špinar, Jindřich},
   article_number = {1},
   doi = {http://dx.doi.org/10.5083/ejcm.20424884.67},
   keywords = {aortic pulse pressure; natriuretic peptides; marker},
   language = {eng},
   issn = {2042-4884},
   journal = {EUROPEAN JOURNAL OF CARDIOVASCULAR MEDICINE},
   title = {Determinants of Invasively Measured Aortic Pulse Pressure and its Relationship with B-type Natriuretic Peptides in Stable Patients with Preserved Left Ventricular Systolic Function},
   volume = {11},
   year = {2012}
}

TY  - JOUR
ID  - 980955
AU  - Jarkovský, Jiří - Pařenica, Jiří - Miklík, Roman - Pávková Goldbergová, Monika - Kala, Petr - Malásková, Lenka - Čermáková, Zdeňka - Poloczek, Martin - Vytiska, Miroslav - Kubková, Lenka - Helánová, Kateřina - Parenicova, I. - Littnerová, Simona - Dostalova, L. - Kubena, P. - Vašků, Anna - Špinar, Jindřich
PY  - 2012
TI  - Determinants of Invasively Measured Aortic Pulse Pressure and its Relationship with B-type Natriuretic Peptides in Stable Patients with Preserved Left Ventricular Systolic Function
JF  - EUROPEAN JOURNAL OF CARDIOVASCULAR MEDICINE
VL  - 11
IS  - 1
SP  - 32-40
EP  - 32-40
SN  - 20424884
KW  - aortic pulse pressure
KW  - natriuretic peptides
KW  - marker
N2  - Wide aortic pulse pressure (PP) and levels of natriuretic peptides were repeatedly demonstrated as predictors of cardiovascular morbidity and mortality even in a population without a history of heart disease. The aim of the work was to find determinants of invasively measured aortic pulse pressure and B-type natriuretic peptide (BNP), and a relationship of both markers in stable patients undergoing diagnostic coronary angiography with preserved left ventricle systolic function. Population and methods: A total of 386 stable patients with left ventricle ejection fraction > 50%, without acute myocardial infarction, aortic or mitral valve disease were enrolled. Invasive intra-aortic blood pressure was measured using a fluid-filled catheter in the ascending aorta. Samples of venous blood for analysis of the BNP level were drawn before coronary angiography. Results: We found a positive correlation between aortic systolic blood pressure (SBP) and PP (Pearson’s correlation coefficient = 0.44, p<0.001). Positive relationships were determined among aortic PP and gender, age, BNP, glycaemia, high-density lipoprotein (HDL) cholesterol, hypertension and diabetes mellitus. Negative relationships were found among aortic PP and height, weight and ischemic heart disease, but only gender and age were detected as independent factors in multivariate model. Positive correlation of BNP with age, aortic PP, Left ventricular end diastolic pressure (LVEDP), hypertension, smoking and a negative correlation with creatinine, total cholesterol and ischemic heart disease were shown; only age, creatinine, cholesterol and non- smoker status were independent predictors of BNP value in multivariate model. Conclusion: We found independent determinants of two important predictive markers of cardio-vascular morbidity and mortality – BNP and PP - in group of stable patients.
ER  -

JARKOVSKÝ, Jiří, Jiří PAŘENICA, Roman MIKLÍK, Monika PÁVKOVÁ GOLDBERGOVÁ, Petr KALA, Lenka MALÁSKOVÁ, Zdeňka ČERMÁKOVÁ, Martin POLOCZEK, Miroslav VYTISKA, Lenka KUBKOVÁ, Kateřina HELÁNOVÁ, I. PARENICOVA, Simona LITTNEROVÁ, L. DOSTALOVA, P. KUBENA, Anna VAŠKŮ and Jindřich ŠPINAR. Determinants of Invasively Measured Aortic Pulse Pressure and its Relationship with B-type Natriuretic Peptides in Stable Patients with Preserved Left Ventricular Systolic Function. \textit{EUROPEAN JOURNAL OF CARDIOVASCULAR MEDICINE}. 2012, vol.~11, No~1, p.~32-40. ISSN~2042-4884. Available from: https://dx.doi.org/10.5083/ejcm.20424884.67.

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