Gender differences in total cholesterol levels in patients with
acute heart failure and its importance for short and long time
prognosis

J 2012

Gender differences in total cholesterol levels in patients with acute heart failure and its importance for short and long time prognosis

ŠPINAROVÁ, Lenka, Jindřich ŠPINAR, Jiří VÍTOVEC, Aleš LINHART, Petr WIDIMSKY et. al.

Basic information

Original name

Gender differences in total cholesterol levels in patients with acute heart failure and its importance for short and long time prognosis

Authors

ŠPINAROVÁ, Lenka (203 Czech Republic, guarantor, belonging to the institution), Jindřich ŠPINAR (203 Czech Republic, belonging to the institution), Jiří VÍTOVEC (203 Czech Republic, belonging to the institution), Aleš LINHART (203 Czech Republic), Petr WIDIMSKY (203 Czech Republic), Marian FEDORCO (203 Czech Republic), Filip MALEK (203 Czech Republic), Čestmír CIHALIK (203 Czech Republic), Roman MIKLÍK (203 Czech Republic, belonging to the institution), Ladislav DUŠEK (203 Czech Republic, belonging to the institution), Klaudia ŽIDOVÁ (703 Slovakia, belonging to the institution), Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution), Simona LITTNEROVÁ (203 Czech Republic, belonging to the institution) and Jiří PAŘENICA (203 Czech Republic, belonging to the institution)

Edition

Biomedical Papers, 2012, 1213-8118

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 0.990

RIV identification code

RIV/00216224:14110/12:00059820

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.5507/bp.2012.015

UT WoS

000302753000004

Keywords in English

acute heart failure; AHEAD; cholesterol; gender; in-hospital mortality; prognosis

Abstract

V originále

The purpose of this study was to evaluate whether there are gender differences in total cholesterol levels in patients with acute heart failure and if there is an association of this parameter with short and long time mortality. Methods. The AHEAD MAIN registry is a database conducted in 7 university hospitals, all with 24 h cath lab service, in 4 cities in the Czech Republic. The database included 4 153 patients hospitalised for acute heart failure in the period 2006–2009. 2 384 patients had a complete record of their total cholesterol levels. 946 females and 1437 males were included in this analysis. According to the admission total cholesterol levels, patients were divided into 5 groups: < 4.50 mmol/l (group A), 4.50–4.99 mmol/l (group B), 5.0–5.49 mmol/l (group C), 5.50–5.99 mmol/l (group D) and > 6.0 mmol/l (group E). The median total cholesterol levels were 4.24 in males and 4.60 in females (P<0.001). There were differences in the distribution of total cholesterol levels between men and women: group A 57.6 vs 45.0%, group B 13.8 vs 16.3%, group C 9.8 vs 12.5%, group D 7.7 vs 11.4%, group E 11.1 vs 14.8% respectively (all P<0.001). The median age of men was 68.7 vs 77.3 years in women (P<0.001). In all total cholesterol categories women were older than men: group A 77.7 vs 69.5 years, group B 78.6 vs 69.1 years, group C 77.3 vs 68.8 years, group D 76.8 vs 64.2 years, group E 75.6 vs 64.4 years (all P<0.001). For the calculation of long term mortality, the cohort was divided into three groups: total cholesterol levels below 4.50 mmol/l, 4.50-5.49 mmol/l and above 5.50 mmol/l. The log rank test was used for the analysis. Results. There were no differences in hospital mortality between male and female in general (9.2 vs 10.8%, P<0.202), or in total cholesterol levels in subgroups. Total cholesterol levels were associated with in-hospital mortality (P<0.002). In the long-term follow up (78 months) patients with total cholesterol levels below 4.5 mmol/l had the worst prognosis (P<0.001). An independent influence of total cholesterol level on mortality and survival was confirmed in the multivariate model as well. Conclusions. Women with acute heart failure had higher total cholesterol levels than men in all ages. There was a higher percentage of women with total cholesterol levels above 6 mmol/l and lower percentage in the group below 4.5 mmol/l than in men. In all, total cholesterol categories women were older than men. Total cholesterol levels are important for in- hospital mortality and long term survival of patients admitted for acute heart failure.

Links

MSM0021622402, plan (intention)

Name: Časná diagnostika a léčba kardiovaskulárních chorob

Investor: Ministry of Education, Youth and Sports of the CR, Early diagnostics and treatment of cardiovascular diseases

NS9880, research and development project

Name: Komplexní managment péče o pacienty as akutním srdečním selháním, jejichstřednědobá prognóza a multivariantní prognostický model

Investor: Ministry of Health of the CR

Citovat

ŠPINAROVÁ, Lenka, Jindřich ŠPINAR, Jiří VÍTOVEC, Aleš LINHART, Petr WIDIMSKY, Marian FEDORCO, Filip MALEK, Čestmír CIHALIK, Roman MIKLÍK, Ladislav DUŠEK, Klaudia ŽIDOVÁ, Jiří JARKOVSKÝ, Simona LITTNEROVÁ and Jiří PAŘENICA. Gender differences in total cholesterol levels in patients with acute heart failure and its importance for short and long time prognosis. Biomedical Papers. 2012, vol. 156, No 1, p. 21–28. ISSN 1213-8118. Available from: https://dx.doi.org/10.5507/bp.2012.015.

@article{980957,
   author = {Špinarová, Lenka and Špinar, Jindřich and Vítovec, Jiří and Linhart, Aleš and Widimsky, Petr and Fedorco, Marian and Malek, Filip and Cihalik, Čestmír and Miklík, Roman and Dušek, Ladislav and Židová, Klaudia and Jarkovský, Jiří and Littnerová, Simona and Pařenica, Jiří},
   article_number = {1},
   doi = {http://dx.doi.org/10.5507/bp.2012.015},
   keywords = {acute heart failure; AHEAD; cholesterol; gender; in-hospital mortality; prognosis},
   language = {eng},
   issn = {1213-8118},
   journal = {Biomedical Papers},
   title = {Gender differences in total cholesterol levels in patients with acute heart failure and its importance for short and long time prognosis},
   volume = {156},
   year = {2012}
}

TY  - JOUR
ID  - 980957
AU  - Špinarová, Lenka - Špinar, Jindřich - Vítovec, Jiří - Linhart, Aleš - Widimsky, Petr - Fedorco, Marian - Malek, Filip - Cihalik, Čestmír - Miklík, Roman - Dušek, Ladislav - Židová, Klaudia - Jarkovský, Jiří - Littnerová, Simona - Pařenica, Jiří
PY  - 2012
TI  - Gender differences in total cholesterol levels in patients with acute heart failure and its importance for short and long time prognosis
JF  - Biomedical Papers
VL  - 156
IS  - 1
SP  - 21–28
EP  - 21–28
SN  - 12138118
KW  - acute heart failure
KW  - AHEAD
KW  - cholesterol
KW  - gender
KW  - in-hospital mortality
KW  - prognosis
N2  - The purpose of this study was to evaluate whether there are gender differences in total cholesterol levels in patients with acute heart failure and if there is an association of this parameter with short and long time mortality. Methods. The AHEAD MAIN registry is a database conducted in 7 university hospitals, all with 24 h cath lab service, in 4 cities in the Czech Republic. The database included 4 153 patients hospitalised for acute heart failure in the period 2006–2009. 2 384 patients had a complete record of their total cholesterol levels. 946 females and 1437 males were included in this analysis. According to the admission total cholesterol levels, patients were divided into 5 groups: < 4.50 mmol/l (group A), 4.50–4.99 mmol/l (group B), 5.0–5.49 mmol/l (group C), 5.50–5.99 mmol/l (group D) and > 6.0 mmol/l (group E). The median total cholesterol levels were 4.24 in males and 4.60 in females (P<0.001). There were differences in the distribution of total cholesterol levels between men and women: group A 57.6 vs 45.0%, group B 13.8 vs 16.3%, group C 9.8 vs 12.5%, group D 7.7 vs 11.4%, group E 11.1 vs 14.8% respectively (all P<0.001). The median age of men was 68.7 vs 77.3 years in women (P<0.001). In all total cholesterol categories women were older than men: group A 77.7 vs 69.5 years, group B 78.6 vs 69.1 years, group C 77.3 vs 68.8 years, group D 76.8 vs 64.2 years, group E 75.6 vs 64.4 years (all P<0.001). For the calculation of long term mortality, the cohort was divided into three groups: total cholesterol levels below 4.50 mmol/l, 4.50-5.49 mmol/l and above 5.50 mmol/l. The log rank test was used for the analysis. Results. There were no differences in hospital mortality between male and female in general (9.2 vs 10.8%, P<0.202), or in total cholesterol levels in subgroups. Total cholesterol levels were associated with in-hospital mortality (P<0.002). In the long-term follow up (78 months) patients with total cholesterol levels below 4.5 mmol/l had the worst prognosis (P<0.001). An independent influence of total cholesterol level on mortality and survival was confirmed in the multivariate model as well. Conclusions. Women with acute heart failure had higher total cholesterol levels than men in all ages. There was a higher percentage of women with total cholesterol levels above 6 mmol/l and lower percentage in the group below 4.5 mmol/l than in men. In all, total cholesterol categories women were older than men. Total cholesterol levels are important for in- hospital mortality and long term survival of patients admitted for acute heart failure.
ER  -

ŠPINAROVÁ, Lenka, Jindřich ŠPINAR, Jiří VÍTOVEC, Aleš LINHART, Petr WIDIMSKY, Marian FEDORCO, Filip MALEK, Čestmír CIHALIK, Roman MIKLÍK, Ladislav DUŠEK, Klaudia ŽIDOVÁ, Jiří JARKOVSKÝ, Simona LITTNEROVÁ and Jiří PAŘENICA. Gender differences in total cholesterol levels in patients with acute heart failure and its importance for short and long time prognosis. \textit{Biomedical Papers}. 2012, vol.~156, No~1, p.~21–28. ISSN~1213-8118. Available from: https://dx.doi.org/10.5507/bp.2012.015.

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