Receptor tyrosine kinases activate canonical WNT/beta catenin
signaling via MAP kinase/LRP6 pathway and direct beta-Catenin
phosphorylation

J 2012

Receptor tyrosine kinases activate canonical WNT/beta catenin signaling via MAP kinase/LRP6 pathway and direct beta-Catenin phosphorylation

KREJČÍ, Pavel, Anie AKLIAN, Markéta KAUCKÁ, Eva ŠEVČÍKOVÁ, Jiřina PROCHÁZKOVÁ et. al.

Basic information

Original name

Receptor tyrosine kinases activate canonical WNT/beta catenin signaling via MAP kinase/LRP6 pathway and direct beta-Catenin phosphorylation

Authors

KREJČÍ, Pavel (203 Czech Republic, guarantor, belonging to the institution), Anie AKLIAN (840 United States of America), Markéta KAUCKÁ (203 Czech Republic, belonging to the institution), Eva ŠEVČÍKOVÁ (703 Slovakia, belonging to the institution), Jiřina PROCHÁZKOVÁ (203 Czech Republic, belonging to the institution), Pavol MIKOLKA (703 Slovakia, belonging to the institution), Lukáš BÁLEK (203 Czech Republic, belonging to the institution), Tereza POSPÍŠILOVÁ (203 Czech Republic, belonging to the institution), Tereza SPOUSTOVÁ (203 Czech Republic, belonging to the institution), Vítězslav BRYJA (840 United States of America, belonging to the institution), Iva VESELÁ (840 United States of America, belonging to the institution), Alois KOZUBÍK (203 Czech Republic, belonging to the institution), MaryAnn WEIS (840 United States of America), W.A. PAZNEKAS (840 United States of America), J.H. WOLF (840 United States of America), J.S. GUTKIND (840 United States of America), W.A. WILCOX (840 United States of America), E. WNAG JABS (840 United States of America), Lisa SALAZAR (840 United States of America) and Jan Kukla MAŠEK (203 Czech Republic)

Edition

Plos One, 2012, 1932-6203

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30105 Physiology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.730

RIV identification code

RIV/00216224:14310/12:00067402

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1371/journal.pone.0035826

UT WoS

000305336000063

Keywords in English

Receptor tyrosin kinase; Wnt/beta catenin; MAPK; LRP6

Abstract

V originále

Receptor tyrosine kinase signaling cooperates with WNT/beta catenin signaling in regulating many biological processes, but the mechanisms of their interaction remain poorly defined. We describe a potent activation of WNT/beta catenin by FGFR2 FGFR3, EGFR and TRKA kinases, which is independent of the PI3K/Akt pathway and it depends on ERK-MAPK mediated phospohrylation of WNT co-receptor LRP6.

Links

MSM0021622430, plan (intention)

Name: Funkční a molekulární charakteristiky nádorových a normálních kmenových buněk - identifikace cílů pro nová terapeutika a terapeutické strategie

Investor: Ministry of Education, Youth and Sports of the CR, Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies

MUNI/A/0975/2009, interní kód MU

Name: Podpora výzkumné činnosti studentů v oblasti fyziologie a imunologie živočichů. (Acronym: VYFIŽ)

Investor: Masaryk University, Category A

Citovat

KREJČÍ, Pavel, Anie AKLIAN, Markéta KAUCKÁ, Eva ŠEVČÍKOVÁ, Jiřina PROCHÁZKOVÁ, Pavol MIKOLKA, Lukáš BÁLEK, Tereza POSPÍŠILOVÁ, Tereza SPOUSTOVÁ, Vítězslav BRYJA, Iva VESELÁ, Alois KOZUBÍK, MaryAnn WEIS, W.A. PAZNEKAS, J.H. WOLF, J.S. GUTKIND, W.A. WILCOX, E. WNAG JABS, Lisa SALAZAR and Jan Kukla MAŠEK. Receptor tyrosine kinases activate canonical WNT/beta catenin signaling via MAP kinase/LRP6 pathway and direct beta-Catenin phosphorylation. Plos One. 2012, vol. 7, No 4, p. 1-14. ISSN 1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0035826.

@article{980981,
   author = {Krejčí, Pavel and Aklian, Anie and Kaucká, Markéta and Ševčíková, Eva and Procházková, Jiřina and Mikolka, Pavol and Bálek, Lukáš and Pospíšilová, Tereza and Spoustová, Tereza and Bryja, Vítězslav and Veselá, Iva and Kozubík, Alois and Weis, MaryAnn and Paznekas, W.A. and Wolf, J.H. and Gutkind, J.S. and Wilcox, W.A. and Wnag Jabs, E. and Salazar, Lisa and Mašek, Jan Kukla},
   article_number = {4},
   doi = {http://dx.doi.org/10.1371/journal.pone.0035826},
   keywords = {Receptor tyrosin kinase; Wnt/beta catenin; MAPK; LRP6},
   language = {eng},
   issn = {1932-6203},
   journal = {Plos One},
   title = {Receptor tyrosine kinases activate canonical WNT/beta catenin signaling via MAP kinase/LRP6 pathway and direct beta-Catenin phosphorylation},
   volume = {7},
   year = {2012}
}

TY  - JOUR
ID  - 980981
AU  - Krejčí, Pavel - Aklian, Anie - Kaucká, Markéta - Ševčíková, Eva - Procházková, Jiřina - Mikolka, Pavol - Bálek, Lukáš - Pospíšilová, Tereza - Spoustová, Tereza - Bryja, Vítězslav - Veselá, Iva - Kozubík, Alois - Weis, MaryAnn - Paznekas, W.A. - Wolf, J.H. - Gutkind, J.S. - Wilcox, W.A. - Wnag Jabs, E. - Salazar, Lisa - Mašek, Jan Kukla
PY  - 2012
TI  - Receptor tyrosine kinases activate canonical WNT/beta catenin signaling via MAP kinase/LRP6 pathway and direct beta-Catenin phosphorylation
JF  - Plos One
VL  - 7
IS  - 4
SP  - 1-14
EP  - 1-14
SN  - 19326203
KW  - Receptor tyrosin kinase
KW  - Wnt/beta catenin
KW  - MAPK
KW  - LRP6
N2  - Receptor tyrosine kinase signaling cooperates with WNT/beta catenin signaling in regulating many biological processes, but the mechanisms of their interaction remain poorly defined. We describe a potent activation of WNT/beta catenin by FGFR2 FGFR3, EGFR and TRKA kinases, which is independent of the PI3K/Akt pathway and it depends on ERK-MAPK mediated phospohrylation of WNT co-receptor LRP6.
ER  -

KREJČÍ, Pavel, Anie AKLIAN, Markéta KAUCKÁ, Eva ŠEVČÍKOVÁ, Jiřina PROCHÁZKOVÁ, Pavol MIKOLKA, Lukáš BÁLEK, Tereza POSPÍŠILOVÁ, Tereza SPOUSTOVÁ, Vítězslav BRYJA, Iva VESELÁ, Alois KOZUBÍK, MaryAnn WEIS, W.A. PAZNEKAS, J.H. WOLF, J.S. GUTKIND, W.A. WILCOX, E. WNAG JABS, Lisa SALAZAR and Jan Kukla MAŠEK. Receptor tyrosine kinases activate canonical WNT/beta catenin signaling via MAP kinase/LRP6 pathway and direct beta-Catenin phosphorylation. \textit{Plos One}. 2012, vol.~7, No~4, p.~1-14. ISSN~1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0035826.

Detailed Information on Publication Record