Receptor tyrosine kinases activate canonical WNT/beta catenin signaling via MAP kinase/LRP6 pathway and direct beta-Catenin phosphorylation

KREJČÍ, Pavel, Anie AKLIAN, Markéta KAUCKÁ, Eva ŠEVČÍKOVÁ, Jiřina PROCHÁZKOVÁ, Pavol MIKOLKA, Lukáš BÁLEK, Tereza POSPÍŠILOVÁ, Tereza SPOUSTOVÁ, Vítězslav BRYJA, Iva VESELÁ, Alois KOZUBÍK, MaryAnn WEIS, W.A. PAZNEKAS, J.H. WOLF, J.S. GUTKIND, W.A. WILCOX, E. WNAG JABS, Lisa SALAZAR and Jan Kukla MAŠEK. Receptor tyrosine kinases activate canonical WNT/beta catenin signaling via MAP kinase/LRP6 pathway and direct beta-Catenin phosphorylation. Plos One. 2012, vol. 7, No 4, p. 1-14. ISSN 1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0035826.

Basic information

• Original name: Receptor tyrosine kinases activate canonical WNT/beta catenin signaling via MAP kinase/LRP6 pathway and direct beta-Catenin phosphorylation
• Authors: KREJČÍ, Pavel (203 Czech Republic, guarantor, belonging to the institution), Anie AKLIAN (840 United States of America), Markéta KAUCKÁ (203 Czech Republic, belonging to the institution), Eva ŠEVČÍKOVÁ (703 Slovakia, belonging to the institution), Jiřina PROCHÁZKOVÁ (203 Czech Republic, belonging to the institution), Pavol MIKOLKA (703 Slovakia, belonging to the institution), Lukáš BÁLEK (203 Czech Republic, belonging to the institution), Tereza POSPÍŠILOVÁ (203 Czech Republic, belonging to the institution), Tereza SPOUSTOVÁ (203 Czech Republic, belonging to the institution), Vítězslav BRYJA (840 United States of America, belonging to the institution), Iva VESELÁ (840 United States of America, belonging to the institution), Alois KOZUBÍK (203 Czech Republic, belonging to the institution), MaryAnn WEIS (840 United States of America), W.A. PAZNEKAS (840 United States of America), J.H. WOLF (840 United States of America), J.S. GUTKIND (840 United States of America), W.A. WILCOX (840 United States of America), E. WNAG JABS (840 United States of America), Lisa SALAZAR (840 United States of America) and Jan Kukla MAŠEK (203 Czech Republic).
• Edition: Plos One, 2012, 1932-6203.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30105 Physiology
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 3.730
• RIV identification code: RIV/00216224:14310/12:00067402
• Organization unit: Faculty of Science
• Doi: http://dx.doi.org/10.1371/journal.pone.0035826
• UT WoS: 000305336000063
• Keywords in English: Receptor tyrosin kinase; Wnt/beta catenin; MAPK; LRP6
• Tags: AKR, rivok
• Tags: International impact, Reviewed

Abstract

Receptor tyrosine kinase signaling cooperates with WNT/beta catenin signaling in regulating many biological processes, but the mechanisms of their interaction remain poorly defined. We describe a potent activation of WNT/beta catenin by FGFR2 FGFR3, EGFR and TRKA kinases, which is independent of the PI3K/Akt pathway and it depends on ERK-MAPK mediated phospohrylation of WNT co-receptor LRP6.

Links

• MSM0021622430, plan (intention): Name: Funkční a molekulární charakteristiky nádorových a normálních kmenových buněk - identifikace cílů pro nová terapeutika a terapeutické strategie

Investor: Ministry of Education, Youth and Sports of the CR, Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies

• MUNI/A/0975/2009, interní kód MU: Name: Podpora výzkumné činnosti studentů v oblasti fyziologie a imunologie živočichů. (Acronym: VYFIŽ)

Investor: Masaryk University, Category A