AMATO, Filippo, Eladia Maria PENA-MENDEZ, Tiziana PIVETTA, Nagender Reddy PANYALA and Josef HAVEL. Supramolecular complexes formation. Possibilities of mass spectrometric studies. In 4th EuCheMS Chemistry Congress. 2012.
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Basic information
Original name Supramolecular complexes formation. Possibilities of mass spectrometric studies
Authors AMATO, Filippo (380 Italy, belonging to the institution), Eladia Maria PENA-MENDEZ (724 Spain), Tiziana PIVETTA (380 Italy), Nagender Reddy PANYALA (356 India, belonging to the institution) and Josef HAVEL (203 Czech Republic, guarantor, belonging to the institution).
Edition 4th EuCheMS Chemistry Congress, 2012.
Other information
Original language English
Type of outcome Presentations at conferences
Field of Study 10406 Analytical chemistry
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
WWW Conference website
RIV identification code RIV/00216224:14310/12:00059907
Organization unit Faculty of Science
Keywords in English mass spectrometry; supramolecular aggregates
Tags International impact, Reviewed
Changed by Changed by: Mgr. Filippo Amato, Ph.D., učo 389626. Changed: 2/2/2014 21:16.
Abstract
In supramolecular complexes the molecules or ions are held together by non-covalent interactions: Host + Guest <=> {Host, Guest}. Usually, compounds like cyclic ethers, cyclodextrines, or other macrocycles might act as hosts while various organic/inorganic cations, anions, neutral molecules etc. are playing the role of guests. The paper deals with the application of mass spectrometry (MS) for fast screening of variour host-guests combinations in order to find out the formation of supramolecular complexes and/or to search for new potential drug carriers or to decrease their toxicity. MS was done using either matrices, laser desorption ionization (LDI) or surface assisted LDI. Mass spectrometric analysis was used because the reactions can also be done directly on the MS target and several combinations can be examined with the minimum amount of often scarce and expensive reagents. Several examples of supramolecular complex formation using different types of macrocycles (cyclodextrins, cucurbit[n]urils, etc.) as hosts, and either drugs like antivirals, cancerostatics or inorganics including nanoparticles as guests, will be given and discussed. The proposed application of mass spectrometry represents fast, efficient and economic way to search for the formation of new supramolecular complexes. The results might find application in medicine.
Links
MSM0021622411, plan (intention)Name: Studium a aplikace plazmochemických reakcí v neizotermickém nízkoteplotním plazmatu a jeho interakcí s povrchem pevných látek
Investor: Ministry of Education, Youth and Sports of the CR, Study and application of plasma chemical reactions in non-isothermic low temperature plasma and its interaction with solid surface
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