|Introduction:In clinical practice we often need to decide a correct method for the treatment of the chest wall following trauma, empyema, or local infection. Various methods are available and their aim is the same – to cure the patient’s defect. There are recommended and tried methods of treatment of these serious and often life-threatening defects. Nowadays treatment may also involve NPWT. Method:In the period between June 2010 and January 2011 we researched 8 patients with chest defect after surgery who were treated using NPWT and compared their results with those of patients treated with traditional methods prior to 2010 e.g. Eloesser window in pleural empyema. We evaluated the length of treatment, wound size, onset of infection, pain and the price of treatment. We assessed wound size using the method of WHAT. Results:The patients’ average age was 65.7 years, in the range of 45 – 73 years. The average wound size 17 x 11.6 cm. Treatment with NWPT averaged 12 days, and changed every 4.5 days. All wounds were culture positive: 3 staphylococcus aureus,1 MRSA, 2 alpha hemolytic streptococcus, the others were polymicrobial. There were no mortalities. All wounds healed without muscle flaps, 3 underwent delayed primary closure, 2 split-thickness skin graft, and three healed by secondary intention. There was no significant complication. Conclusion: The NPWT system is a feasible alternative to conventional wound care with infected wounds. Our results show that NPWT is more benficial to the patient, it involves a shorter period of treatment.