Unveiling the mystery of déja vu: The structural anatomy of
déja vu

J 2012

Unveiling the mystery of déja vu: The structural anatomy of déja vu

BRÁZDIL, Milan, Radek MAREČEK, Tomáš URBÁNEK, Tomáš KAŠPÁREK, Michal MIKL et. al.

Basic information

Original name

Unveiling the mystery of déja vu: The structural anatomy of déja vu

Authors

BRÁZDIL, Milan (203 Czech Republic, guarantor, belonging to the institution), Radek MAREČEK (203 Czech Republic, belonging to the institution), Tomáš URBÁNEK (203 Czech Republic, belonging to the institution), Tomáš KAŠPÁREK (203 Czech Republic, belonging to the institution), Michal MIKL (203 Czech Republic, belonging to the institution), Ivan REKTOR (203 Czech Republic, belonging to the institution) and Adam ZEMAN (203 Czech Republic)

Edition

Cortex, Milano, Elsevier Masson, 2012, 0010-9452

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

Italy

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 6.161

RIV identification code

RIV/00216224:14740/12:00060031

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1016/j.cortex.2012.03.004

UT WoS

000308121900013

Keywords in English

déja vu; source-based morphometry; temporal lobe epilepsy; neuroanatomy; postnatal neurogenesis

Abstract

V originále

Deéja vu (DV) is a widespread, fascinating and mysterious human experience. It occurs both in health and in disease, notably as an aura of temporal lobe epilepsy. This feeling of inappropriate familiarity has attracted interest from psychologists and neuroscientists for over a century, but still there is no widely agreed explanation for the phenomenon of non-pathological DV. Here we investigated differences in brain morphology between healthy subjects with and without DV using a novel multivariate neuroimaging technique, Source-Based Morphometry. The analysis revealed a set of cortical (predominantly mesiotemporal) and subcortical regions in which there was significantly less gray matter in subjects reporting DV. In these regions gray matter volume was inversely correlated with the frequency of DV. Our results demonstrate a structural correlate of DV in healthy individuals for the first time and support a neurological explanation for the phenomenon. We hypothesis that the observed local gray matter decrease in subjects experiencing DV reflects an alteration of hippocampal function and postnatal neurogenesis with resulting changes of volume in remote brain regions.

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

MSM0021622404, plan (intention)

Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.

Citovat

BRÁZDIL, Milan, Radek MAREČEK, Tomáš URBÁNEK, Tomáš KAŠPÁREK, Michal MIKL, Ivan REKTOR and Adam ZEMAN. Unveiling the mystery of déja vu: The structural anatomy of déja vu. Cortex. Milano: Elsevier Masson, 2012, vol. 48, No 9, p. 1240-1243. ISSN 0010-9452. Available from: https://dx.doi.org/10.1016/j.cortex.2012.03.004.

@article{983336,
   author = {Brázdil, Milan and Mareček, Radek and Urbánek, Tomáš and Kašpárek, Tomáš and Mikl, Michal and Rektor, Ivan and Zeman, Adam},
   article_location = {Milano},
   article_number = {9},
   doi = {http://dx.doi.org/10.1016/j.cortex.2012.03.004},
   keywords = {déja vu; source-based morphometry; temporal lobe epilepsy; neuroanatomy; postnatal neurogenesis},
   language = {eng},
   issn = {0010-9452},
   journal = {Cortex},
   title = {Unveiling the mystery of déja vu: The structural anatomy of déja vu},
   url = {http://www.cortexjournal.net/article/S0010-9452%2812%2900088-3/abstract},
   volume = {48},
   year = {2012}
}

TY  - JOUR
ID  - 983336
AU  - Brázdil, Milan - Mareček, Radek - Urbánek, Tomáš - Kašpárek, Tomáš - Mikl, Michal - Rektor, Ivan - Zeman, Adam
PY  - 2012
TI  - Unveiling the mystery of déja vu: The structural anatomy of déja vu
JF  - Cortex
VL  - 48
IS  - 9
SP  - 1240-1243
EP  - 1240-1243
PB  - Elsevier Masson
SN  - 00109452
KW  - déja vu
KW  - source-based morphometry
KW  - temporal lobe epilepsy
KW  - neuroanatomy
KW  - postnatal neurogenesis
UR  - http://www.cortexjournal.net/article/S0010-9452%2812%2900088-3/abstract
L2  - http://www.cortexjournal.net/article/S0010-9452%2812%2900088-3/abstract
N2  - Deéja vu (DV) is a widespread, fascinating and mysterious human experience. It occurs both in health and in disease, notably as an aura of temporal lobe epilepsy. This feeling of inappropriate familiarity has attracted interest from psychologists and neuroscientists for over a century, but still there is no widely agreed explanation for the phenomenon of non-pathological DV. Here we investigated differences in brain morphology between healthy subjects with and without DV using a novel multivariate neuroimaging technique, Source-Based Morphometry. The analysis revealed a set of cortical (predominantly mesiotemporal) and subcortical regions in which there was significantly less gray matter in subjects reporting DV. In these regions gray matter volume was inversely correlated with the frequency of DV. Our results demonstrate a structural correlate of DV in healthy individuals for the first time and support a neurological explanation for the phenomenon. We hypothesis that the observed local gray matter decrease in subjects experiencing DV reflects an alteration of hippocampal function and postnatal neurogenesis with resulting changes of volume in remote brain regions.
ER  -

BRÁZDIL, Milan, Radek MAREČEK, Tomáš URBÁNEK, Tomáš KAŠPÁREK, Michal MIKL, Ivan REKTOR and Adam ZEMAN. Unveiling the mystery of déja vu: The structural anatomy of déja vu. \textit{Cortex}. Milano: Elsevier Masson, 2012, vol.~48, No~9, p.~1240-1243. ISSN~0010-9452. Available from: https://dx.doi.org/10.1016/j.cortex.2012.03.004.

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